1H-Benzimidazole-6-carboxaldehyde, 1-methyl- (9CI)
- Product Name
- 1H-Benzimidazole-6-carboxaldehyde, 1-methyl- (9CI)
- CAS No.
- 181867-19-6
- Chemical Name
- 1H-Benzimidazole-6-carboxaldehyde, 1-methyl- (9CI)
- Synonyms
- 3-methylbenzimidazole-5-carbaldehyde;1-Methylbenzimidazole-6-carbaldehyde;3-methyl-5-benzimidazolecarboxaldehyde;1-Methyl-1h-benzimidazole-6-carboxaldehyde;1-Methyl-1H-1,3-benzodiazole-6-carbaldehyde;1H-Benzimidazole-6-carboxaldehyde, 1-methyl-;1-Methyl-1H-benzo[d]imidazole-6-carbaldehyde;1H-Benzimidazole-6-carboxaldehyde, 1-methyl- (9CI)
- CBNumber
- CB81089699
- Molecular Formula
- C9H8N2O
- Formula Weight
- 160.17
- MOL File
- 181867-19-6.mol
1H-Benzimidazole-6-carboxaldehyde, 1-methyl- (9CI) Property
- Boiling point:
- 336.9±34.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- pka
- 4.41±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- M223153
- Product name
- 1-Methyl-1H-benzo[D]imidazole-6-carbaldehyde
- Packaging
- 50mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- W3947
- Product name
- 1-Methyl-1H-benzo[d]imidazole-6-carbaldehyde
- Packaging
- 250mg
- Price
- $384
- Updated
- 2021/12/16
- Product number
- 073419
- Product name
- 1-Methyl-1H-benzo[d]imidazole-6-carbaldehyde
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $878
- Updated
- 2021/12/16
- Product number
- CHM0078016
- Product name
- 1H-BENZIMIDAZOLE-6-CARBOXALDEHYDE, 1-METHYL-
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $1543.08
- Updated
- 2021/12/16
- Product number
- 073419
- Product name
- 1-Methyl-1H-benzo[d]imidazole-6-carbaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1956
- Updated
- 2021/12/16
1H-Benzimidazole-6-carboxaldehyde, 1-methyl- (9CI) Chemical Properties,Usage,Production
Synthesis
64-18-6
64910-49-2
181867-19-6
(d) Synthesis of 1-methyl-1H-benzimidazole-6-carbaldehyde: 4-amino-3-(methylamino)benzonitrile (0.40 g, 2.72 mmol) was dissolved in formic acid (9 mL) and the mixture was heated to 100 °C and maintained for 2 hours. After the reaction was completed, the mixture was cooled to room temperature, nickel ruanne (0.4 g) and water (2 mL) were added, and the mixture was again heated to 100 °C and maintained for 1 hour. Subsequently, the reaction mixture was filtered through diatomaceous earth while hot, the filter cake was washed with methanol, the filtrates were combined and concentrated under reduced pressure. Water (1 mL) was added to the concentrated residue and saturated sodium bicarbonate solution was added slowly and dropwise to neutral. The precipitated solid was collected by filtration, washed with water and dried to afford 1-methyl-1H-benzimidazole-6-carbaldehyde (0.412 g, 95% yield) as a tan solid, which was used directly in the subsequent reaction.1H NMR (CDCl3) data: δ 10.12 (s, 1H), 8.05 (s, 1H), 8.00 (d, J = 0.8 Hz, 1H), and 7.92 (d, J = 8.0 Hz, 1H), 7.84 (dd, J = 1.2, 8.0 Hz, 1H), 3.94 (s, 3H).
References
[1] Patent: WO2005/82901, 2005, A1. Location in patent: Page/Page column 40
1H-Benzimidazole-6-carboxaldehyde, 1-methyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Benzimidazole-6-carboxaldehyde, 1-methyl- (9CI) Suppliers
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