LUPULONE
- Product Name
- LUPULONE
- CAS No.
- 468-28-0
- Chemical Name
- LUPULONE
- Synonyms
- lupulon;b’’-acid;LUPULONE;B-LUPULIC ACID;lohexadien-1-one;BETA-BITTER ACID;BETA-LUPULIC ACID;Lupulone beta-acid;Coclaurine Impurity 3;Lupulone (stable DCHA salt)
- CBNumber
- CB8136556
- Molecular Formula
- C26H38O4
- Formula Weight
- 414.58
- MOL File
- 468-28-0.mol
LUPULONE Property
- Melting point:
- 93℃
- Boiling point:
- 453.43°C (rough estimate)
- Density
- 1.045±0.06 g/cm3 (20 ºC 760 Torr)
- vapor pressure
- 0Pa at 20℃
- refractive index
- 1.4840 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Methanol: slightly soluble
- form
- A solid
- pka
- 4.50±1.00(Predicted)
- color
- White to off-white
- Water Solubility
- 1g/L at 20℃
- Stability:
- Hygroscopic
- Major Application
- food and beverages
pharmaceutical - LogP
- 4.5 at 20℃
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 28481
- Product name
- Lupulone
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 28481
- Product name
- Lupulone
- Packaging
- 10mg
- Price
- $384
- Updated
- 2024/03/01
- Product number
- 28481
- Product name
- Lupulone
- Packaging
- 5mg
- Price
- $202
- Updated
- 2024/03/01
- Product number
- L478000
- Product name
- Lupulone
- Packaging
- 10mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- FL74820
- Product name
- Lupulone
- Packaging
- 10mg
- Price
- $300
- Updated
- 2021/12/16
LUPULONE Chemical Properties,Usage,Production
Uses
Lupulone is a hop plant (Humulus lupulus L.) acid that inhibits tumorigenicity of hepatocellular carcinoma cells.
Definition
ChEBI: Lupulone is a beta-bitter acid in which the acyl group is specified as 3-methylbutanoyl. It has a role as an antimicrobial agent, an apoptosis inducer, an angiogenesis inhibitor and an antineoplastic agent. It is a conjugate acid of a lupulone(1-).
Synthesis
The process for the extraction and isolation of Lupulone from hops is as follows: Step a, the hops compression is loaded into a subcritical ultrasonic extractor, the appropriate temperature and pressure are selected, the R134a mixed solvent is passed into the extractor, the active ingredients in the extracted substance are dissolved in the liquid or subcritical state of the R134a mixed solvent, and the resulting extract is filtered through the filter, and the filtrate is pumped into the separator. Step b, the temperature and pressure are adjusted so that the R134a in the R134a mixed solvent is converted from liquid state to gas state and separated from the extract, and the extract containing methanol is concentrated by the concentrating evaporator to obtain the hop extract, which enters into the analyzing crystallization section. The solvent (R134a, methanol) obtained from evaporation is recovered by condensation system and returned to the extraction device for recycling. Step c, take a certain amount of hop extract in a reactor, add water according to the weight ratio of hop extract:water=1:2, adjust the pH to 8.5-9.0 with 10% NaOH at a temperature of 45??-50??, stir for 30min, and let it stand at room temperature for 6h, extract and filter, and collect insoluble matter. Step d, the insoluble material was added to water at the weight ratio of insoluble material:water = 1:10, and the pH was adjusted to 12.5 to 13.0 with 10% NaOH at 45??C to 50??C, stirred for 30 min, and allowed to stand for 6h at room temperature, and filtered. Step e, the filtrate with dilute phosphoric acid to adjust the pH value to 8.5, stirring for 30min, filtration, the collection of insoluble material, that is, to obtain the crude serpentine ketone; hexane on the serpentine ketone crude recrystallization of the white needle state Lupulone.
Purification Methods
Crystallise Lupulon from 90% MeOH, hexane or pet ether at low temperature. It has also been purified by chromatography through Kieselgel. [Wieland et al. Chem Ber 102 2012 1925, Riedl Chem Ber 85 692 1952, Beilstein 7 II 856, 7 III 4752, 7 IV 2866.]
LUPULONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from LUPULONE manufacturers
- Product
- LUPULONE 468-28-0
- Price
- US $1.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KG
- Release date
- 2024-07-25
- Product
- LUPULONE 468-28-0
- Price
- US $1.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KG
- Release date
- 2024-07-25
- Product
- Lupulone 468-28-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10