ChemicalBook > CAS DataBase List > E 7010

E 7010

Product Name: E 7010
CAS No.: 141430-65-1
Chemical Name: E 7010
Synonyms: E 7010;CS-505;CS-1806;ABT-751 (E;E7010(ABT-751);ABT-751 ABT751;ABT-751 (E7010);ABT-751, 10 mM in DMSO;E 7010 ISO 9001：2015 REACH;ABT-751 (E7010);ABT751; ABT 751
CBNumber: CB81367030
Molecular Formula: C18H17N3O4S
Formula Weight: 371.41
MOL File: 141430-65-1.mol

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E 7010 Property

Melting point:: 162 °C(dec.)
Boiling point:: 551.0±60.0 °C(Predicted)
Density: 1.427
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥25.53 mg/mL in EtOH with ultrasonic
form: powder to crystal
pka: 7.86±0.40(Predicted)
color: White to Yellow to Orange
InChI: InChI=1S/C18H17N3O4S/c1-25-15-8-10-16(11-9-15)26(23,24)21-17-3-2-12-19-18(17)20-13-4-6-14(22)7-5-13/h2-12,21-22H,1H3,(H,19,20)
InChIKey: URCVCIZFVQDVPM-UHFFFAOYSA-N
SMILES: C1(S(NC2=CC=CN=C2NC2=CC=C(O)C=C2)(=O)=O)=CC=C(OC)C=C1

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Safety

RTECS: DB2734000
HS Code: 2935.90.9500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3169
Product name: ABT-751
Purity: >98.0%(HPLC)
Packaging: 10mg
Price: $120
Updated: 2025/07/31

TCI Chemical

Product number: A3169
Product name: ABT-751
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $355
Updated: 2025/07/31

Cayman Chemical

Product number: 22935
Product name: ABT-751
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 22935
Product name: ABT-751
Purity: ≥98%
Packaging: 10mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 22935
Product name: ABT-751
Purity: ≥98%
Packaging: 50mg
Price: $553
Updated: 2024/03/01

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E 7010 Chemical Properties,Usage,Production

Description

ABT-751 is a tubulin polymerization inhibitor that binds to the colchicine binding site on β-tubulin (K_i = 3.3 μM). It inhibits tubulin polymerization in a concentration-dependent manner and inhibits growth of 26 human tumor cell lines (IC₅₀s = 0.06-0.08 μg/ml). ABT-751 (100 mg/kg, p.o.) induces tumor regression in NB-1382 neuroblastoma, IRS56 rhabdomyosarcoma, and KT-6 Wilms mouse xenograft models. It also induces tumor endothelial cell retraction and reduces tumor perfusion, but not muscle perfusion, in a 9L rat glioma subcutaneous tumor model.

Uses

ABT-751 (E7010) is a novel, highly orally bioavailable sulfonamides antimitotic compound and tubulin binder. It prevents tubulin aggregation by binding to the colchicine site on β-tubulin, leading to cell cycle arrest in G2/M phase and inducing apoptosis, thus effectively preventing cell division. ABT-751 induces autophagy by inhibiting the AKT/MTOR signaling pathway. ABT-751 showed significant inhibition against various types of cancer cells, including lung, gastric, colon, and breast cancer[1][2][3][4][5][6][7][8].

Definition

ChEBI: N-[2-(4-hydroxyanilino)-3-pyridinyl]-4-methoxybenzenesulfonamide is a sulfonamide.

in vivo

ABT-751 (100 mg/kg/day, Oral gavage (p.o.), 5 days on, 5 days off x2, 21 days) has a significant inhibitory effect in neuroblastoma models and can induce significant reduction or regression of tumor volume in rhabdomyosarcoma and nephroblastoma models. ABT-751 has synergistic effect on Vincristine and Paclitaxel (HY-B0015)^[7].
ABT-751 (100 mg/kg/day, Oral gavage (p.o.), 5 days on, 5 days off x2) has a synergistic effect on Docetaxel (HY-B0011) in prostate, NSCLC, and breast tumor xenografts in mice. Improve the inhibitory effect on tumor^[8].

