3-AMINO-6-METHOXYPYRIDAZINE
- Product Name
- 3-AMINO-6-METHOXYPYRIDAZINE
- CAS No.
- 7252-84-8
- Chemical Name
- 3-AMINO-6-METHOXYPYRIDAZINE
- Synonyms
- 6-methoxypyridazin-3-amine;3-PyridazinaMine, 6-Methoxy-;NSC 73703;EOS-62222;Netarsudil Impurity 12;6-Methoxy-3-pyridazinamine;6-Amino-3-methoxypyridazine;3-Methoxy-6-aminopyridazine;3-AMINO-6-METHOXYPYRIDAZINE;6-Methoxy-pyridazin-3-ylamine
- CBNumber
- CB8134491
- Molecular Formula
- C5H7N3O
- Formula Weight
- 125.13
- MOL File
- 7252-84-8.mol
3-AMINO-6-METHOXYPYRIDAZINE Property
- Melting point:
- 108-109℃
- Boiling point:
- 353.5±22.0 °C(Predicted)
- Density
- 1.224
- storage temp.
- 2-8°C(protect from light)
- form
- Solid
- pka
- 5.84±0.10(Predicted)
- InChI
- InChI=1S/C5H7N3O/c1-9-5-3-2-4(6)7-8-5/h2-3H,1H3,(H2,6,7)
- InChIKey
- YPWBPONDYDVMLX-UHFFFAOYSA-N
- SMILES
- C1(N)=NN=C(OC)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A612073
- Product name
- 3-Amino-6-methoxypyridazine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4H56-1-2N
- Product name
- 3-Amino-6-methoxypyridazine
- Packaging
- 1g
- Price
- $76
- Updated
- 2021/12/16
- Product number
- CS-0019296
- Product name
- 3-Amino-6-methoxypyridazine
- Purity
- 99.91%
- Packaging
- 10g
- Price
- $79
- Updated
- 2021/12/16
- Product number
- 4H56-1-2N
- Product name
- 3-Amino-6-methoxypyridazine
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 072012
- Product name
- 3-Amino-6-methoxypyridazine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $41
- Updated
- 2021/12/16
3-AMINO-6-METHOXYPYRIDAZINE Chemical Properties,Usage,Production
Description
3-amino-6-methoxypyridazine: a critical pharmaceutical intermediate.
It can be used for pyridopyrimidine compounds with remarkable biological activity or medicines, such as the anticancer drug Ruugeli, which can be used for treating indications such as pain caused by endometriosis, uterine fibroids and advanced prostate cancer. At present, many reports on the preparation method of the compound exist, and various process impurities such as 3-amino-6-chloropyridazine, 3-amino-6-hydroxypyridazine, 3-chloro-6-hydroxypyridazine, 3-dichloropyridazine, 3, 6-dimethoxypyridazine, 3-amino-6-methoxypyridazine, 3-aminopyridazine and the like are often introduced in the process of the conventional synthesis process.
Uses
3-Amino-6-methoxypyridazine is an organic reagent that can be used as a key intermediate in the preparation of Relugoli.
Synthesis
A total of 3.40 g. (0.026 mol) 3-amino-6-chloropyridazine was placed in a Carius tube with a solution of sodium methoxide in methanol [prepared from 0.61 g. (0.027 mol) of clean sodium metal and 50 ml. of methanol], and the Carius tube was sealed. The tube was placed in a Carius furnace for 20 hours. After the tube was cooled and opened, the contents were removed, and the light brown solid was filtered off. The filtrate was evaporated to dryness at room temperature under an air jet. The resulting orange-brown crystalline solid was dissolved in a 60:40 petroleum ether-chloroform solution, treated with activated charcoal and filtered. There was obtained, upon. Talline solid fromn-amyl chloride accompanied by treat- 3 ment with activated charcoal yielded 0.51 g. of a white, crystalline solid 3-amino-6-methoxypyridazine melting at 103-105 ℃.
3-AMINO-6-METHOXYPYRIDAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
3-AMINO-6-METHOXYPYRIDAZINE Suppliers
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View Lastest Price from 3-AMINO-6-METHOXYPYRIDAZINE manufacturers
- Product
- 3-Amino-6-methoxypyridazine 7252-84-8
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2024-10-23
- Product
- Relugolix Impurity 5 7252-84-8
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-08-13
- Product
- 3-AMINO-6-METHOXYPYRIDAZINE 7252-84-8
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09