5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE

Product Name: 5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE
CAS No.: 757978-18-0
Chemical Name: 5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE
Synonyms: Zinc04352700;5-Bromo-3-iodo-7-azaindole;5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE;3-Bromo-5-iodo-7H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-iodo-;5-Bromo-3-iodo-1H-pyrrolo(2,3-b)pyridine 97%
CBNumber: CB8139289
Molecular Formula: C7H4BrIN2
Formula Weight: 322.93
MOL File: 757978-18-0.mol

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5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE Property

Melting point:: 234-239 °C
Boiling point:: 324℃
Density: 2.52
Flash point:: 150℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: solid
pka: 11.42±0.40(Predicted)
color: Off-white to light yellow
Sensitive: Light Sensitive
InChI: InChI=1S/C7H4BrIN2/c8-4-1-5-6(9)3-11-7(5)10-2-4/h1-3H,(H,10,11)
InChIKey: GIPGJYARDOQGDJ-UHFFFAOYSA-N
SMILES: C12NC=C(I)C1=CC(Br)=CN=2

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 702307
Product name: 5-Bromo-3-iodo-7-azaindole
Purity: 97%
Packaging: 1g
Price: $72.93
Updated: 2025/07/31

TCI Chemical

Product number: B6412
Product name: 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine
Packaging: 1G
Price: $90
Updated: 2025/07/31

TCI Chemical

Product number: B6412
Product name: 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine
Packaging: 5G
Price: $270
Updated: 2025/07/31

TRC

Product number: B694575
Product name: 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 020019
Product name: 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine
Purity: 95%
Packaging: 250mg
Price: $258
Updated: 2021/12/16

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5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE Chemical Properties,Usage,Production

Uses

5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine is a useful intermediate for organic synthesis.

Synthesis

183208-35-7

757978-18-0

General procedure for the synthesis of 5-bromo-3-iodo-7-azaindole from 5-bromo-7-azaindole: Preparation of 5-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine (Intermediate A) [0442]. 5-Bromo-1H-pyrrolo[2,3-b]pyridine (10 g, 50.76 mmol) was dissolved in 500 mL of acetone with stirring, followed by the addition of N-iodosuccinimide. The reaction mixture was stirred at room temperature for 20 min. Upon completion of the reaction, the product was pulverized, the white solid was collected by filtration and washed with 100 mL of acetone. The resulting solid was dried under vacuum to afford 5-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine (16.34 g, 100% yield) as a light yellow powder.1H NMR (DMSO-d6, 300 MHz) δ 8.51 (d, J = 2.1 Hz, 1H), 8.22 (s, 1H), 8.02 (d, J = 1.2 Hz, 1H), 8.00 (d, J = 5.1 Hz, 2H), 7.44 (dd, J = 8.7 Hz, 0.6 Hz, 2H), 2.35 (s, 3H); MS ESI (m/z): 322/324 [M + H]+, calculated value 322.

References

[1] Patent: WO2011/149950, 2011, A2. Location in patent: Page/Page column 162
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 23, p. 9569 - 9585
[3] Patent: WO2014/85795, 2014, A1. Location in patent: Paragraph 0400
[4] Patent: US2015/307492, 2015, A1. Location in patent: Paragraph 0120-0125
[5] Patent: WO2016/26078, 2016, A1. Location in patent: Paragraph 076

5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE Suppliers

China 169 Germany 1 India 4 Switzerland 1 United Kingdom 2 United States 14 Global 191

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View Lastest Price from 5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE manufacturers

Career Henan Chemical Co

Product: 5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE 757978-18-0
Price: US $1.00/g
Min. Order: 1g
Purity: 95%~99%
Supply Ability: per week 100kg
Release date: 2019-09-10

757978-18-0, 5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINERelated Search:

5-Bromo-3-chloro-1H-pyrrolo[2,3-b]pyridine 7-Azaindole 3-Iodo-7-azaindole 4-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE 3-BROMO-5-IODO-1H-PYRROLO[2,3-B]PYRIDINE 6-BROMO-3-IODO-1H-PYRROLO[3,2-B]PYRIDINE 5-BROMO-3-IODO-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLICACIDTERT-BUTYLESTER 5-BROMO-3-IODO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE 1-BENZENESULFONYL-5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE 5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE 5-BROMO-3-IODO-6-METHYL-7-AZAINDOLE

5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE

5-Bromo-3-iodo-7-azaindole

Zinc04352700

1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-iodo-

5-Bromo-3-iodo-1H-pyrrolo(2,3-b)pyridine 97%

3-Bromo-5-iodo-7H-pyrrolo[2,3-b]pyridine

757978-18-0

Iodide

Heterocycle-Pyridine series