Animal Model:	xenograft models of neuroblastoma, osteosarcoma, Ewing sarcoma rhabdomyosarcoma, medulloblastoma and eight kidney cancer lines (six Wilms tumors, two rhabdoid)^[7]
Dosage:	100 mg/kg
Administration:	Oral gavage (p.o.)
Result:	Had obvious inhibitory effect in neuroblastoma model. Induced significant reduction or regression of tumor volume in rhabdomyosarcoma and nephroblastoma models. Had a synergistic effect on vincristine or Paclitaxel (HY-B0015).

Animal Model:	PC-3 prostate, Calu-6 NSCLC, and breast MDA-MB-468 tumor xenografts in mice^[7]
Dosage:	75, 100 mg/kg
Administration:	Oral gavage (p.o.)
Result:	It has a synergistic effect with Docetaxel, enhancing the inhibitory effect on tumors.

References

[1] Huang SM et al.,Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling., Nature. 2009 Oct 1;461(7264):614-20. DOI:10.1038/nature08356
[2] Elizabeth Fox et al. A Phase I Study of ABT-751, an Orally Bioavailable Tubulin Inhibitor, Administered Daily for 21 Days Every 28 Days in Pediatric Patients with Solid Tumors Clin Cancer Res February 15, 2008 14; 1111
[3] Aggarwal C, et al. Antiangiogenic agents in the management of non-small cell lung cancer: where do we stand now and where are we headed?,Cancer Biol Ther. 2012 Mar;13(5):247-63. DOI:10.4161/cbt.19594
[4] Silver M, Rusk A, Phillips B, Beck E, Jankowski M, Philibert J, Hahn K, Hershey E, McKeegan E, Bauch J, Krivoshik A, Khanna C.,Evaluation of the oral antimitotic agent (ABT-751) in dogs with lymphoma.,J Vet Intern Med. 2012 Mar-Apr;26(2):349-54. doi: 10.1111/j.1939-1676.2012.00892.x. Epub 2012 Feb 28. DOI:10.1111/j.1939-1676.2012.00892.x
[5] Gaynon PS, Harned TM; for the Therapeutic Advances in Childhood LeukemiaLymphoma (TACL) Consortium. DOI:10.1097/MPH.0b013e3182532446
[6] Morton CL, et al. Evaluation of ABT-751 against childhood cancer models in vivo. Invest New Drugs. 2007;25(4):285-295. DOI:10.1007/s10637-007-9042-y
[7] David Frost, et al. ABT-751, an oral antimitotic, shows additive and synergistic activity with docetaxel in preclinical models. Cancer Res 1 May 2007; 67 (9_Supplement): 1426.
[8] Yoshimatsu K, et al. Mechanism of action of E7010, an orally active sulfonamide antitumor agent: inhibition of mitosis by binding to the colchicine site of tubulin. Cancer Res. 1997;57(15):3208-3213. PMID:9242451

E 7010 Preparation Products And Raw materials

Raw materials

Preparation Products

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E 7010 Suppliers

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View Lastest Price from E 7010 manufacturers

Dideu Industries Group Limited

Product: E 7010 141430-65-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-27

Career Henan Chemical Co

Product: E 7010 141430-65-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-07-11

141430-65-1, E 7010Related Search:

4-Aminodiphenylamine N-Methylbenzamide Vincristine sulfate CYT997 VINBLASTINE NOCODAZOLE Combretastatin A4 phosphate disodium salt Docetaxel

E 7010

N-[2-(4-HYDROXYANILINO)PYRIDIN-3-YL]-4-METHOXYBENZENE-1-SULFONAMIDE

N-[2-[(4-Hydroxyphenyl)amino]-3-pyridyl]-4-methoxybenzenesulfonamide

BenzenesulfonaMide, N-[2-[(4-hydroxyphenyl)aMino]-3-pyridinyl]-4-Methoxy-

ABT-751 (E7010)

N-(2-(4-hydroxyphenylamino)pyridin-3-yl)-4-methoxybenzenesulfonamide

ABT-751 (E

E7010(ABT-751)

ABT-751 (E7010);ABT751; ABT 751

CS-1806

ABT751; ABT 751; E7010; E-7010; E 7010

N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide

CS-505

E 7010 ISO 9001：2015 REACH

ABT-751 ABT751

Microtubule/Tubulin,E 7010,Autophagy,E-7010,Inhibitor,inhibit,ABT 751,ABT751,ABT-751

ABT-751, 10 mM in DMSO

141430-65-1

Inhibitors