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Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester

Product Name
Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
CAS No.
2512228-06-5
Chemical Name
Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
Synonyms
Propargyl-PEG1-C2-CONHS ester;2,5-Dioxopyrrolidin-1-yl 3-(2-(prop-2-yn-1-yloxy)ethoxy)propanoate;Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber
CB79012511
Molecular Formula
C12H15NO6
Formula Weight
269.25
MOL File
2512228-06-5.mol
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Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester Property

Boiling point:
389.8±50.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester Chemical Properties,Usage,Production

Uses

Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Biological Activity

Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014.

Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester Suppliers

China 18 United States 1 Global 19
Xi'an Confluore Biological Technology Co., Ltd.
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Alfa Chemistry
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Shanghai Easy CDMO Co.,Ltd
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CHENGDU YINGNUOLING PHARMACEUTICAL TECHNOLOGY CO.,LTD
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View Lastest Price from Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Propargyl-PEG2-NHS ester 2512228-06-5
Price
US $0.00/g
Min. Order
5g
Purity
>98.00%
Supply Ability
5g
Release date
2024-03-26

2512228-06-5, Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl esterRelated Search:

Propargyl-PEG2-methylamine Propargyl-PEG2-t-butyl ester 3-(2-(2-Azidoethoxy)ethoxy)prop-1-yne 3-(2-Methoxyethoxy)prop-1-yne INDEX NAME NOT YET ASSIGNED INDEX NAME NOT YET ASSIGNED INDEX NAME NOT YET ASSIGNED INDEX NAME NOT YET ASSIGNED INDEX NAME NOT YET ASSIGNED INDEX NAME NOT YET ASSIGNED INDEX NAME NOT YET ASSIGNED INDEX NAME NOT YET ASSIGNED INDEX NAME NOT YET ASSIGNED INDEX NAME NOT YET ASSIGNED INDEX NAME NOT YET ASSIGNED INDEX NAME NOT YET ASSIGNED :4',5'-bis(4-carboxyphenyl)-3',6'-dimethyl-[1,1':2',1''-terphenyl]-4,4''-dicarboxylic acid INDEX NAME NOT YET ASSIGNED

  • 2,5-Dioxopyrrolidin-1-yl 3-(2-(prop-2-yn-1-yloxy)ethoxy)propanoate
  • Propargyl-PEG1-C2-CONHS ester
  • Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
  • 2512228-06-5