ChemicalBook > CAS DataBase List > N-Acetyl-L-thioproline

N-Acetyl-L-thioproline

Product Name
N-Acetyl-L-thioproline
CAS No.
54323-50-1
Chemical Name
N-Acetyl-L-thioproline
Synonyms
AC-L-Thz-OH;(R)-Aminofol;N-Ac-L-Pro-OH;N-Ac-L-Thz-OH;N-ACETYL-THIOPROLINE;N-Acetyl-L-thiaproline;N-Acetyl-L-thioproline;N-Acetyl-L-thioproline USP/EP/BP;3-Acetylthiazolidine-4-carboxylic acid;(R)-3-Acetylthiazolidine-4-carboxylicaci
CBNumber
CB7896439
Molecular Formula
C6H9NO3S
Formula Weight
175.21
MOL File
54323-50-1.mol
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N-Acetyl-L-thioproline Property

Melting point:
143-145℃
Boiling point:
439℃/760mm
Density 
1.46
storage temp. 
2-8°C
solubility 
Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.27±0.20(Predicted)
color 
White
InChI
InChI=1S/C6H9NO3S/c1-4(8)7-3-11-2-5(7)6(9)10/h5H,2-3H2,1H3,(H,9,10)/t5-/m0/s1
InChIKey
WXTBYSIPOKXCPM-YFKPBYRVSA-N
SMILES
S1C[C@@H](C(O)=O)N(C(C)=O)C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
A609645
Product name
(R)-Aminofol
Packaging
250mg
Price
$45
Updated
2021/12/16
TRC
Product number
A609645
Product name
(R)-Aminofol
Packaging
5g
Price
$165
Updated
2021/12/16
Activate Scientific
Product number
AS48637
Product name
(R)-3-Acetylthiazolidine-4-carboxylic acid
Purity
95+% ee
Packaging
1g
Price
$21
Updated
2021/12/16
Ark Pharm
Product number
P000369003
Product name
(R)-3-Acetylthiazolidine-4-carboxylic acid
Purity
95+%
Packaging
5g
Price
$35
Updated
2021/12/16
Activate Scientific
Product number
AS48637
Product name
(R)-3-Acetylthiazolidine-4-carboxylic acid
Purity
95+% ee
Packaging
5G
Price
$47
Updated
2021/12/16
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N-Acetyl-L-thioproline Chemical Properties,Usage,Production

Chemical Properties

off-white to white powder

Uses

A cysteine derivative as potential antitumor agent

Synthesis

33898-90-7

34592-47-7

54323-50-1

GENERAL STEPS: L-thioproline (0.11 mol) and potassium chloride solution (100 mL) were added to the reaction vessel. The stirring speed was controlled at 150 rpm. the reaction mixture was heated to 85°C. A solution of 85% 2-thienylacetonitrile (50 mL) was slowly added dropwise with a controlled drip time of 40 min. The stirring rate was maintained and the reaction was continued for 120 minutes. Upon completion of the reaction, a reduced pressure distillation (2.3 kPa) was performed to separate the solid product. To the resulting solid, 90% p-xylene (80 mL) was added and heated to completely dissolve the solid. Decolorization was performed by adding decolorizing molecular sieves, maintaining the solution temperature at 15°C for 35 min. The solid impurities were removed by filtration and dehydrated using phosphorus pentoxide to give the final white N-acetyl-L-thioproline (1) (17.13 g, 89% yield).

References

[1] Patent: CN105541749, 2016, A. Location in patent: Paragraph 0014; 0015

N-Acetyl-L-thioproline Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Acetyl-L-thioproline Suppliers

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View Lastest Price from N-Acetyl-L-thioproline manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
AC-L-Thz-OH 54323-50-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-15
Hebei Yanxi Chemical Co., Ltd.
Product
N-Acetyl-L-thioproline 54323-50-1
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-10-20
Shandong Deshang Chemical Co., Ltd.
Product
N-Acetyl-L-thioproline 54323-50-1
Price
US $8.90-5.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 tons
Release date
2024-07-12

54323-50-1, N-Acetyl-L-thioprolineRelated Search:

ACETYLTHIOCHOLINE IODIDE Ethyl 2-(Chlorosulfonyl)acetate Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Acetyl chloride Thiazolidine-4-carboxylic acid L-PROLINE-(4-3H(N)) cis-4-Hydroxy-L-proline Acetylacetone 2-Methyl-4-isothiazolin-3-one N-ACETYL-L-TYROSINE ETHYL ESTER N-Acetyl-L-proline Acetyl coenzyme A sodium salt tributyl acetocitrate L(-)-Thiazolidine-4-carboxylic acid N-Acetyl-L-thioproline CARBOXYLIC ACID Acetyl-resveratrol

  • (R)-3-acetylthiazolidine-4-carboxylic acid
  • N-Acetyl-L-thiazolidiNe-4-Carboxylic acid
  • (4R)-3-Acetyl-4α-thiazolidinecarboxylic acid
  • 3-Acetylthiazolidine-4-carboxylic acid
  • N-Acetyl-L-thioproline
  • (R)-Aminofol
  • (R)-3-Acetyl-1,3-thiazolidine-4-carboxylic acid
  • 1-acetyl-3-sulfanylidene-2-pyrrolidinecarboxylic acid
  • N-ACETYL-THIOPROLINE
  • N-Acetyl-L-thiaproline
  • N-Ac-L-Pro-OH
  • N-Ac-L-Thz-OH
  • (R)-3-Acetylthiazolidine-4-carboxylic acid(N-Acetyl-L-Thioproline)
  • AC-L-Thz-OH
  • 4-Thiazolidinecarboxylic acid, 3-acetyl-, (4R)-
  • (R)-3-Acetylthiazolidine-4-carboxylicaci
  • N-Acetyl-L-thioproline USP/EP/BP
  • TIANFU-CHEM 54323-50-1 N-Acetyl-L-thioproline
  • (4R)-3-Acetyl-1,3-thiazolidine-4-carboxylic acid
  • (4R)-3-Acetyl-4-thiazolidinecarboxylic acid
  • 54323-50-1
  • Chiral Reagents
  • Heterocycles
  • Sulfur & Selenium Compounds