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Conivaptan hydrochloride

Product Name
Conivaptan hydrochloride
CAS No.
168626-94-6
Chemical Name
Conivaptan hydrochloride
Synonyms
Vaprisol;Conivaptan HCI;Conivaptan HCl;Unii-75L57R6X36;Conivaptan HCl (YM 087);Conivaptan hydrochkoride;Conivaptan hydrochloride;Conivaptan hydrochloride [usan];Conivaptan hydrochloride, >=99%;Conivaptan hydrochloride USP/EP/BP
CBNumber
CB81246922
Molecular Formula
C32H26N4O2.HCl
Formula Weight
535.04
MOL File
168626-94-6.mol
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Conivaptan hydrochloride Property

Melting point:
>250°
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C32H26N4O2.ClH/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-4-10-22;/h2-18H,19-20H2,1H3,(H,33,34)(H,35,37);1H
InChIKey
BTYHAFSDANBVMJ-UHFFFAOYSA-N
SMILES
C12=CC=CC=C1N(CCC1N=C(C)NC2=1)C(=O)C1=CC=C(NC(=O)C2C=CC=CC=2C2=CC=CC=C2)C=C1.Cl
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23728
Product name
Conivaptan (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
23728
Product name
Conivaptan (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
23728
Product name
Conivaptan (hydrochloride)
Purity
≥95%
Packaging
25mg
Price
$268
Updated
2024/03/01
Cayman Chemical
Product number
23728
Product name
Conivaptan (hydrochloride)
Purity
≥95%
Packaging
50mg
Price
$469
Updated
2024/03/01
Tocris
Product number
6830
Product name
Conivaptanhydrochloride
Purity
≥98%(HPLC)
Packaging
50
Price
$214
Updated
2021/12/16
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Conivaptan hydrochloride Chemical Properties,Usage,Production

Description

Arginine vasopressin is intimately involved in volume homeostasis, and elevated levels of arginine vasopressin are responsible for the pathogenesis and progression of diseases with an imbalance of sodium and water, particularly congestive heart failure. To restore homeostasis, antagonism of vasopressin receptors is a practical solution. As such, conivaptan has been developed and launched as a dual V1a and V2 vasopressin receptor antagonist. As a competitive, reversible inhibitor of both subtypes, conivaptan can modulate systemic vascular resistance through the V1a receptor (Ki ? 0.48 nM) distributed in vascular smooth muscle cells, cardiomyocytes, hepatocytes, and platelets and blocks the renal V2 receptor (Ki ? 3.04 nM) resulting in enhanced diuresis, thereby increasing serum sodium concentration and reducing total body volume. Currently, the drug is approved for the management of refractory hyponatremia and potentially lifethreatening sodium and water imbalance, but it has shown promise as a potential treatment option for other diseases, such as congestive heart failure, syndrome of antidiuretic hormone, diabetes insipidus, and liver cirrhosis.

Description

Conivaptan is an antagonist of the arginine vasopressin (AVP) receptors V1A and V2 (Kis = 0.48 and 3.04 nM for rat liver V1A and kidney V2, respectively). It also competitively inhibits oxytocin binding to rat uterine oxytocin receptors (Ki = 44 nM) but has no effect on AVP binding to anterior pituitary V1B receptors at concentrations up to 100 μM in a radioligand binding assay. Conivaptan suppresses AVP-induced increases in intracellular calcium in vascular smooth muscle cells (VSMCs) in vitro and the pressor response in pithed rats. Conivaptan (0.01-0.3 mg/kg, i.v.) increases urine output and decreases urine osmolality in dehydrated conscious rats in a dose-dependent manner. It also reduces brain edema and blood-brain barrier disruption in a mouse experimental stroke model.

Chemical Properties

White to Off-White Solid

Originator

Yamanouchi (Japan)

Uses

Used in treatment of congestive heart failure.

Uses

Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist).

Definition

ChEBI: The hydrochloride salt of conivaptan. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2, and is used for the treatment of hyponatraemia (low blood sodium levels) cau ed by syndrome of inappropriate antidiuretic hormone (SIADH).

brand name

Vaprisol (Astellas).

storage

Desiccate at RT

Conivaptan hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Conivaptan hydrochloride Suppliers

Canada 1 China 162 India 4 United Kingdom 3 United States 17 Global 187
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from Conivaptan hydrochloride manufacturers

shandong perfect biotechnology co.ltd
Product
Conivaptan HCl 168626-94-6
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
100kg
Release date
2023-08-14
Henan Aochuang Chemical Co.,Ltd.
Product
Conivaptan hydrochloride 168626-94-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-29
Zhuozhou Wenxi import and Export Co., Ltd
Product
Conivaptan hydrochloride 168626-94-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

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