asterric acid
- Product Name
- asterric acid
- CAS No.
- 577-64-0
- Chemical Name
- asterric acid
- Synonyms
- asterric acid;DiMethylosoic acid,TAN 1415A, WF 12880A;2-(2-Methoxycarbonyl-4-hydroxy-6-methoxyphenoxy)-4-methyl-6-hydroxybenzoic acid;Benzoic acid, 2-(2-carboxy-3-hydroxy-5-methylphenoxy)-5-hydroxy-3-methoxy-, 1-methyl ester
- CBNumber
- CB81365102
- Molecular Formula
- C17H16O8
- Formula Weight
- 348.3
- MOL File
- 577-64-0.mol
asterric acid Property
- Melting point:
- 208-214 °C
- Boiling point:
- 557.6±50.0 °C(Predicted)
- Density
- 1.406±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in ethanol;Soluble in DMSO;Soluble in dimethyl formamide
- form
- solid
- pka
- 2.97±0.34(Predicted)
- color
- white
N-Bromosuccinimide Price
- Product number
- SMB00012
- Product name
- Asterric acid
- Purity
- ≥95% (LC/MS-ELSD)
- Packaging
- 1mg
- Price
- $407
- Updated
- 2024/03/01
- Product number
- 70630
- Product name
- Asterric Acid
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- 70630
- Product name
- Asterric Acid
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $796
- Updated
- 2024/03/01
- Product number
- A790158
- Product name
- Asterric acid
- Packaging
- 1mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- A3884
- Product name
- Asterric Acid
- Packaging
- 1mg
- Price
- $460
- Updated
- 2021/12/16
asterric acid Chemical Properties,Usage,Production
Uses
Asterric acid is a fungal metabolite with anti-angiogenic properties, isolated from a number of Aspergillus and Penicillium species. It is an inhibitor of vascular endothelial growth factor (VEGF), inhibiting VEGF-induced tube formation of human umbilical vein endothelial cells.
Biological Activity
asterric acid is an eta receptor inhibitor.endothelin (et), a potent vasoconstrictor/pressor peptide consisting of 21 amino acid residues, was first isolated from the cultures of porcine aortic endothelial cells. analyses of a human genomic library reveals three forms of et (et-1, et-2 and et-3) with more than 70% homology with one another. in various organs, high affinity and specific receptors for et have been found, which have been classfied as receptors eta and etb. et-1 has potent and long-lasting vasoconstrictive activity, as a result of binding to the eta receptor.
in vitro
previous study asterric acid isolated as an active substance from the culture filtrate of a fungus, aspergillus sp. asterric acid had also been reported as a metabolite of a fungus. it was found that asterric acid had the property of inhibiting et-1 binding to the eta receptor of a10 cells, but it showed no inhibitory activity against anp and a ii binding at 10 mm, which indicated that asterric acid displayed as a specific inhibitor of et-1 binding [1].
IC 50
10 μm for et-1 binding to the eta receptor ofa10 cells
References
[1] ohashi, h. ,akiyama, h.,nishikori, k., et al. asterric acid, a new endothelin binding inhibitor. journal of antibiotics 45, 1684-1685 (1992).