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IRAK-1/4 INHIBITOR I

Product Name
IRAK-1/4 INHIBITOR I
CAS No.
509093-47-4
Chemical Name
IRAK-1/4 INHIBITOR I
Synonyms
CS-1991;IRAK-1/4 Inhibitor;IRAK-1/4 INHIBITOR I;IIRAK-1-4 Inhibitor I;Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor;N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole;1-(2-(4-Morpholinyl)ethyl)-2-(3-nitrobenzoylamino)benzimidazole;N-[1-(2-morpholin-4-ylethyl)benzimidazol-2-yl]-3-nitrobenzamide;InSolution? Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor;3-Nitro-N-(1-(2-morpholin-4-ylethyl)-1H-benzimidazol-2-yl)benzamide
CBNumber
CB7972737
Molecular Formula
C20H21N5O4
Formula Weight
395.41
MOL File
509093-47-4.mol
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IRAK-1/4 INHIBITOR I Property

Density 
1.40
storage temp. 
2-8°C
solubility 
DMSO: ≥5mg/mL
form 
Yellow crystalline solid
pka
11.54±0.43(Predicted)
color 
off-white to light yellow
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-36/37-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
407602
Product name
InSolution? Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor
Packaging
5mg
Price
$172
Updated
2024/03/01
Sigma-Aldrich
Product number
407601
Product name
Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor
Packaging
5mg
Price
$159
Updated
2024/03/01
Cayman Chemical
Product number
17540
Product name
IRAK-1/4 Inhibitor
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17540
Product name
IRAK-1/4 Inhibitor
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Sigma-Aldrich
Product number
I5409
Product name
IRAK-1/4 Inhibitor I
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$193
Updated
2024/03/01
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IRAK-1/4 INHIBITOR I Chemical Properties,Usage,Production

Uses

IRAK-1/4 Inhibitor (interleukin-1 receptor-associated kinases) are important mediators in signal transduction of TIR family members. This regulation protects against the development of cancers and other diseases.

Uses

IRAK-1/4 inhibitor I has been used in various studies to inhibit IRAK1 in hepatoma cell lines and head and neck squamous cell carcinoma (HNSCC) cell lines.

Biological Activity

irak-1-4 inhibitor i is an inhibitor of both irak-1 and irak-4 with ic50 values of 0.3μm and 0.2μm , respectively [1].il-1 receptor-associated kinases play important roles in signal transduction. there are totally four members of the iraks, they are irak-1, irak-2, irak-m and irak-4. irak-4 can activate nf-κb and mapk pathways and it is shown that the inhibition of irak-4 can be an anti-inflammatory therapy. irak-1-4 inhibitor i is an analog of an initial irak-4 inhibitor hit, which is screened out from a small molecule li brary against irak-4. with the less basic n-ethylenemorpholine moiety, irak-1-4 inhibitor i has a higher potency than other analogs. additionally, it does not show any cytotoxicity in a 72 h proliferation assay in hela cells(ed50 >30μm) [1].

Biochem/physiol Actions

IRAK1 overexpression leads to the development of head and neck squamous cell carcinoma (HNSCC). Therefore, IRAK-1/4 inhibitor I might be a potential therapeutic for HNSCC tumors. Various experimental studies states that IRAK-1/4 inhibitor might have a potential to exhibit?inhibitory effects on the nuclear factor (NF)-κB signaling pathway.

storage

Store at -20°C

References

[1] jay p. powers, shyun li, juan c. jaen, jinqian liu, nigel p. c. walker, zhulun wang and holger wesche. discovery and initial sar of inhibitors of interleukin-1 receptor-associated kinase-4. bioorganic & medicinal chemistry letters. 2006, 16: 2842–2845.

IRAK-1/4 INHIBITOR I Preparation Products And Raw materials

Raw materials

Preparation Products

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IRAK-1/4 INHIBITOR I Suppliers

Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from IRAK-1/4 INHIBITOR I manufacturers

Career Henan Chemical Co
Product
IRAK-1/4 INHIBITOR I 509093-47-4
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

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