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asterric acid

Product Name
asterric acid
CAS No.
577-64-0
Chemical Name
asterric acid
Synonyms
asterric acid;DiMethylosoic acid,TAN 1415A, WF 12880A;2-(2-Methoxycarbonyl-4-hydroxy-6-methoxyphenoxy)-4-methyl-6-hydroxybenzoic acid;Benzoic acid, 2-(2-carboxy-3-hydroxy-5-methylphenoxy)-5-hydroxy-3-methoxy-, 1-methyl ester
CBNumber
CB81365102
Molecular Formula
C17H16O8
Formula Weight
348.3
MOL File
577-64-0.mol
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asterric acid Property

Melting point:
208-214 °C
Boiling point:
557.6±50.0 °C(Predicted)
Density 
1.406±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in ethanol;Soluble in DMSO;Soluble in dimethyl formamide
form 
solid
pka
2.97±0.34(Predicted)
color 
white
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Safety

Hazard Codes 
N
Risk Statements 
50
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB00012
Product name
Asterric acid
Purity
≥95% (LC/MS-ELSD)
Packaging
1mg
Price
$407
Updated
2024/03/01
Cayman Chemical
Product number
70630
Product name
Asterric Acid
Purity
≥99%
Packaging
1mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
70630
Product name
Asterric Acid
Purity
≥99%
Packaging
5mg
Price
$796
Updated
2024/03/01
TRC
Product number
A790158
Product name
Asterric acid
Packaging
1mg
Price
$160
Updated
2021/12/16
Usbiological
Product number
A3884
Product name
Asterric Acid
Packaging
1mg
Price
$460
Updated
2021/12/16
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asterric acid Chemical Properties,Usage,Production

Uses

Asterric acid is a fungal metabolite with anti-angiogenic properties, isolated from a number of Aspergillus and Penicillium species. It is an inhibitor of vascular endothelial growth factor (VEGF), inhibiting VEGF-induced tube formation of human umbilical vein endothelial cells.

Biological Activity

asterric acid is an eta receptor inhibitor.endothelin (et), a potent vasoconstrictor/pressor peptide consisting of 21 amino acid residues, was first isolated from the cultures of porcine aortic endothelial cells. analyses of a human genomic library reveals three forms of et (et-1, et-2 and et-3) with more than 70% homology with one another. in various organs, high affinity and specific receptors for et have been found, which have been classfied as receptors eta and etb. et-1 has potent and long-lasting vasoconstrictive activity, as a result of binding to the eta receptor.

in vitro

previous study asterric acid isolated as an active substance from the culture filtrate of a fungus, aspergillus sp. asterric acid had also been reported as a metabolite of a fungus. it was found that asterric acid had the property of inhibiting et-1 binding to the eta receptor of a10 cells, but it showed no inhibitory activity against anp and a ii binding at 10 mm, which indicated that asterric acid displayed as a specific inhibitor of et-1 binding [1].

IC 50

10 μm for et-1 binding to the eta receptor ofa10 cells

References

[1] ohashi, h. ,akiyama, h.,nishikori, k., et al. asterric acid, a new endothelin binding inhibitor. journal of antibiotics 45, 1684-1685 (1992).

asterric acid Preparation Products And Raw materials

Raw materials

Preparation Products

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