ChemicalBook > CAS DataBase List > Cyclohexylamine

Cyclohexylamine

Product Name
Cyclohexylamine
CAS No.
108-91-8
Chemical Name
Cyclohexylamine
Synonyms
CHA;Cyclohexylamin;AMINOCYCLOHEXANE;HEXAHYDROANILINE;cyclohexaneamine;CHA-60;cha[qr];AURORA KA-7609;CYCLOHEXYLAMINE;hexahydro-anilin
CBNumber
CB8139274
Molecular Formula
C6H13N
Formula Weight
99.17
MOL File
108-91-8.mol
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Cyclohexylamine Property

Melting point:
-17 °C
Boiling point:
134 °C(lit.)
Density 
0.867 g/mL at 25 °C(lit.)
vapor density 
3.42 (vs air)
vapor pressure 
10 mm Hg ( 22 °C)
refractive index 
n20/D 1.459(lit.)
Flash point:
90 °F
storage temp. 
Store below +30°C.
solubility 
organic solvents: miscible
pka
10.66(at 24℃)
form 
Liquid
color 
Clear
PH
11.5 (100g/l, H2O, 20℃)
Odor
strong fishy odor
explosive limit
1.6-9.4%(V)
Water Solubility 
MISCIBLE
FreezingPoint 
-17.7℃
Sensitive 
Air Sensitive
Merck 
14,2729
BRN 
471175
Exposure limits
TLV-TWA 10 ppm (~40 mg/m3) (ACGIH).
Dielectric constant
5.3(-21℃)
InChIKey
PAFZNILMFXTMIY-UHFFFAOYSA-N
LogP
3.7 at 25℃
CAS DataBase Reference
108-91-8(CAS DataBase Reference)
NIST Chemistry Reference
Cyclohexanamine(108-91-8)
EPA Substance Registry System
Cyclohexylamine (108-91-8)
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Safety

Hazard Codes 
C,T
Risk Statements 
10-21/22-34-62-24-22
Safety Statements 
36/37/39-45-1/2-26
RIDADR 
UN 2357 8/PG 2
OEB
A
OEL
TWA: 10 ppm (40 mg/m3)
WGK Germany 
1
RTECS 
GX0700000
10-34
Autoignition Temperature
559 °F
TSCA 
Yes
HS Code 
2921 30 10
HazardClass 
8
PackingGroup 
II
Hazardous Substances Data
108-91-8(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 0.71 ml/kg (Smyth)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.02885
Product name
Cyclohexylamine
Purity
for synthesis
Packaging
100mL
Price
$44.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.02885
Product name
Cyclohexylamine
Purity
for synthesis
Packaging
1L
Price
$59.3
Updated
2024/03/01
Sigma-Aldrich
Product number
8.02885
Product name
Cyclohexylamine
Purity
for synthesis
Packaging
2.5L
Price
$129
Updated
2024/03/01
Sigma-Aldrich
Product number
240648
Product name
Cyclohexylamine
Purity
ReagentPlus , ≥99.9%
Packaging
5ml
Price
$37.6
Updated
2024/03/01
Sigma-Aldrich
Product number
240648
Product name
Cyclohexylamine
Purity
ReagentPlus , ≥99.9%
Packaging
100ml
Price
$38.5
Updated
2024/03/01
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Cyclohexylamine Chemical Properties,Usage,Production

Description

Cyclohexylamine is a colorless to yellow liquid (amines, primary aromatic). It has an unpleasant fishyodor. Molecular weight=99.20; Specific gravity=0.87;Boiling point=134.4℃; Freezing/Melting point 52 -17.7℃; Vapor pressure=11 mmHg at 20℃; Flashpoint=31℃; Autoignition temperature=293℃. Explosivelimits: LEL=1.5%; UEL=9.4%. Hazard Identification(based on NFPA-704 M Rating System): Health 3,Flammability 3, Reactivity 0. Soluble in water.

Chemical Properties

Cyclohexylamine is a colorless to yellow liquid (amines, primary aromatic). It has an unpleasant fishy odor. Flammable. It is infinitely miscible with water and conventional organic solvents. With water it forms an azeotrope that contains 44.2 % cyclohexylamine and boils at 96.4℃. Cyclohexylamine can be volatilized with water vapor. It can absorb carbon dioxide in the air and form a white crystalline carbonate. Aqueous solution is alkaline. 0.01% concentration of aqueous solution pH = 10.5. Its vapor and air to form an explosive mixture.

