Muromonab-CD3
- Product Name
- Muromonab-CD3
- CAS No.
- 140608-64-6
- Chemical Name
- Muromonab-CD3
- Synonyms
- Muromonab-CD3;Muromonab (anti-CD3);Muromonab-CD3 USP/EP/BP;Research Grade Muromonab;Research Grade Muromonab-Cd3;Research Grade Muromonab(DHC27701)
- CBNumber
- CB81341724
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- ATB0023423
- Product name
- MUROMONAB-CD3
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.91
- Updated
- 2021/12/16
Muromonab-CD3 Chemical Properties,Usage,Production
Description
Muromonab-CD3 is a murine monoclonal antibody to the T3 antigen of human T-cells, which blocks their killing ability. It is useful in the treatment of acute allograft rejection in renal transplant patients.
Originator
Ortho (USA)
Uses
Monoclonal antibody (immunosuppressant).
brand name
Orthoclone OKT3 (Ortho Pharmaceutical);ORTHOCLONE OKT3.
General Description
Muromonab-CD3 (murine, Orthoclone-OKT3) is an unmodified mouse immunoglobulin, an IgG2a, monoclonal. It binds a glycoprotein on the surface of mature T lymphocytes. Mature T cells have, as part of the signal transduction machinery of the T-cell receptor complex, a set of three glycoproteins that are collectively called CD3. Together with the protein zeta, the CD3 molecules become phosphorylated when the T-cell receptor is bound to a peptide fragment and the major histocompatibility complex. The phosphorylated CD3 and zeta molecules transmit information into the cell, ultimately producing transcription factors that enter the nucleus and direct the T-cell activity. By binding to CD3, muromonab-CD3 prevents signal transduction into T cells.
Muromonab-CD3 blocks the function of T cells thatare involved in acute renal rejection. Hence, it is indicatedfor the treatment of acute allograft rejection in heart andliver transplant recipients resistant to standard steroidtherapies.
Mechanism of action
Muromonab-(CD3) alters the cell-mediated immune response by binding to the CD3 (cluster of differentiation antigen, T3) glycoprotein on T lymphocytes. This binding inhibits lymphocyte activation so that affected T cells cannot recognize foreign antigen and cannot participate in rejecting an organ graft.Within minutes of the first muromonab-(CD3) injection, total circulating T cells are rapidly depleted from the blood. They later reappear devoid of CD3 and antigen recognition complexes.
Clinical Use
Muromonab-(CD3) (Orthoclone OKT3) is a mouse monoclonal antibody that is a purified IgG. It is used for the prevention of acute allograft rejection in kidney and hepatic transplants and as prophylaxis in cardiac transplantation. It is also used to deplete T cells in marrow from donors before bone marrow transplantation.
Side effects
Adverse side effects include fever, pulmonary edema, vomiting, headache, and anaphylaxis. Neutralizing antibodies may develop over time and necessitate adjusting the dosage upward to compensate for the loss of therapeutic activity.
Muromonab-CD3 Preparation Products And Raw materials
Raw materials
Preparation Products
Muromonab-CD3 Suppliers
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View Lastest Price from Muromonab-CD3 manufacturers
- Product
- Muromonab-CD3 140608-64-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-17