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BOC-MET-OL

Product Name
BOC-MET-OL
CAS No.
51372-93-1
Chemical Name
BOC-MET-OL
Synonyms
BOC-MET-OL;BOC-D-MET-OL;Boc-L-Met-OL;BOC-METHIONINOL;BOC-L-METHIONINOL;N-BOC-L-METHIONINOL;BOC-MET-OL USP/EP/BP;N-ALPHA-T-BOC-L-METHIONINOL;N-T-BUTOXYCARBONYL-L-METHIONINOL;N-(tert-Butoxycarbonyl)-L-Methioninol
CBNumber
CB8118004
Molecular Formula
C10H21NO3S
Formula Weight
235.34
MOL File
51372-93-1.mol
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BOC-MET-OL Property

Melting point:
48.0 to 52.0 °C
storage temp. 
Sealed in dry,2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder to crystal
color 
White to Almost white
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS020096
Product name
N-(tert-Butoxybutoxycarbonyl)-L-methioninol
Purity
Aldrich
Packaging
100mg
Price
$68.1
Updated
2023/06/20
TCI Chemical
Product number
B4283
Product name
N-(tert-Butoxycarbonyl)-L-methioninol
Purity
>95.0%(GC)
Packaging
1g
Price
$35
Updated
2025/07/31
TCI Chemical
Product number
B4283
Product name
N-(tert-Butoxycarbonyl)-L-methioninol
Purity
>95.0%(GC)
Packaging
5g
Price
$106
Updated
2025/07/31
Usbiological
Product number
236443
Product name
Boc-L-methioninol
Packaging
1g
Price
$229
Updated
2021/12/16
Usbiological
Product number
264779
Product name
Boc-L-methioninol
Packaging
500mg
Price
$333
Updated
2021/12/16
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BOC-MET-OL Chemical Properties,Usage,Production

Uses

peptide synthesis

Synthesis

2488-15-5

51372-93-1

General procedure for the synthesis of (S)-2-(tert-butoxycarbonylamino)-4-methylthio-1-butanol from Boc-L-methionine: Boc-L-methionine (49.8 g, 0.5 mol) and 250 mL of tetrahydrofuran (THF) were added to a 500 mL three-neck flask. The reaction mixture was cooled to 0-5 °C in an ice-salt bath with stirring. Sodium borohydride (19 g, 0.5 mol) was slowly added, followed by 50 mL of methanol. Next, 100 mL of tetrahydrofuran solution of iodine (127 g, 0.5 mol) was added dropwise. The reaction system was heated to reflux and the reaction was continuously stirred for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of raw materials, the reaction mixture was cooled in an ice water bath. Saturated ammonium chloride solution was added to quench the reaction. After approximately 100 mL of THF was removed by evaporation using a reduced pressure evaporator, the residue was extracted with ethyl acetate (300 mL). The organic layer was washed sequentially with dilute hydrochloric acid, saturated sodium bicarbonate solution and saturated sodium chloride solution. After drying with anhydrous sodium sulfate, the crude product (120 g) was concentrated to give an oil. The crude product was purified by column chromatography to give the purified product (97.5 g) in 85% yield. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and mass spectrometry (MS): 1H NMR δ 11.64 (br, 1H), 6.85 (br, 1H), 4.55-4.48 (m, 1H), 2.53 (t, J = 4.9 Hz, 2H), 3.44 (s, 3H), 2.05 (s, 3H), 2.02- 1.87 (m, 2H), 1.48 (s, 9H); MS (M + + 1): 236.

