ChemicalBook > CAS DataBase List > Panitumumab
Panitumumab
- Product Name
- Panitumumab
- CAS No.
- 339177-26-3
- Chemical Name
- Panitumumab
- Synonyms
- Abenix;Abx-egf;Vectibix;Panitumumab;Abx-egf mab;Unii-6A901E312a;Panitumumab USP/EP/BP;Panitumumab (anti-EGFR);Research Grade Panitumumab(DHB86903);Research Grade Pintumomab (DHJ57401)
- CBNumber
- CB81216039
- Formula Weight
- 0
- MOL File
- Mol file
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Panitumumab Property
- storage temp.
- Store at -20°C
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N-Bromosuccinimide Price
DC Chemicals
- Product number
- 013330
- Product name
- Panitumumab
- Packaging
- 001
- Price
- $700
- Updated
- 2021/12/16
DC Chemicals
- Product number
- 013330
- Product name
- Panitumumab
- Packaging
- 003
- Price
- $1900
- Updated
- 2021/12/16
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Panitumumab Chemical Properties,Usage,Production
Description
Panitumumab is a recombinant, fully human IgG2 kappa monoclonal antibody that is highly selective for the epidermal growth factor receptor (EGFR), and it is indicated for the treatment of EGFR-expressing, metastatic colorectal carcinoma (mCRC) with disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Overexpression of EGFR is detected in many human cancers, including those of the colon and rectum. Panitumumab blocks the binding of ligands such as epidermal growth factor (EGF) and transforming growth factor (TGF-a) to various EGFR-expressing cell lines, which results in inhibition of EGF-dependent tumor cell activation, induction of apoptosis, and decreased pro-inflammatory cytokine and vascular growth factor production. In vitro, panitumumab binds EGFR with high affinity (KD ? 50pM; IC50 ? 3 nM) in human cervical epidermal cell line A-431. .
Originator
Abgenix (US)
Uses
Antineoplastic.
brand name
Vectibix
Clinical Use
Monoclonal antibody:
Treatment of metastatic colorectal cancer
Drug interactions
Potentially hazardous interactions with other drugs
Cytotoxics: avoid with bevacizumab, fluorouracil,
irinotecan and oxaliplatin.
Folinic acid: avoid concomitant use.
Live vaccines: avoid concomitant use.
Metabolism
Saturable elimination mediated via reticuloendothelial system, and internalisation and degradation of EGFR.
Panitumumab Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Panitumumab manufacturers
Dideu Industries Group Limited
- Product
- Panitumumab 339177-26-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-02
Shaanxi Dideu Medichem Co. Ltd
- Product
- Panitumumab 339177-26-3
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 800 ton
- Release date
- 2020-04-30
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