Foralumab
- Product Name
- Foralumab
- CAS No.
- 946415-64-1
- Chemical Name
- Foralumab
- Synonyms
- Foralumab;Foralumab (anti-CD3E);Research Grade Foralumab;Research Grade Foralumab(DHC27705)
- CBNumber
- CB68080819
- Formula Weight
- 0
- MOL File
- Mol file
Foralumab Property
- form
- Liquid
- color
- Colorless to light yellow
Foralumab Chemical Properties,Usage,Production
Uses
Foralumab (NI-0401) is a potent, orally active human monoclonal antibody targeting the CD3. Foralumab modulates immune responses by human cells in NSG mice that were reconstituted with human hematopoietic stem cells[1].
in vivo
Foralumab (NI-0401; 0.6-250 μg; p.o.; daily, for 5 d) delays the rejection of B6Rag2?/? skin grafted onto the humanized mice[1].
Foralumab (0.6-250 μg; p.o. and i.h.; daily, for 5 d) prevents skin xenograft rejection in mice with human immune systems[1].
Foralumab (1-15 μg; p.o.; daily, for 5 d) has good bioavailability of intragastric in humanized mice[1].
| Animal Model: | Humanized NOD/SCID IL-2γc?/? mice with Skin grafts (Humanized mice: CD34+ cells are injected intra-hepatically into irradiated (0.9 Gy) NSG pups within 48 hours of birth) [1] |
| Dosage: | 15 μg |
| Administration: | Oral administration; daily, for 5 days and weekly dosing |
| Result: | Showed robust protection against graft rejection and prolongs graft survival. Reduced proliferation of CD8+ T cells and reduced release of TNF. Increased the concentration of IL-10. |
| Animal Model: | Humanized NOD/SCID IL-2γc?/? mice with Skin grafts (Humanized mice: CD34+ cells are injected intra-hepatically into irradiated (0.9 Gy) NSG pups within 48 hours of birth) [1] |
| Dosage: | 1, 5, 15, 50, and 250 μg (p.o.), 0.6 mg/kg (i.h.) |
| Administration: | Oral administration and subcutaneous injection; daily, for 5 days and weekly dosing |
| Result: | Had tolerant to autologous skin grafts in humanized mice. |
| Animal Model: | Humanized NOD/SCID IL-2γc?/? mice with Skin grafts (Humanized mice: CD34+ cells are injected intra-hepatically into irradiated (0.9 Gy) NSG pups within 48 hours of birth) [1] |
| Dosage: | 0, 5, 10, and 15 μg |
| Administration: | Oral administration and subcutaneous injection; daily, for 5 days and weekly dosing |
| Result: | Increased human Ig on the surface of CD4+ and CD8+ T cells. Had free mAb in the serum of mice |
References
[1] Ogura M, et, al. Oral treatment with foralumab, a fully human anti-CD3 monoclonal antibody, prevents skin xenograft rejection in humanized mice. Clin Immunol. 2017 Oct;183:240-246. DOI:10.1016/j.clim.2017.07.005
Foralumab Preparation Products And Raw materials
Raw materials
Preparation Products
Foralumab Suppliers
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8000
- Advantage
- 62
- Tel
- 15817493340
- 981810490@qq.com
- Country
- China
- ProdList
- 1566
- Advantage
- 58
- Tel
- 027-65317797 15926423062
- Fax
- QQ：422450190
- 422450190@qq.com
- Country
- China
- ProdList
- 10308
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 027-65279366 18108604356
- products@biolabreagent.com
- Country
- China
- ProdList
- 9868
- Advantage
- 58
- Tel
- 13720134139 086-15871494362 13720134139
- orders@jknbiochem.com
- Country
- China
- ProdList
- 6762
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
- Country
- China
- ProdList
- 11973
- Advantage
- 58
- Tel
- 0731-13823398 15111215862
- 313359644@qq.com
- Country
- China
- ProdList
- 4161
- Advantage
- 58
- Tel
- 0573-83568680 18057391398
- 3956524501@qq.com
- Country
- China
- ProdList
- 1442
- Advantage
- 58