ADRENORPHIN
- Product Name
- ADRENORPHIN
- CAS No.
- 88377-68-8
- Chemical Name
- ADRENORPHIN
- Synonyms
- METORPHIN;ADRENORPHIN;METORPHAMIDE;METORPHINAMIDE;Adrenorphin(3TFA);adrenorphin amide;Adrenorphin (human);ADRENORPHIN (BOVINE);Adrenorphin (metorphamide);Tyr-Gly-Gly-Phe-Arg-Arg-Val-NH2
- CBNumber
- CB8129589
- Molecular Formula
- C44H69N15O9S
- Formula Weight
- 984.18
- MOL File
- 88377-68-8.mol
ADRENORPHIN Property
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- insoluble in EtOH; ≥48.7 mg/mL in H2O; ≥98.4 mg/mL in DMSO
- pka
- 9.97±0.15(Predicted)
- form
- Solid
- Sequence
- H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- J66403
- Product name
- Adrenorphin
- Packaging
- 1mg
- Price
- $48.5
- Updated
- 2021/12/16
- Product number
- J66403
- Product name
- Adrenorphin
- Packaging
- 5mg
- Price
- $166
- Updated
- 2021/12/16
- Product number
- A1032
- Product name
- Adrenorphin
- Packaging
- 25mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- CS-0027637
- Product name
- Adrenorphin
- Purity
- 95.49%
- Packaging
- 5mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- PEP0000414
- Product name
- ADRENORPHIN
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $597.89
- Updated
- 2021/12/16
ADRENORPHIN Chemical Properties,Usage,Production
Biological Activity
adrenorphin (metorphamide) is a potent inhibitor of nicotine-induced adrenaline and noradrenaline release with ic50 value of 10 μm [1].adrenorphin (metorphamide) is an endogenous, c-terminally amidated, opioid octapeptide (tyr-gly-gly-phe-met-arg-arg-val-nh2) that is produced from proteolytic cleavage of proenkephalin a and is widely distributed throughout the mammalian brain [2].adrenorphin (metorphamide) is selective nicotine-induced adrenaline and noradrenaline release inhibitor and has higher than 100-fold more potent than the reported nicotine-induced adrenaline and noradrenaline release inhibitor met5-enkephalin. when tested with bovine adrenal chromaffin cells, adrenorphin (metorphamide) showed inhibition on 5 μm nicotine-induced atp release by almost 50% at 5μm and the inhibition was not in a dose-dependent manner [1]. in bioassays and binding assays, metorphamide exhibited high μ-binding activity, as well as κ-binding activity with nearly half percent toμ-binding activity, while showed no activity on δ-binding [2].
References
[1]. marley, p.d., k.i. mitchelhill, and b.g. livett, metorphamide, a novel endogenous adrenal opioid peptide, inhibits nicotine-induced secretion from bovine adrenal chromaffin cells. brain res, 1986. 363(1): p. 10-7.
[2]. weber, e., et al., metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. proc natl acad sci u s a, 1983. 80(23): p. 7362-6.
ADRENORPHIN Preparation Products And Raw materials
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View Lastest Price from ADRENORPHIN manufacturers
- Product
- ADRENORPHIN 88377-68-8
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18