ChemicalBook > CAS DataBase List > 1-Methyl-5-nitro-1H-imidazole-2-methanol

1-Methyl-5-nitro-1H-imidazole-2-methanol

Product Name: 1-Methyl-5-nitro-1H-imidazole-2-methanol
CAS No.: 936-05-0
Chemical Name: 1-Methyl-5-nitro-1H-imidazole-2-methanol
Synonyms: HMMNI;dimetridazole-2-hydroxy;HMMNI Solution, 100ppm;Metronidazole Impurity 33;Dimetridazole-2-hydroxy D3;HMMNI(Dimetridazole-2-hydroxy);Hydroxydimetridazole in methanol;HMMNI (nitroimidazole metabolite);Dimetridazole Metabolite A Standard;(1-Methyl-5-nitroimidazol-2-yl)meth
CBNumber: CB8138277
Molecular Formula: C5H7N3O3
Formula Weight: 157.13
MOL File: 936-05-0.mol

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1-Methyl-5-nitro-1H-imidazole-2-methanol Property

Melting point:: 110-112°C
Boiling point:: 281.76°C (rough estimate)
Density: 1.4890 (rough estimate)
refractive index: 1.6190 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 3 mg/ml; PBS (pH 7.2): 1 mg/ml
pka: 13.31±0.10(Predicted)
form: Solid
color: Light yellow to Yellow to Orange
InChI: InChI=1S/C5H7N3O3/c1-7-4(3-9)6-2-5(7)8(10)11/h2,9H,3H2,1H3
InChIKey: JSAQDPJIVQMBAY-UHFFFAOYSA-N
SMILES: C1(CO)N(C)C([N+]([O-])=O)=CN=1

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Safety

WGK Germany: 3
RTECS: NI6801000
HS Code: 29332900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H341Suspected of causing genetic defects

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 34003
Product name: HMMNI
Purity: VETRANAL?, analytical standard
Packaging: 10MG
Price: $644
Updated: 2025/07/31

TCI Chemical

Product number: H1439
Product name: 2-Hydroxymethyl-1-methyl-5-nitroimidazole
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $104
Updated: 2025/07/31

TCI Chemical

Product number: H1439
Product name: 2-Hydroxymethyl-1-methyl-5-nitroimidazole
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $519
Updated: 2025/07/31

Cayman Chemical

Product number: 16208
Product name: Hydroxy Dimetridazole
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 16208
Product name: Hydroxy Dimetridazole
Purity: ≥98%
Packaging: 10mg
Price: $107
Updated: 2024/03/01

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1-Methyl-5-nitro-1H-imidazole-2-methanol Chemical Properties,Usage,Production

Description

Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity. It was once widely used in the treatment of parasitic infections in poultry, cattle, swine and farmed fish until suspected to be carcinogenic and mutagenic to humans. Hydroxy dimetridazole is a metabolite of dimetridazole that may be useful for identifying this nitroimidazole in various agricultural samples through liquid chromatography–tandem mass spectrometry and other methods.

Chemical Properties

Pale Yellow Solid

Uses

A metabolite of Dimetridazole (D479660).

Synthesis

50-00-0

3034-42-2

936-05-0

In a sealed glass tube, formaldehyde (1 g, 33.54 mmol) and 1-methyl-5-nitro-1H-imidazole (4a) (1 g, 7.8 mmol) were dissolved in DMSO (5 mL). The reaction tube was heated in an oil bath at 140°C for 48 hours. Upon completion of the reaction, the reaction solution was poured into water (5 mL) and extracted with ethyl acetate (3 x 5 mL). The organic phases were combined and dried with anhydrous magnesium sulfate, followed by concentration under reduced pressure to remove the solvent to give the crude product. The crude product was purified by recrystallization via THF/heptane (1:1) mixed solvent to afford the target product 1-methyl-5-nitro-2-hydroxymethylimidazole (5a) (0.76 g, 62% yield) in white powder form. The melting point of the product was 117°C.

References

[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987, p. 2819 - 2828
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 3, p. 1015 - 1018
[3] Journal of Medicinal Chemistry, 2003, vol. 46, # 3, p. 427 - 440
[4] Tetrahedron, 2000, vol. 56, # 4, p. 645 - 657
[5] Patent: WO2014/205414, 2014, A1. Location in patent: Paragraph 0298

1-Methyl-5-nitro-1H-imidazole-2-methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Methyl-5-nitro-1H-imidazole-2-methanol manufacturers

Career Henan Chemical Co

Product: imidazole-2-methanol, 1-methyl-5-nitro- 936-05-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-08

936-05-0, 1-Methyl-5-nitro-1H-imidazole-2-methanolRelated Search:

Methyl acrylate Methanol Kresoxim-methyl Basic Violet 1 Acetonitrile 5-Hydroxymethylfurfural Methylparaben (1H-IMIDAZOL-2-YL)-METHANOL 1-Vinylimidazole 2-Methyl-5-nitroimidazole 1-Methylimidazole Imidazole Methyl nitrotoluene α-[5-(1,1-Dimethylethyl)-2-hydroxyphenyl]-1-methyl-5-nitro-1H-imidazole-2-methanol Fexinidazole 1-Methyl-5-nitro-1H-imidazole-2-methanol carbamate 1-METHYL-5-NITROIMIDAZOLE

2-HYDROXYMETHYL-1-METHYL-5-NITRO-1H-IMIDAZOLE

2-HYDROXYMETHYL-1-METHYL-5-NITRO-IMIDAZOLE

HMMNI

1-methyl-5-nitro-1H-imidazole-2-methanol

1-Methyl-5-Nitro-2-Hydroxymethylimidazole

dimetridazole-2-hydroxy

Dimetridazole-2-hydroxy D3

1-methyl-5-nitroimidazole-2-methanol

(1-Methyl-5-nitro-1H-imidazole-2-yl)methanol

(3-methyl-2-nitro-imidazol-4-yl)methanol

(3-methyl-2-nitroimidazol-4-yl)methanol

HMMNI,2-Hydroxymethyl-1-methyl-5-nitro-1H-imidazole

HMMNI (nitroimidazole metabolite)

1-Methyl-5-nitro-2-iMidazoleMethanol

(1-Methyl-5-nitro-1H-imidazo-2-yl)-methanol

(1-METHYL-5-NITRO-1H-IMIDAZOL-2-YL)-METHANOL

HMMNI Solution, 100ppm

HMMNI solution,1000ppm solution,100ppm

1H-Imidazole-2-methanol, 1-methyl-5-nitro-

imidazole-2-methanol, 1-methyl-5-nitro-

Dimetridazole Metabolite A Standard

(1-Methyl-5-nitroimidazol-2-yl)meth

2-Hydroxymethyl-1-methyl-5-nitroimidazole&gt

Metronidazole Impurity 33

Dimetridazole-2-hydroxy Solution in Methanol, 100μg/mL

Hydroxy DimetridazoleQ: What is Hydroxy Dimetridazole Q: What is the CAS Number of Hydroxy Dimetridazole Q: What is the storage condition of Hydroxy Dimetridazole

HMMNI(Dimetridazole-2-hydroxy)

inhibit,protozoan,Inhibitor,hydroxy,nitroimidazole,infection,Hydroxy Dimetridazole,metabolite,Drug Metabolite,HMMNI

1-methyl-5-nitro-2-hydroxyimidazole

Hydroxydimetridazole in methanol

Hydroxy Dimetridazole, 10 mM in DMSO

Dimetridazole-2-hydroxy 100 μg/mL in Acetone

936-05-0

930-05-0

C5H7N3O3

Heterocycles

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Metabolites & Impurities

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