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5-Fluoro-3-iodo-1H-indazole

Product Name
5-Fluoro-3-iodo-1H-indazole
CAS No.
858629-06-8
Chemical Name
5-Fluoro-3-iodo-1H-indazole
Synonyms
5-Fluoro-3-iodo-1H-indazole;5-fluoro-3-iodo-2H-indazole;1H-INDAZOLE,5-FLUORO-3-IODO-;5-FLUORO-3-IODO-1H-INDAZOLE 98%;5-fluoro-3-iodo-1H-indazole(SALTDATA: FREE)
CBNumber
CB7970672
Molecular Formula
C7H4FIN2
Formula Weight
262.02
MOL File
858629-06-8.mol
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5-Fluoro-3-iodo-1H-indazole Property

Boiling point:
361.4±22.0 °C(Predicted)
Density 
2.158±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
10.94±0.40(Predicted)
Appearance
Off-white to light yellow Solid
InChI
InChI=1S/C7H4FIN2/c8-4-1-2-6-5(3-4)7(9)11-10-6/h1-3H,(H,10,11)
InChIKey
CZUPBTJBMHZBTJ-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(F)C=C2)C(I)=N1
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B435018
Product name
5-Fluoro-3-iodo-1H-indazole
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
L822
Product name
5-Fluoro-3-iodo-1H-indazole
Packaging
1g
Price
$96
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0013607
Product name
5-FLUORO-3-IODO-1H-INDAZOLE
Purity
95.00%
Packaging
5G
Price
$1672.44
Updated
2021/12/16
Apolloscientific
Product number
PC8399
Product name
5-Fluoro-3-iodo-1H-indazole
Purity
97%
Packaging
1g
Price
$16
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-K-X6
Product name
5-Fluoro-3-iodo-1H-indazole
Purity
97%
Packaging
1g
Price
$32
Updated
2021/12/16
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5-Fluoro-3-iodo-1H-indazole Chemical Properties,Usage,Production

Synthesis

348-26-5

858629-06-8

5-Fluoro-1H-indazole (2.0 g, 14.0 mmol) was used as raw material and dissolved in DIVIF (50 mL). To this solution, iodine (7.46 g, 28.0 mmol) and potassium hydroxide (2.4 g, 42 mmol) were added sequentially at 0 °C. The reaction mixture was stirred at 0 °C for 0.5 h and then gradually warmed up to room temperature. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was filtered and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=3/1) to afford 5-fluoro-3-iodo-1H-indazole (3.7 g, yield: 96.1%) as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ=13.64 (s, 1H), 7.63 (dd, J=4.8,4.4 Hz, 1H), 7.38-7.30 (m, 1H), 7.20 (dd, J=6.4,2.4 Hz, 1H).

References

[1] Patent: WO2018/132372, 2018, A1. Location in patent: Paragraph 01229
[2] Patent: WO2018/188590, 2018, A1. Location in patent: Paragraph 00437
[3] Synthesis, 2011, # 19, p. 3089 - 3098
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 12, p. 5419 - 5434
[5] Molecules, 2018, vol. 23, # 8,

5-Fluoro-3-iodo-1H-indazole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Fluoro-3-iodo-1H-indazole Suppliers

China 71 Germany 2 India 1 United Kingdom 1 United States 12 Global 87
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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001-857-928-2050 or 1-888-588-9418
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+86 10 61256049
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Nanjing Norris-Pharm Technology Co., Ltd
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+86-25-52131256
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China
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Shanghai Devinchem Ltd
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027-65318838 13646286950
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sales@devinchem.com
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China
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Shanghai YuYuan Pharmaceutical Co., Ltd.
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13052276172
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13052276172
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product@yuyuanpharm.com
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China
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View Lastest Price from 5-Fluoro-3-iodo-1H-indazole manufacturers

Career Henan Chemical Co
Product
5-Fluoro-3-iodo-1H-indazole 858629-06-8
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-13

858629-06-8, 5-Fluoro-3-iodo-1H-indazoleRelated Search:

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  • 5-FLUORO-3-IODO-1H-INDAZOLE 98%
  • 5-Fluoro-3-iodo-1H-indazole
  • 5-fluoro-3-iodo-1H-indazole(SALTDATA: FREE)
  • 1H-INDAZOLE,5-FLUORO-3-IODO-
  • 5-fluoro-3-iodo-2H-indazole
  • 858629-06-8