ChemicalBook > CAS DataBase List > Potassium bis(trimethylsilyl)amide

Potassium bis(trimethylsilyl)amide

Product Name
Potassium bis(trimethylsilyl)amide
CAS No.
40949-94-8
Chemical Name
Potassium bis(trimethylsilyl)amide
Synonyms
KHMDS;POTASSIUM HEXAMETHYLDISILAZIDE;HEXAMETHYLDISILAZANE POTASSIUM SALT;HMDS K;KHMDS 0.7M;PotassiumHMDS;Potassium bis(trimet;Potassium bis(trimethyL;potassiumhexamethyldisil;POTASSIUM HEXAMETHYLDISLAZANE
CBNumber
CB8139300
Molecular Formula
C6H18KNSi2
Formula Weight
199.48
MOL File
40949-94-8.mol
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Potassium bis(trimethylsilyl)amide Property

Melting point:
194-195°C
Boiling point:
111 °C
Density 
0.877 g/mL at 25 °C
vapor density 
3.2 (vs air)
vapor pressure 
54 mm Hg ( 25 °C)
refractive index 
1.4920
Flash point:
45 °F
storage temp. 
Refrigerator
solubility 
Miscible with terahydrofuran, ether, benzene and toluene.
form 
Liquid
Specific Gravity
0.877
color 
clear to slightly hazy yellow
Water Solubility 
Reacts with water.
Hydrolytic Sensitivity
8: reacts rapidly with moisture, water, protic solvents
Sensitive 
Moisture Sensitive
BRN 
4006754
CAS DataBase Reference
40949-94-8(CAS DataBase Reference)
EPA Substance Registry System
Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, potassium salt (1:1) (40949-94-8)
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Safety

Hazard Codes 
C,F,Xn
Risk Statements 
14-34-67-65-63-48/20-11-40-36/37/38-19-37
Safety Statements 
26-36/37/39-45-62-43-46-16-36/37
RIDADR 
UN 3263 8/PG 3
WGK Germany 
3
F 
1-3-10
TSCA 
No
HazardClass 
3
PackingGroup 
II
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
277304
Product name
Potassium bis(trimethylsilyl)amide solution
Purity
0.5 M in toluene
Packaging
4x25ml
Price
$91.6
Updated
2024/03/01
Sigma-Aldrich
Product number
277304
Product name
Potassium bis(trimethylsilyl)amide solution
Purity
0.5 M in toluene
Packaging
2l
Price
$880
Updated
2024/03/01
TCI Chemical
Product number
H0893
Product name
Potassium Bis(trimethylsilyl)amide (11% in Toluene, ca. 0.5mol/L)
Packaging
100mL
Price
$89
Updated
2021/12/16
TCI Chemical
Product number
H0893
Product name
Potassium Bis(trimethylsilyl)amide (11% in Toluene, ca. 0.5mol/L)
Packaging
500mL
Price
$268
Updated
2021/12/16
Sigma-Aldrich
Product number
775061
Product name
Potassium bis(trimethylsilyl)amide solution
Purity
1.0 M in 2-methyltetrahydrofuran
Packaging
4x25ml
Price
$327
Updated
2024/03/01
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Potassium bis(trimethylsilyl)amide Chemical Properties,Usage,Production

Chemical Properties

Colorless to amber solution

Uses

Potassium Hexamethyldisilazide is widely used as a Sterically Hindered Base for Enolate Generation in Selective Formation of Linear Conjugated Dienolates and Alkyl (Z)-3-Alkenoates.

Uses

Potassium Bis(trimethylsilyl)amide (1M in THF) is used in the preparation of 5-azacytidine, an antineoplastic drug. Also applied in the preparation of β3-AR agonists used in anti-stress formulations. It is also used as a reagent in the preparation of lanthanide complexes employed in selective cyclization reactions.

Uses

Potassium bis(trimethylsilyl)amide is a strong base used in the alkylation carbonyl compounds.1

Preparation

Potassium Hexamethyldisilazide is prepared and isolated by the procedure of Wannagat and Niederpruem. A more convenient in situ generation from potassium hydride and hexamethyldisilane is described by Brown.

General Description

This product, 1.0 M in 2-methyltetrahydrofuran aligns with "Safer Solvents and Auxiliaries", "Use of Renewable Feedstocks" and "Inherently Safer Chemistry for Accident Prevention".

Potassium bis(trimethylsilyl)amide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Potassium bis(trimethylsilyl)amide manufacturers

airuikechemical co., ltd.
Product
potassium bis(trimethylsilyl)amide 40949-94-8
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
Potassium bis(trimethylsilyl)amide 40949-94-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
Potassium hexamethyldisilazide 40949-94-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-09

40949-94-8, Potassium bis(trimethylsilyl)amideRelated Search:

Dichlorodimethylsilane TRIMETHYLSILANE Potassium sorbate tert-Butyldimethylsilyl chloride Fomesafen RINK AMIDE RESIN Azidotrimethylsilane Lithium bis(trimethylsilyl)amide Hexamethyldisilazane Rink Amide Linker N-(Trimethylsilyl)acetamide Methyltrichlorosilane Potassium iodide Potassium chloride Potassium Citrate Hexamethyldisilane Tris(hydroxymethyl)aminomethane Methyltriethoxysilane

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