References

[1] Antimicrobial Agents and Chemotherapy, 2017, vol. 61, # 3,
[2] Patent: EP2647624, 2013, A1. Location in patent: Paragraph 0059; 0060
[3] Patent: US2013/281695, 2013, A1. Location in patent: Paragraph 0108-0110
[4] Organic Letters, 2005, vol. 7, # 5, p. 847 - 849
[5] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 5, p. 1921 - 1924

BOC-MET-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-MET-OL Suppliers

Americas 1 China 89 Europe 1 Germany 1 India 5 Japan 2 Switzerland 1 United Kingdom 1 United States 14 Global 115
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
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United States
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19552
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Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
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58
Aladdin Scientific
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Email
tp@aladdinsci.com
Country
United States
ProdList
57505
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58
Synthonix Inc
Tel
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Fax
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Email
info@synthonix.com
Country
United States
ProdList
6872
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58
United States Biological
Tel
--
Fax
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Email
chemicals@usbio.net
Country
United States
ProdList
6214
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80
Combi-Blocks Inc.
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--
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Email
sales@combi-blocks.com
Country
United States
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6618
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Riedel-de Haen AG
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TCI America
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sales@tciamerica.com
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6909
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Matrix Scientific
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sales@matrixscientific.com
Country
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Chem-Impex International, Inc.
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INDOFINE Chemical Company, Inc.
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chemical@indofinechemical.com
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United States
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3B Scientific Corporation
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sales@3bsc.com
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AnaSpec, Inc.
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Advanced ChemTech
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View Lastest Price from BOC-MET-OL manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-Met-ol 51372-93-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-02-04

51372-93-1, BOC-MET-OLRelated Search:

BOC-D-ALLO-ILE-OH BOC-MET-OL BOC-MET-OSU BOC-MET-OH DCHA BOC-L-Methionine 4-N-BOC-AMINO-4-CARBOXYTETRAHYDROTHIOPYRAN BOC-MET(O)-OH L-Methioninol BPOC-MET-OH DCHA BOC-HOMOCYS(TRT)-OH (S)-2-(BOC-AMINO)-4-(4-METHYL-BENZYLSULFANYL)BUTYRIC ACID BOC-MET(O2)-OH BOC-2-AMINO-4-(ETHYL(THIO))BUTYRIC ACID BOC-HOCYS(BZL)-OH BOC-L-MET-O-CH2-PHI-CH2-COOH BOC-L-MET(O)-O-CH2-PHI-CH2-COOH DCHA BOC-MET-ONP BOC-L-BUTHIONINESULFOXIMINE

  • N-ALPHA-T-BOC-L-METHIONINOL
  • N-BOC-L-METHIONINOL
  • N-(TERT-BUTOXYBUTOXYCARBONYL)-L-METHIONINOL
  • N-T-BUTOXYCARBONYL-L-METHIONINOL
  • BOC-L-METHIONINOL
  • BOC-MET-OL
  • BOC-METHIONINOL
  • BOC-(S)-2-AMINO-4-METHYLTHIO-1-BUTANOL
  • BOC-D-MET-OL
  • NALPHA-tert-Butoxycarbonyl-L-methioninol
  • (S)-2-t-Butyloxycarbonyl-amino-4-methylthio-1-butanol, N-alpha-t-Butyloxycarbonyl-L-methioninol
  • N-(tert-Butoxycarbonyl)-L-Methioninol
  • Tert-butyl N-[(2s)-1-hydroxy-4-Methylsulfanylbutan-2-yl]carbaMate
  • Boc-L-Met-OL
  • (S)-tert-Butyl(1-hydroxy-4-(methylthio)butan-2-yl)carbamate
  • N-(tert-Butoxycarbonyl)-L-methioninol &gt
  • Carbamic acid, N-[(1S)-1-(hydroxymethyl)-3-(methylthio)propyl]-, 1,1-dimethylethyl ester
  • ert-butylN-[(2S)-1-hydroxy-4-methylsulfanylbutan-2-yl]carbamate
  • (S)-2-(Boc-amino)-4-methylthio-1-butanol
  • (S)-2-(tert-Butoxycarbonyl)amino-4-methylthio-1-butanol
  • BOC-MET-OL USP/EP/BP
  • <i>N</i>-(<i>tert</i>-Butoxybutoxycarbonyl)-<sc>L</sc>-methioninol
  • 51372-93-1
  • C10H21NO3S
  • Amino Acid Derivatives
  • Amino Acids