Bifonazole

Product Name: Bifonazole
CAS No.: 60628-96-8
Chemical Name: Bifonazole
Synonyms: mycospor;bifonazol;1-[phenyl-(4-phenylphenyl)-methyl]imidazole;Amycor;Bedrid;A-One-L;Azolmen;Bedriol;Bifazol;bayh4502
CBNumber: CB8138176
Molecular Formula: C22H18N2
Formula Weight: 310.4
MOL File: 60628-96-8.mol

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Bifonazole Property

Melting point:: 142℃
Boiling point:: 440.55°C (rough estimate)
Density: 1.1150 (rough estimate)
refractive index: 1.7620 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO
form: powder
pka: 6.55±0.22(Predicted)
color: white to off-white
Merck: 14,1213
LogP: 4.770
CAS DataBase Reference: 60628-96-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 1
RTECS: NI3517000
HS Code: 29332900
Toxicity: LD50 in male mice, rats (mg/kg): 2629, 2854 orally (Schlüter)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B3563
Product name: Bifonazole
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $54.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: B3563
Product name: Bifonazole
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $208
Updated: 2024/03/01

TCI Chemical

Product number: B4173
Product name: Bifonazole
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $34
Updated: 2024/03/01

TCI Chemical

Product number: B4173
Product name: Bifonazole
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $102
Updated: 2024/03/01

Alfa Aesar

Product number: J63253
Product name: Bifonazole, 99%
Packaging: 1g
Price: $46.65
Updated: 2024/03/01

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Bifonazole Chemical Properties,Usage,Production

Description

Bifonazole represents the first topical broad spectrum antimycotic approved for once daily administration. Its in vitro activity appears equivalent to its structural relative clotrimazole, being effective against dermatophytes, other filamentous fungi, dimorphic fungi and yeasts.

Description

Bifonazole is a topically-active imidazole antifungal compound that has broad spectrum activity in vitro against dermatophytes, molds, yeasts, dimorphic fungi, and some Gram-positive bacteria. It is effective in the treatment of experimental dermatophytic and Candida in animals. Bifonazole is also a potent inhibitor of cytochrome P450 aromatase (K_i = 68 nM, IC₅₀ = 270 nM), which catalyzes the biosynthesis of estrogens from androgens. When applied topically in animals, it demonstrates prolonged retention time in skin with minimal percutaneous absorption, thus minimizing its effect on aromatase.

Chemical Properties

White or almost white, crystalline powder.

Originator

Bayer (W. Germany)

Uses

Bifonazole is an imidazole antifungal agent and calmodulin antagonist. It causes a reduction in glycolysis and ATP levels in B16 melanoma cells. Bifonazole is an inhibitor of C14orf1. Bifonazole is an imidazole-based anti-fungal agent with broad spectrum activity against many fungi, molds, yeast and some gram-positive bacteria. Bifonazole inhibits ergosterol biosynthetic protein 28 and Cytochrome P450 2B4.

Uses

antibacterial

Definition

ChEBI: 1-[biphenyl-4-yl(phenyl)methyl]imidazole is a member of the class of imidazoles carrying an alpha-(biphenyl-4-yl)benzyl substituent at position 1. It is a member of imidazoles and a member of biphenyls.

Manufacturing Process

38.8g (0.15 mol) of 4-phenylbenzophenone are dissolved in 200 ml of ethanol and 39 (0.075 mol) of sodium borohydride are added. After heating for 15 hours under reflux, and allowing to cool, the reaction mixture is hydrolyzed with water containing a little hydrochloric acid. The solid thereby produced is purified by recrystallization from ethanol. 36 g (89% of theory) of (biphenyl- 4-yl)-phenyl-carbinol [alternatively named as diphenyl-phenyl carbinol or α- (biphenyl-4-yl)benzylalcohol] of melting point 72°-73°C are obtained.
13.6 g (0.2 mol) of imidazole are dissolved in 150 ml of acetonitrile and 3.5 ml of thionyl chloride are added at 10°C. 13 g (0.05 mol) of (biphenyl-4-yl)- phenyl-carbinol are added to the solution of thionyl-bis-imidazole thus obtained. After standing for 15 hours at room temperature, the solvent is removed by distillation in vacuo. The residue is taken up in chloroform and the solution is washed with water. The organic phase is collected, dried over sodium sulfate and filtered and the solvent is distilled off in vacuo. The oily residue is dissolved in ethyl acetate and freed from insoluble, resinous constituents by filtration. The solvent is again distilled off in vacuo and the residue is purified by recrystallization from acetonitrile, 8.7 g (56% of theory) of (biphenyl-4-yl)-imidazol-1-yl-phenylmethane [alternatively named as diphenyl-imidazolyl-(1)-phenyl-methane or as 1-(α-biphenyl-4- ylbenzyl)imidazole] of melting point 142°C are obtained.

