ADRENORPHIN

ChemicalBook > CAS DataBase List > ADRENORPHIN

Product Name: ADRENORPHIN
CAS No.: 88377-68-8
Chemical Name: ADRENORPHIN
Synonyms: METORPHIN;ADRENORPHIN;METORPHAMIDE;METORPHINAMIDE;Adrenorphin(3TFA);adrenorphin amide;Adrenorphin (human);ADRENORPHIN (BOVINE);Adrenorphin (metorphamide);Tyr-Gly-Gly-Phe-Arg-Arg-Val-NH2
CBNumber: CB8129589
Molecular Formula: C44H69N15O9S
Formula Weight: 984.18
MOL File: 88377-68-8.mol

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ADRENORPHIN Property

Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: insoluble in EtOH; ≥48.7 mg/mL in H2O; ≥98.4 mg/mL in DMSO
pka: 9.97±0.15(Predicted)
form: Solid
color: White to off-white
Sequence: H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J66403
Product name: Adrenorphin
Packaging: 1mg
Price: $48.5
Updated: 2021/12/16

Alfa Aesar

Product number: J66403
Product name: Adrenorphin
Packaging: 5mg
Price: $166
Updated: 2021/12/16

ApexBio Technology

Product number: A1032
Product name: Adrenorphin
Packaging: 25mg
Price: $175
Updated: 2021/12/16

ChemScene

Product number: CS-0027637
Product name: Adrenorphin
Purity: 95.49%
Packaging: 5mg
Price: $210
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0000414
Product name: ADRENORPHIN
Purity: 95.00%
Packaging: 1MG
Price: $597.89
Updated: 2021/12/16

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ADRENORPHIN Chemical Properties,Usage,Production

Biological Activity

adrenorphin (metorphamide) is a potent inhibitor of nicotine-induced adrenaline and noradrenaline release with ic50 value of 10 μm [1].adrenorphin (metorphamide) is an endogenous, c-terminally amidated, opioid octapeptide (tyr-gly-gly-phe-met-arg-arg-val-nh2) that is produced from proteolytic cleavage of proenkephalin a and is widely distributed throughout the mammalian brain [2].adrenorphin (metorphamide) is selective nicotine-induced adrenaline and noradrenaline release inhibitor and has higher than 100-fold more potent than the reported nicotine-induced adrenaline and noradrenaline release inhibitor met5-enkephalin. when tested with bovine adrenal chromaffin cells, adrenorphin (metorphamide) showed inhibition on 5 μm nicotine-induced atp release by almost 50% at 5μm and the inhibition was not in a dose-dependent manner [1]. in bioassays and binding assays, metorphamide exhibited high μ-binding activity, as well as κ-binding activity with nearly half percent toμ-binding activity, while showed no activity on δ-binding [2].

References

[1]. marley, p.d., k.i. mitchelhill, and b.g. livett, metorphamide, a novel endogenous adrenal opioid peptide, inhibits nicotine-induced secretion from bovine adrenal chromaffin cells. brain res, 1986. 363(1): p. 10-7.
[2]. weber, e., et al., metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. proc natl acad sci u s a, 1983. 80(23): p. 7362-6.

ADRENORPHIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ADRENORPHIN manufacturers

Career Henan Chemical Co

Product: ADRENORPHIN 88377-68-8
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

88377-68-8, ADRENORPHINRelated Search:

(MET(O)5)-ENKEPHALIN [LEU5]-ENKEPHALIN MET-ENKEPHALIN-ARG-PHE H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-OH MERGL LEU-ENKEPHALIN-ARG MET-ENKEPHALIN-ARG-ARG H-TYR-LYS-GLY-ARG-CYCLO(-GLU-TYR-ILE-LYS)-LEU-ILE-THR-ARG-PRO-ARG-TYR-NH2 ADRENORPHIN (FREE ACID),ADRENORPHIN 1-5-adrenorphin(human ADRENORPHIN BAM 18P PEPTIDE E BAM-12P BAM-22P TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY ([125I]-TYR)-BAM-12P ([125I]-TYR)-BAM-22P

H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2

METORPHIN

METORPHINAMIDE

Adrenorphin(3TFA)

METORPHAMIDE

ADRENORPHIN

ADRENORPHIN (BOVINE)

TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2

PROENKEPHALIN (206-213) (BOVINE)

tyr-gly-gly-phe-met-arg-arg-val amide

TYROSINE-GLYCINE-GLYCINE-PHENYLALANINE-METHIONINE-ARGININE- ARGININE-VALINE AMIDE)

adrenorphin amide

Metorphamide, Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val amide

Tyr-Gly-Gly-Phe-Arg-Arg-Val-NH2

Adrenorphin (metorphamide)

L-Valinamide, L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-

Adrenorphin (human)

Adrenorphin 3TFA(88377-68-8(free base))

Adrenorphin 3TFA(88377688(free base)),Adrenorphin 3TFA(88377 68 8(free base))

88377-68-8

C44H69N15O9S

C44H69N15O9S1

Peptide

CancerBiology