IRAK-1/4 INHIBITOR I

Product Name: IRAK-1/4 INHIBITOR I
CAS No.: 509093-47-4
Chemical Name: IRAK-1/4 INHIBITOR I
Synonyms: CS-1991;IRAK-1/4 Inhibitor;IRAK-1/4 INHIBITOR I;IIRAK-1-4 Inhibitor I;Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor;N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole;1-(2-(4-Morpholinyl)ethyl)-2-(3-nitrobenzoylamino)benzimidazole;N-[1-(2-morpholin-4-ylethyl)benzimidazol-2-yl]-3-nitrobenzamide;InSolution? Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor;3-Nitro-N-(1-(2-morpholin-4-ylethyl)-1H-benzimidazol-2-yl)benzamide
CBNumber: CB7972737
Molecular Formula: C20H21N5O4
Formula Weight: 395.41
MOL File: 509093-47-4.mol

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IRAK-1/4 INHIBITOR I Property

Density: 1.40
storage temp.: 2-8°C
solubility: DMSO: ≥5mg/mL
form: Yellow crystalline solid
pka: 11.54±0.43(Predicted)
color: off-white to light yellow

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38
Safety Statements: 26-36/37-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 407602
Product name: InSolution? Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Sigma-Aldrich

Product number: 407601
Product name: Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor
Packaging: 5mg
Price: $159
Updated: 2024/03/01

Cayman Chemical

Product number: 17540
Product name: IRAK-1/4 Inhibitor
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17540
Product name: IRAK-1/4 Inhibitor
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Sigma-Aldrich

Product number: I5409
Product name: IRAK-1/4 Inhibitor I
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $193
Updated: 2024/03/01

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IRAK-1/4 INHIBITOR I Chemical Properties,Usage,Production

Uses

IRAK-1/4 Inhibitor (interleukin-1 receptor-associated kinases) are important mediators in signal transduction of TIR family members. This regulation protects against the development of cancers and other diseases.

Uses

IRAK-1/4 inhibitor I has been used in various studies to inhibit IRAK1 in hepatoma cell lines and head and neck squamous cell carcinoma (HNSCC) cell lines.

Biological Activity

irak-1-4 inhibitor i is an inhibitor of both irak-1 and irak-4 with ic50 values of 0.3μm and 0.2μm , respectively [1].il-1 receptor-associated kinases play important roles in signal transduction. there are totally four members of the iraks, they are irak-1, irak-2, irak-m and irak-4. irak-4 can activate nf-κb and mapk pathways and it is shown that the inhibition of irak-4 can be an anti-inflammatory therapy. irak-1-4 inhibitor i is an analog of an initial irak-4 inhibitor hit, which is screened out from a small molecule li brary against irak-4. with the less basic n-ethylenemorpholine moiety, irak-1-4 inhibitor i has a higher potency than other analogs. additionally, it does not show any cytotoxicity in a 72 h proliferation assay in hela cells(ed50 >30μm) [1].

Biochem/physiol Actions

IRAK1 overexpression leads to the development of head and neck squamous cell carcinoma (HNSCC). Therefore, IRAK-1/4 inhibitor I might be a potential therapeutic for HNSCC tumors. Various experimental studies states that IRAK-1/4 inhibitor might have a potential to exhibit?inhibitory effects on the nuclear factor (NF)-κB signaling pathway.

storage

Store at -20°C

References

[1] jay p. powers, shyun li, juan c. jaen, jinqian liu, nigel p. c. walker, zhulun wang and holger wesche. discovery and initial sar of inhibitors of interleukin-1 receptor-associated kinase-4. bioorganic & medicinal chemistry letters. 2006, 16: 2842–2845.

IRAK-1/4 INHIBITOR I Preparation Products And Raw materials

Raw materials

Preparation Products

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IRAK-1/4 INHIBITOR I Suppliers

China 71 India 1 Switzerland 1 United Kingdom 1 United States 16 Global 90

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View Lastest Price from IRAK-1/4 INHIBITOR I manufacturers

Career Henan Chemical Co

Product: IRAK-1/4 INHIBITOR I 509093-47-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

509093-47-4, IRAK-1/4 INHIBITOR IRelated Search:

DEMETON S 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide 4-[[[3-(3,4-Dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]methyl]benzenesulfonamide 4-[6-[[(Furan-2-yl)methyl]amino]imidazo[1,2-b]pyridazin-3-yl]phenol IRAK-1/4 INHIBITOR I 1-(2-DIETHYLAMINO-ETHYL)-1H-BENZOIMIDAZOL-2-YLAMINE

3-Nitro-N-(1-(2-morpholin-4-ylethyl)-1H-benzimidazol-2-yl)benzamide

BenzaMide, N-[1-[2-(4-Morpholinyl)ethyl]-1H-benziMidazol-2-yl]-3-nitro-

Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor

InSolution? Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor

IIRAK-1-4 Inhibitor I

1-(2-(4-Morpholinyl)ethyl)-2-(3-nitrobenzoylamino)benzimidazole

N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole

IRAK-1/4 INHIBITOR I

N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, 1-(2-(4-Morpholinyl)ethyl)-2-(3-nitrobenzoylamino)benzimidazole

IRAK-1/4 Inhibitor

IRAK-1-4 INHIBITOR I ;INTERLEUKIN-1 RECEPTOR-ASSOCIATED-KINASE-1/4 INHIBITOR

N-[1-(2-morpholin-4-ylethyl)benzimidazol-2-yl]-3-nitrobenzamide

InSolution Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem

Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem

N-[1-[2-(4-Morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitrobenzamide

CS-1991

N-(1-(2-morpholinoethyl)-1H-benzo[d]imidazol-2-yl)-3-nitrobenzamide

IRAK,inhibit,Interleukin-1 receptor associated kinase,IRAK 1 4 Inhibitor I,IRAK14 Inhibitor I,IL-1R associated kinase,Inhibitor

509093-47-4

Inhibitors