Uses

In organic synthesis, manufacture of insecticides, plasticizers, corrosion inhibitors, rubber chemicals, dyestuffs, emulsifying agents, dry-cleaning soaps, acid gas absorbents.
Cyclohexylamine is used primarily as corrosion inhibitor and vulcanization accelerator. Alone or mixed with other compounds, it has an anticorrosive action, for example, when used as an additive in heating oil or in the operation of steam boilers.
Cyclohexylamine functions as a hardener for epoxy resins and as a catalyst for polyurethanes. Sodium cyclohexylsulfamate and calcium cyclohexylsulfamate (cyclamates) are important artificial sweeteners. In polyamide polymerizations, cyclohexylamine is employed as chain terminator to control the molecular mass.

Uses

Cyclohexylamine is used in the manufacture of a number of products, including plasticizers, drycleaning soaps, insecticides, and emulsifying agents. It is also used as a corrosion inhibitor and in organic synthesis.

Definition

ChEBI: Cyclohexylamine is a primary aliphatic amine consisting of cyclohexane carrying an amino substituent. It has a role as a human xenobiotic metabolite and a mouse metabolite. It is a conjugate base of a cyclohexylammonium.

Production Methods

Cyclohexylamine is produced by the reaction of ammonia and cyclohexanol at elevated temperature and pressure in the presence of a silica-alumina catalyst (SRI 1985). It is also prepared by a similar process of catalytic hydrogenation of aniline at elevated temperature and pressure. Fractionation of the product of this reaction yields CHA, aniline, and a high-boiling residue containing n-phenylcyclohexylamine and dicyclohexylamine (Carswell and Morrill 1937). In 1982, U.S. production was 4.54 metric tons and 739.3 metric tons were imported into the U.S. (SRI 1985).

Reactions

Cyclohexylamine reacts with chlorine to form N,N-dichlorocyclohexylamine. N-Cyclohexylidenecyclohexylamine reacts with chloramine to give 1-cyclohexyl-3,3-pentamethylenediaziridine, which can be hydrolyzed to give cyclohexylhydrazine [46]. Cyclohexylamine and formaldehyde together react with peracetic acid to give 2-cyclohexyloxaziridine. In addition to using alkyl halides, alkyl sulfates, or alkyl phosphates, cyclohexylamine can be alkylated with an alcohol in the presence of a catalyst, such as aluminum oxide, copper, nickel, cobalt, or platinum, or by the Leuckart – Wallach method.

General Description

Cyclohexylamine appears as a clear colorless to yellow liquid with an odor of ammonia. Flash point 90 °F. Irritates the eyes and respiratory system. Skin contact may cause burns. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.

Air & Water Reactions

Highly flammable. Sensitive to air and light. Soluble in water.

Reactivity Profile

Cyclohexylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

Cyclohexylamine is a severe irritant to theeyes, skin, and respiratory passage. Skincontact can produce burns and sensitization;contact of the pure liquid or its concentratedsolutions with the eyes may cause loss ofvision.
The acute oral and dermal toxicity ofcyclohexylamine was moderate in test sub jects. The toxic effects include nausea, vom iting, and degenerative changes in the brain,liver, and kidney. Inhalation of its vaporsat high concentrations may cause a narcoticeffect.
LD50 value, oral (rats): 156 mg/kg
LD50 value, skin (rabbits): 277 mg/klg
Cyclohexylamine may be mutagenic, thetest for which has so far given inconclusiveresults. Administration of this compoundin animals produced a reproductive effect,including embryotoxicity and a reductionin male fertility. Intraperitoneal injectionof the amine in rats caused a dose dependent increase in chromosomal breaks.Roberts and coworkers (1989) studied themetabolism and testicular toxicity of cyclohexylamine (a metabolite of cyclamate)in rats and mice. Chronic dietary administration of 400 mg/kg/day for 13 weeksshowed decrease in organ weigh, histological changes, and testicular atrophy in boththe Wistar and dark agouti DA rats, but to awidely varying extent, while mice exhibitedno evidence of testicular damage.
There is no evidence of carcinogenicityin animals or humans caused by cyclohexy lamine.

Fire Hazard

When heated to decomposition, Cyclohexylamine emits highly toxic fumes. Vapor may travel a considerable distance to source of ignition and flash back. Toxic oxides of nitrogen are produced during combustion. Nitric acid; reacts vigorously with oxiding materials. Stable, avoid physical damage, storage with oxidizing material.

Industrial uses

The primary use of cyclohexylamine is as a corrosion inhibitor in boiler water treatment and in oil field applications (HSDB 1989). It is also a chemical intermediate for rubber processing chemicals, dyes (acid blue 62, former use), cyclamate artificial sweeteners and herbicides and a processing agent for nylon fiber production (SRI 1985). Windholz et al (1983) reports its use in the manufacture of insecticides, plasticizers, emulsifying agents, dry-cleaning soaps, and acid gas absorbents.

Safety Profile

A poison by ingestion, skin contact, and intraperitoneal routes. Experimental teratogenic and reproductive effects. A severe human skin irritant. Can cause dermatitis and convulsions. Human mutation data reported. Questionable carcinogen. Flammable liquid. Dangerous fire hazard when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.

