ChemicalBook > CAS DataBase List > (R)-(-)-1-Benzyl-3-hydroxypiperidine

(R)-(-)-1-Benzyl-3-hydroxypiperidine

Product Name
(R)-(-)-1-Benzyl-3-hydroxypiperidine
CAS No.
91599-81-4
Chemical Name
(R)-(-)-1-Benzyl-3-hydroxypiperidine
Synonyms
(R)-1-BENZYL-3-PIPERIDINOL;(R)-1-BENZYL-PIPERIDIN-3-OL;(R)-1-Benzyl-3-hydroxypiperidi;)-1-Benzyl-3-hydroxypiperidinol;(R)-1-BENZYL-3-HYDROXYPIPERIDINE;(R)-N-BENZYL-3-HYDROXYPIPERIDINE;(R)-1-(PhenylMethyl)-3-piperidinol;(R)-1-N-BENZYL-3-HYDROXY-PIPERIDINE;(R)-(-)-1-BENZYL-3-HYDROXYPIPERIDINE;(R)-1-Benzyl-3-hydroxypiperidine >
CBNumber
CB8108748
Molecular Formula
C12H17NO
Formula Weight
191.27
MOL File
91599-81-4.mol
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(R)-(-)-1-Benzyl-3-hydroxypiperidine Property

Boiling point:
275 °C (lit.)
alpha 
-12 º (C=1 IN MEOH)
Density 
1.07 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.547(lit.)
Flash point:
>230 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
clear liquid
pka
14.82±0.20(Predicted)
color 
Light orange to Yellow to Green
optical activity
[α]24/D 12°, c = 1 in methanol
InChI
InChI=1S/C12H17NO/c14-12-7-4-8-13(10-12)9-11-5-2-1-3-6-11/h1-3,5-6,12,14H,4,7-10H2/t12-/m1/s1
InChIKey
UTTCOAGPVHRUFO-GFCCVEGCSA-N
SMILES
N1(CC2=CC=CC=C2)CCC[C@@H](O)C1
CAS DataBase Reference
91599-81-4(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
455172
Product name
(R)-(?)-1-Benzyl-3-hydroxypiperidine
Purity
97%
Packaging
5g
Price
$199
Updated
2023/01/07
TCI Chemical
Product number
B4857
Product name
(R)-1-Benzyl-3-hydroxypiperidine
Purity
>98.0%(GC)
Packaging
1g
Price
$64
Updated
2024/03/01
TCI Chemical
Product number
B4857
Product name
(R)-1-Benzyl-3-hydroxypiperidine
Purity
>98.0%(GC)
Packaging
5g
Price
$194
Updated
2024/03/01
TRC
Product number
B288655
Product name
(R)-1-Benzyl-3-piperidinol
Packaging
100mg
Price
$1230
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB55338
Product name
(R)-1-Benzyl-3-hydroxypiperidine
Packaging
25g
Price
$1300
Updated
2021/12/16
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(R)-(-)-1-Benzyl-3-hydroxypiperidine Chemical Properties,Usage,Production

Uses

(R)-1-Benzyl-3-piperidinol is a benzylpiperidine derivative with hypotensive affects. (R)-1-Benzyl-3-piperidinol is used in the preparation of in vivo probes for measuring endogenous acetylcholine lev els.

Synthesis

40114-49-6

91599-81-4

General procedure for the synthesis of (R)-(-)-1-benzyl-3-hydroxypiperidine using 1-benzyl-3-piperidone as starting material: a reaction mixture was prepared in 1 mL of potassium phosphate buffer (100 mM, pH 7.0) containing 200 mM 1-benzyl-3-piperidone, 1 mM NAD+, 5% (v/v) 2-propanol, and 10 mg of the crude enzyme READH. The reaction mixture warmed at 50°C. For ChKRED20, the reaction conditions were adjusted to 40% (v/v) 2-propanol and 40 °C reaction temperature. The reaction progress was monitored by TLC and the reaction was terminated by extraction with 1 mL of methyl tert-butyl ether. The organic phase was dried with anhydrous sodium sulfate and concentrated. The conversion and enantiomeric excess were determined by chiral HPLC. The products were purified by silica gel column chromatography and structurally characterized by NMR analysis, spinometry and mass spectrometry.

References

[1] Process Biochemistry, 2017, vol. 56, p. 90 - 97

(R)-(-)-1-Benzyl-3-hydroxypiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(-)-1-Benzyl-3-hydroxypiperidine Suppliers

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View Lastest Price from (R)-(-)-1-Benzyl-3-hydroxypiperidine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
(R)-(-)-1-Benzyl-3-hydroxypiperidine 91599-81-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19
Career Henan Chemical Co
Product
(R)-(-)-1-Benzyl-3-hydroxypiperidine 91599-81-4
Price
US $1.80-3.60/KG
Min. Order
1KG
Purity
99%
Supply Ability
88KG
Release date
2019-09-04

91599-81-4, (R)-(-)-1-Benzyl-3-hydroxypiperidineRelated Search:

3-Hydroxypiperidine DROPERIDOL Benzyl benzoate Benzyl acetate Haloperidol Benzoyl peroxide Benzyl alcohol Benzyltriethylammonium chloride Benzyl chloride Benzyltrimethylammonium chloride Diphenoxylate Benidipine hydrochloride Benzyl Benidipine 1-BENZYL-3-HYDROXYPIPERIDINE HYDROCHLORIDE benzyl 3-hydroxypiperidine-1-carboxylate BENZYL 4-HYDROXYPIPERIDINE-1-CARBOXYLATE N-BENZYL-3-HYDROXYPIPERIDINE,1-BENZYL-3-HYDROXYPIPERIDINE,1-BENZYL-3-HYDROXYPIPERIDINE 98%

  • 3-PIPERIDINOL, 1-(PHENYLMETHYL)-, (3R)-
  • (R)-1-BENZYL-PIPERIDIN-3-OL
  • (R)-1-N-BENZYL-3-HYDROXY-PIPERIDINE
  • (R)-(-)-1-BENZYL-3-HYDROXYPIPERIDINE
  • (R)-1-BENZYL-3-HYDROXYPIPERIDINE
  • (R)-1-BENZYL-3-PIPERIDINOL
  • (R)-N-BENZYL-3-HYDROXYPIPERIDINE
  • (R)-(-)-1-BENZYL-3-HYDROXYPIPERIDINE, 97 %
  • (R)-(-)-1-Benzyl-3-hydroxypiperidinol
  • (R)-1-Benzyl-3-hydroxypiperidi
  • (R)-1-(PhenylMethyl)-3-piperidinol
  • )-1-Benzyl-3-hydroxypiperidinol
  • (R)-1-Benzyl-3-hydroxypiperidine &gt
  • (<i>R</i>)-(?)-1-Benzyl-3-hydroxypiperidine
  • 91599-81-4
  • 91599-82-4
  • Chiral Building Blocks
  • Asymmetric Synthesis
  • Piperidines
  • Heterocyclic Building Blocks
  • (intermediate of benidipine)