(1-Methyl-1H-benzoimidazol-2-yl)acetonitrile
- Product Name
- (1-Methyl-1H-benzoimidazol-2-yl)acetonitrile
- CAS No.
- 2735-62-8
- Chemical Name
- (1-Methyl-1H-benzoimidazol-2-yl)acetonitrile
- Synonyms
- 1-Methyl-2-benziMidazolylacetonitrile;1-Methyl-1H-benzimidazole-2-acetonitrile;2-(1-methylbenzimidazol-2-yl)acetonitrile;1-Methyl-1H-benzodimidazol-2-acetonitrile;1-Methyl-2-(cyanomethyl)-1H-benzoimidazole;2-(1-methylbenzimidazol-2-yl)ethanenitrile;1H-Benzimidazole-2-acetonitrile, 1-methyl-;(1-METHYL-1H-BENZIMIDAZOL-2-YL)ACETONITRILE;(1-Methyl-1H-benzoimidazol-2-yl)acetonitrile;1H-Benzimidazole-2-acetonitrile,1-methyl-(9CI)
- CBNumber
- CB81302613
- Molecular Formula
- C10H9N3
- Formula Weight
- 171.2
- MOL File
- 2735-62-8.mol
(1-Methyl-1H-benzoimidazol-2-yl)acetonitrile Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light brown Solid
- EPA Substance Registry System
- 1-Methyl-2-benzimidazoleacetonitrile (2735-62-8)
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M291115
- Product name
- (1-Methyl-1h-benzoimidazol-2-yl)acetonitrile
- Packaging
- 250mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- OR951177
- Product name
- (1-Methyl-1H-benzoimidazol-2-yl)acetonitrile
- Purity
- 95%
- Packaging
- 250mg
- Price
- $269
- Updated
- 2021/12/16
- Product number
- 3H37-1-86
- Product name
- (1-Methyl-1H-benzoimidazol-2-yl)acetonitrile
- Purity
- 95%
- Packaging
- 250mg
- Price
- $296
- Updated
- 2021/12/16
- Product number
- 2588AB
- Product name
- 2-(1-Methyl-1H-benzo[d]imidazol-2-yl)acetonitrile
- Packaging
- 250mg
- Price
- $302
- Updated
- 2021/12/16
- Product number
- 135460
- Product name
- 2-(1-Methyl-1H-benzo[d]imidazol-2-yl)acetonitrile
- Purity
- 95%+
- Packaging
- 1g
- Price
- $436
- Updated
- 2021/12/16
(1-Methyl-1H-benzoimidazol-2-yl)acetonitrile Chemical Properties,Usage,Production
Synthesis
4414-88-4
77-78-1
2735-62-8
The general procedure for the synthesis of 2-(1-methyl-1H-benzo[d]imidazol-2-yl)acetonitrile from 2-cyanomethylbenzimidazole and dimethyl sulfate was as follows: 1.2 equivalents of dimethyl sulfate was added drop-wise to a mixture containing benzimidazol-2-ylacetonitrile (3b) and 1.1 equivalents of aqueous sodium hydroxide, and the temperature of the reaction was maintained at 30 °C, with continuous stirring for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and the precipitate was collected by filtration, washed several times with deionized water and subsequently dried. The yield of the final product was 78%.
References
[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 9, p. 2053 - 2059
[2] Synthetic Communications, 2007, vol. 37, # 13, p. 2259 - 2266
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 1, p. 238 - 252
[4] Angewandte Chemie - International Edition, 2014, vol. 53, # 27, p. 7079 - 7084
[5] Angew. Chem., 2014, vol. 126, # 27, p. 7199 - 7204,6
(1-Methyl-1H-benzoimidazol-2-yl)acetonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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