Synthesis

Prepared by catalytic hydrogenation of aniline at elevated temp and pressures. Fractionation of crude reaction product yields cyclohexylamine, unchanged aniline, and high-boiling residue containing n-phenylcyclohexylamine (cyclohexylaniline) and dicyclohexylamine.

Potential Exposure

CHA is used in making dyes, chemi- cals, dry cleaning chemicals; insecticides, plasticizers, rub- ber chemicals; and as a chemical intermediate in the production of cyclamate sweeteners. Used in water treat- ment and as a boiler feedwater additive. It is also used in rubber production to retard degradation.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin,remove contaminated clothing and wash immediately withsoap and water. Seek medical attention immediately. If thischemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart actionhas stopped. Transfer promptly to a medical facility. Whenthis chemical has been swallowed, get medical attention. Ifvictim is conscious, administer water or milk. Do not inducevomiting. Medical observation is recommended for 24-48 hafter breathing overexposure, as pulmonary edema may bedelayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a corticosteroidspray.
Note to physician: Treat for methemoglobinemia.
Spectrophotometry may be required for precise determination of levels of methemoglobinemia in urine

Carcinogenicity

According to the International Agency for Research of Cancer (IARC) working group, there is no evidence that cyclohexylamine is teratogenic or carcinogenic.

Metabolism

Generally, cyclohexylamine is readily absorbed and rapidly excreted from the body. After administration to rats, cyclohexylamine appears in body tissues with the highest concentrations in the lungs, spleen, liver, adrenals, heart, gastrointes- tinal tract and kidneys (Estep and Wiegand 1967 as reported by Bopp et al 1986).
After oral administration (0.2 g/kg) to rabbits, cyclohexylamine gave rise to unchanged cyclohexylamine and 7V-hydroxycyclohexylamine in the urine (Elliott et al 1968). When [14C]-labelled cyclohexylamine was administered, 68% of the radioactivity was recovered in the urine after 60 h. A small amount (0.5%) was eliminated in the breath and 45% of the administered dose was shown to be excreted in the urine as unconjugated cyclohexylamine, 0.2% as JV-hydroxycyclohexylamine in conjugated form, and 2.5% as cyclohexanone oxime. The authors postulated the latter metabolite to be an artifact formed from the glucuronide of TV-hydroxy cyclohexylamine during the hydrolysis procedure.
In contrast to rabbits, man, as well as rats and guinea pigs, excrete 90% or more of a dose of [14C]-labelled cyclohexylamine unchanged in the urine (Renwick and Williams 1972). Small amounts of radioactivity were found in the feces, 1% or less in man, rat and rabbit, and 4-7% in the guinea pig. Only 4-5% of the dose was metabolized in 24 h in the rat and guinea pig and 1-2% in man. The metabolites identified indicated that in rats, the metabolism of cyclohexylamine was mainly through hydroxylation of the cyclohexane ring, in man by deamination and in guinea pigs and rabbits by ring hydroxylation and deamination. The metabolites to cyclohexylamine were excreted in both free and conjugated forms.

storage

Cyclohexylamine can be stored and shipped in iron tanks. Nonferrous metals, particularly copper-containing materials, are attacked and are therefore unsuitable. The amine discolors on contact with air and therefore must be kept under nitrogen.

Shipping

UN2357 Cyclohexylamine, Hazard class: 8; Labels: 8-Corrosive material, 3-Flammable liquid.

Purification Methods

Dry the amine with CaCl2 or LiAlH4, then distil it from BaO, KOH or Na, under N2. Also purify it by conversion to the hydrochloride (which is crystallised several times from water), then liberation of the amine with alkali and fractional distillation under N2. The hydrochloride has m 205-207o (dioxane/EtOH). [Lycan et al. Org Synth Coll Vol II 319 1943, Beilstein 12 III 10, 12 IV 8.]

Incompatibilities

May form explosive mixture with air. Cyclohexylamine is a strong base: it reacts violently with acid. Contact with strong oxidizers may cause fire and explosion hazard. Incompatible with organic anhydrides; isocyanates, vinyl acetate; acrylates, substituted allyls; alkylene oxides; epichlorohydrin, ketones, aldehydes, alco- hols, glycols, phenols, cresols, caprolactum solution; lead. Corrosive to copper alloys, zinc, or galvanized steel.

Waste Disposal

Incineration; incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions.

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View Lastest Price from Cyclohexylamine manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Cyclohexylamine 108-91-8
Price
US $30.00-10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2023-08-08
Hebei Weibang Biotechnology Co., Ltd
Product
Cyclohexylamine 108-91-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-24
Hebei Chuanghai Biotechnology Co,.LTD
Product
Cyclohexylamine 108-91-8
Price
US $10.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-09

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