asterric acid

Product Name: asterric acid
CAS No.: 577-64-0
Chemical Name: asterric acid
Synonyms: asterric acid;DiMethylosoic acid,TAN 1415A, WF 12880A;2-(2-Methoxycarbonyl-4-hydroxy-6-methoxyphenoxy)-4-methyl-6-hydroxybenzoic acid;Benzoic acid, 2-(2-carboxy-3-hydroxy-5-methylphenoxy)-5-hydroxy-3-methoxy-, 1-methyl ester
CBNumber: CB81365102
Molecular Formula: C17H16O8
Formula Weight: 348.3
MOL File: 577-64-0.mol

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asterric acid Property

Melting point:: 208-214 °C
Boiling point:: 557.6±50.0 °C(Predicted)
Density: 1.406±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in ethanol;Soluble in DMSO;Soluble in dimethyl formamide
form: solid
pka: 2.97±0.34(Predicted)
color: white

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Safety

Hazard Codes: N
Risk Statements: 50
Safety Statements: 61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00012
Product name: Asterric acid
Purity: ≥95% (LC/MS-ELSD)
Packaging: 1mg
Price: $407
Updated: 2024/03/01

Cayman Chemical

Product number: 70630
Product name: Asterric Acid
Purity: ≥99%
Packaging: 1mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 70630
Product name: Asterric Acid
Purity: ≥99%
Packaging: 5mg
Price: $796
Updated: 2024/03/01

TRC

Product number: A790158
Product name: Asterric acid
Packaging: 1mg
Price: $160
Updated: 2021/12/16

Usbiological

Product number: A3884
Product name: Asterric Acid
Packaging: 1mg
Price: $460
Updated: 2021/12/16

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asterric acid Chemical Properties,Usage,Production

Uses

Asterric acid is a fungal metabolite with anti-angiogenic properties, isolated from a number of Aspergillus and Penicillium species. It is an inhibitor of vascular endothelial growth factor (VEGF), inhibiting VEGF-induced tube formation of human umbilical vein endothelial cells.

Biological Activity

asterric acid is an eta receptor inhibitor.endothelin (et), a potent vasoconstrictor/pressor peptide consisting of 21 amino acid residues, was first isolated from the cultures of porcine aortic endothelial cells. analyses of a human genomic library reveals three forms of et (et-1, et-2 and et-3) with more than 70% homology with one another. in various organs, high affinity and specific receptors for et have been found, which have been classfied as receptors eta and etb. et-1 has potent and long-lasting vasoconstrictive activity, as a result of binding to the eta receptor.

in vitro

previous study asterric acid isolated as an active substance from the culture filtrate of a fungus, aspergillus sp. asterric acid had also been reported as a metabolite of a fungus. it was found that asterric acid had the property of inhibiting et-1 binding to the eta receptor of a10 cells, but it showed no inhibitory activity against anp and a ii binding at 10 mm, which indicated that asterric acid displayed as a specific inhibitor of et-1 binding [1].

IC 50

10 μm for et-1 binding to the eta receptor ofa10 cells

References

[1] ohashi, h. ,akiyama, h.,nishikori, k., et al. asterric acid, a new endothelin binding inhibitor. journal of antibiotics 45, 1684-1685 (1992).

asterric acid Preparation Products And Raw materials

Raw materials

Preparation Products

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asterric acid Suppliers

China 14 India 1 United Kingdom 1 United States 6 Global 22

Lynnchem

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TargetMol Chemicals Inc.

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Email: marketing@targetmol.com
Country: United States
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Energy Chemical

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577-64-0, asterric acidRelated Search:

METHYL 2-PHENOXYBENZOATE 2,6-Dihydroxybenzoic acid BIS(2-FORMYLPHENYL) ETHER 2,5-Dihydroxybenzoic acid 3-Methoxysalicylic acid Methyl 3-methoxysalicylate 2-METHOXY-4-METHYLBENZOIC ACID 2,3-Dimethoxybenzoic acid 2,3-Dihydroxybenzoic acid methyl 2,3-dihydroxybenzoate methyl 5-hydroxy-2-methoxybenzoate 2-PHENOXYBENZOIC ACID Methyl 2,5-dihydroxybenzoate 4-Methylsalicylic acid asterric acid 2,6-DIHYDROXY-4-METHYLBENZALDEHYDE 3-HYDROXY-6-METHOXYBENZOIC ACID 2,6-DIHYDROXY-4-METHYLBENZOIC ACID

asterric acid

2-(2-Methoxycarbonyl-4-hydroxy-6-methoxyphenoxy)-4-methyl-6-hydroxybenzoic acid

DiMethylosoic acid,TAN 1415A, WF 12880A

Benzoic acid, 2-(2-carboxy-3-hydroxy-5-methylphenoxy)-5-hydroxy-3-methoxy-, 1-methyl ester

577-64-0