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ADRENORPHIN

Product Name
ADRENORPHIN
CAS No.
88377-68-8
Chemical Name
ADRENORPHIN
Synonyms
METORPHIN;ADRENORPHIN;METORPHAMIDE;METORPHINAMIDE;Adrenorphin(3TFA);adrenorphin amide;Adrenorphin (human);ADRENORPHIN (BOVINE);Adrenorphin (metorphamide);Tyr-Gly-Gly-Phe-Arg-Arg-Val-NH2
CBNumber
CB8129589
Molecular Formula
C44H69N15O9S
Formula Weight
984.18
MOL File
88377-68-8.mol
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ADRENORPHIN Property

Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
insoluble in EtOH; ≥48.7 mg/mL in H2O; ≥98.4 mg/mL in DMSO
pka
9.97±0.15(Predicted)
form 
Solid
color 
White to off-white
Sequence
H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J66403
Product name
Adrenorphin
Packaging
1mg
Price
$48.5
Updated
2021/12/16
Alfa Aesar
Product number
J66403
Product name
Adrenorphin
Packaging
5mg
Price
$166
Updated
2021/12/16
ChemScene
Product number
CS-0027637
Product name
Adrenorphin
Purity
95.49%
Packaging
1mg
Price
$70
Updated
2021/12/16
ApexBio Technology
Product number
A1032
Product name
Adrenorphin
Packaging
5mg
Price
$75
Updated
2021/12/16
ApexBio Technology
Product number
A1032
Product name
Adrenorphin
Packaging
10mg
Price
$125
Updated
2021/12/16
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ADRENORPHIN Chemical Properties,Usage,Production

Biological Activity

adrenorphin (metorphamide) is a potent inhibitor of nicotine-induced adrenaline and noradrenaline release with ic50 value of 10 μm [1].adrenorphin (metorphamide) is an endogenous, c-terminally amidated, opioid octapeptide (tyr-gly-gly-phe-met-arg-arg-val-nh2) that is produced from proteolytic cleavage of proenkephalin a and is widely distributed throughout the mammalian brain [2].adrenorphin (metorphamide) is selective nicotine-induced adrenaline and noradrenaline release inhibitor and has higher than 100-fold more potent than the reported nicotine-induced adrenaline and noradrenaline release inhibitor met5-enkephalin. when tested with bovine adrenal chromaffin cells, adrenorphin (metorphamide) showed inhibition on 5 μm nicotine-induced atp release by almost 50% at 5μm and the inhibition was not in a dose-dependent manner [1]. in bioassays and binding assays, metorphamide exhibited high μ-binding activity, as well as κ-binding activity with nearly half percent toμ-binding activity, while showed no activity on δ-binding [2].

References

[1]. marley, p.d., k.i. mitchelhill, and b.g. livett, metorphamide, a novel endogenous adrenal opioid peptide, inhibits nicotine-induced secretion from bovine adrenal chromaffin cells. brain res, 1986. 363(1): p. 10-7.
[2]. weber, e., et al., metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. proc natl acad sci u s a, 1983. 80(23): p. 7362-6.

ADRENORPHIN Preparation Products And Raw materials

Raw materials

Preparation Products

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ADRENORPHIN Suppliers

Alabiochem Tech.Co., Ltd.
Tel
0512-58900862 400-0707518
Fax
0086-512-56765862
Email
sales@alabiochem.com
Country
China
ProdList
995
Advantage
59
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
ApexBio Technology LLC
Tel
+1-832-696-8203
Fax
+1-832-641-3177
Email
info@apexbt.com
Country
United States
ProdList
477
Advantage
60
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Alabiotech Inc.
Tel
001-619-354-5251
Fax
001-855-855-6087
Email
sales@alabiotech-e.com
Country
United States
ProdList
972
Advantage
60
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55
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View Lastest Price from ADRENORPHIN manufacturers

Career Henan Chemical Co
Product
ADRENORPHIN 88377-68-8
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-18

88377-68-8, ADRENORPHINRelated Search:


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