brand name

Mycospor (Bayer).

Therapeutic Function

Antifungal

Bifonazole Preparation Products And Raw materials

Raw materials

Biphenyl 2,2'-Bis(2-chlorophenyl)-4,4',5,5'-tetraphenyl-1,2'-biimidazole

Preparation Products

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Bifonazole Suppliers

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View Lastest Price from Bifonazole manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: bifonazole 60628-96-8
Price: US $0.00/KG
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 100000month/kg
Release date: 2021-03-18

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Bifonazole 60628-96-8
Price: US $45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-12-04

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Bifonazole 60628-96-8
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%-100.5%
Supply Ability: 1000kg
Release date: 2021-07-29

60628-96-8, BifonazoleRelated Search:

Thiophanate-methyl FIREMASTER BP-6 Imidazole Benzyltriethylammonium chloride 5-Chlorovaleric acid Pralmorelin DL-α-Tocopherol Bensulfuron methyl Bifendate trans-Bifenthtin Methylparaben PHENYL VALERATE Methyl acrylate 4-(Diethylamino)salicylaldehyde Diphenolic acid Kresoxim-methyl 2,3,3',4,4',5-HEXACHLOROBIPHENYL 1H-Imidazole, 4-([1,1'-biphenyl]-4-ylphenylmethyl)-

Bifonazole for system suitability

Bifonazole Impurity

bifonazol

Biphenylylbenzylazole

trifonazole

1-[phenyl-(4-phenylphenyl)-methyl]imidazole

1-[P,ALPHA-DIPHENYLBENZYL]IMIDAZOLE

1[4,ALPHA-DIPHENYLBENZYL]-IMIDAZOLE

BIFONAZOLE

1-(p,α-diphenylbenzyl)imidazole

BIFONAZOLE(PATENT-NOSUPPLY)

1-[α-(4-biphenyl)benzyl]-1H-imidazole

1H-Imidazole, 1-([1,1'-biphenyl]-4-ylphenylmethyl)-

Amycor

A-One-L

Azolmen

Bedriol

Bifazol

mycospor

1-((1,1’-biphenyl)-4-ylphenylmethyl)-1h-imidazol

1-((4-biphenylyl)phenylmethyl)-1h-imidazole

1-(alpha-(4-biphenylyl)benzyl)-imidazol

1-(alpha-(4-biphenylyl)benzyl)imidazole

1-[(1,1’-biphenyl)-4-ylphenylmethyl]-1H-Imidazole

bayh4502

Mycosporan

Bedrid

1-[α-(4-Biphenylyl)benzyl]-1H-imidazole

Bifonazole API

Bifonazole, >=98% (HPLC)

1-(Biphenyl-4-yl(Phenyl)Methyl)-1H-Imidazole

Naftifine hydrochloride Solution, 100ppm

Bifonazole &gt

Bifonazole for system suitability CRS

Bifonazole CRS

1-(alpha,4-Diphenylbenzyl)imidazole

Bifonazole USP/EP/BP

BifonazoleQ: What is Bifonazole Q: What is the CAS Number of Bifonazole Q: What is the storage condition of Bifonazole Q: What are the applications of Bifonazole

Bifonazole,NA,Pregabalin

1-([1,1'-Biphenyl]-4-yl(phenyl)methyl)-1H-imidazole

(¨¤)-Bifonazo

Bibenzazole

Bifonazole, 10 mM in DMSO

60628-96-8

API

SARAFLOX