ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE

Product Name: ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE
CAS No.: 77156-78-6
Chemical Name: ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE
Synonyms: BUTTPARK 20\09-61;ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE;ETHYL 4-HYDROXY-6-METHOXY-3-QUINOLINECARBOXYLATE;ethyl 6-methoxy-4-oxo-1H-quinoline-3-carboxylate;ethyl 6-methoxy-4-hydroxy-3-quinoline-carboxylate;2-ethyl-6-methoxy-4-oxo-1H-quinoline-3-carboxylate;Ethyl 4-hydroxy-6-(methyloxy)-3-quinolinecarboxylate;Ethyl 6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate;Ethyl 1,4-dihydro-6-methoxy-4-oxoquinoline-3-carboxylate;4-Hydroxy-6-methoxy-3-quinolinecarboxylic acid ethyl ester
CBNumber: CB8100742
Molecular Formula: C13H13NO4
Formula Weight: 247.25
MOL File: 77156-78-6.mol

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ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE Property

Melting point:: 280-283℃
Boiling point:: 373.2±37.0 °C(Predicted)
Density: 1.277
storage temp.: Sealed in dry,Room Temperature
pka: 2.72±0.50(Predicted)
Appearance: Light brown to brown Solid
InChI: InChI=1S/C13H13NO4/c1-3-18-13(16)10-7-14-11-5-4-8(17-2)6-9(11)12(10)15/h4-7H,3H2,1-2H3,(H,14,15)
InChIKey: VNGGYIBIGOOVNP-UHFFFAOYSA-N
SMILES: N1C2C(=CC(OC)=CC=2)C(O)=C(C(OCC)=O)C=1

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BBO000179
Product name: 4-Hydroxy-6-methoxyquinoline-3-carboxylic acid ethyl ester
Purity: Aldrich
Packaging: 1g
Price: $134
Updated: 2023/06/20

TRC

Product number: E945470
Product name: Ethyl4-hydroxy-6-methoxyquinoline-3-carboxylate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: E945470
Product name: Ethyl4-hydroxy-6-methoxyquinoline-3-carboxylate
Packaging: 1g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H29-1-2M
Product name: Ethyl 1,4-dihydro-6-methoxy-4-oxoquinoline-3-carboxylate
Packaging: 1g
Price: $192
Updated: 2021/12/16

AK Scientific

Product number: Y3306
Product name: Ethyl4-hydroxy-6-methoxyquinoline-3-carboxylate
Packaging: 5g
Price: $249
Updated: 2021/12/16

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ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

83507-70-4

77156-78-6

A solution was prepared from diethyl 2-[(4-methoxyanilino)methylene]malonate (CAS: 83507-70-4, 71.4 g, 0.24 mol) in 150 mL of diphenyl ether. The reaction system was placed in a metal bath and slowly heated to 243 °C and maintained at this temperature for 3 hours. During the reaction, 15 mL of liquid was distilled. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently dissolved by adding 250 mL of hexane. After stirring the mixture for 3 hours, a filtration operation was performed. The resulting solid was washed with hexane and dried to give ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate (25.0 g, 0.10 mol, 41% yield), the purity of which meets the requirements for direct use in subsequent reactions. The structure of the product was confirmed by 1H-NMR (CDCl3) and LC-MS: 1H-NMR (CDCl3) δ= 1.28 (t, 3H), 3.85 (s, 3H), 4.21 (q, 2H), 7.34 (dd, 1H), 7.55-7.62 (m, 2H), 8.49 (s, 1H); LC-MS: Rt = 1.17 min ; MS: m/z = 248 [M + 1]+.

References

[1] Patent: WO2006/2047, 2006, A2. Location in patent: Page/Page column 60
[2] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 1 - 16
[3] Organic Process Research and Development, 2014, vol. 18, # 11, p. 1482 - 1491
[4] Tetrahedron Letters, 2017, vol. 58, # 8, p. 794 - 796
[5] Journal of the American Chemical Society, 1946, vol. 68, p. 1204,1206

ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE Suppliers

China 60 Germany 1 India 3 Switzerland 2 United Kingdom 8 United States 15 Global 89

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View Lastest Price from ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE 77156-78-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Kg/T
Release date: 2019-12-19

77156-78-6, ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATERelated Search:

4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL 4-HYDROXY-8-METHOXYQUINOLINE-3-CARBOXYLATE 6,7-DIMETHOXY-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER buquinolate 4-HYDROXY-6-METHOXYQUINOLINE 6-Methoxyquinoline ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE Decoquinate Ciproquinate Quincarbate 4-HYDROXY-6-METHOXYQUINOLINE 8-HYDROXY-[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLIC ACID ETHYL ESTER AURORA 17941 ETHYL 4-HYDROXY-6-(TRIFLUOROMETHOXY)QUINOLINE-3-CARBOXYLATE ETHYL 4-HYDROXY-8-METHOXYQUINOLINE-2-CARBOXYLATE 4-OXO-6-TRIFLUOROMETHOXY-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 3-Quinolinecarboxylic acid, 4-hydroxy-6-methoxy-2-phenyl-, ethyl ester AURORA 17731

ETHYL 4-HYDROXY-6-METHOXY-3-QUINOLINECARBOXYLATE

ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE

BUTTPARK 20\09-61

4-HYDROXY-6-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

4-Hydroxy-6-methoxy-3-quinolinecarboxylic acid ethyl ester

4-keto-6-methoxy-1H-quinoline-3-carboxylic acid ethyl ester

ethyl 6-methoxy-4-oxo-1H-quinoline-3-carboxylate

Ethyl 4-hydroxy-6-(methyloxy)-3-quinolinecarboxylate

ethyl 6-methoxy-4-hydroxy-3-quinoline-carboxylate

Ethyl 1,4-dihydro-6-methoxy-4-oxoquinoline-3-carboxylate

Ethyl 6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate

2-ethyl-6-methoxy-4-oxo-1H-quinoline-3-carboxylate

3-Quinolinecarboxylic acid, 4-hydroxy-6-methoxy-, ethyl ester

ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE ISO 9001：2015 REACH

ethyl 4-hydroxy-6-methoxy-quinoline-3-carboxylate - [E87399]

77156-78-6

blocks

Carboxes

Quinolines