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escin IIa

Product Name: escin IIa
CAS No.: 158732-55-9
Chemical Name: escin IIa
Synonyms: AESCIN IIA;EscinIC;escin IIa;82XHO27XQ8;b-D-Glucopyranosiduronic acid, (3b,4b,16a,21b,22a)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-ylO-b-D-glucopyranosyl-(14)-O-[b-D-xylopyranosyl-(12)]-;β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→4)-O-[β-D-xylopyranosyl-(1→2)]-
CBNumber: CB81399174
Molecular Formula: C54H84O23
Formula Weight: 1101.24
MOL File: 158732-55-9.mol

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escin IIa Property

Boiling point:: 1111.9±65.0 °C(Predicted)
Density: 1.45±0.1 g/cm3 (20 ºC 760 Torr)
pka: 2.63±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: N2139
Product name: AescinIIA
Packaging: 20mg
Price: $200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0000483
Product name: ESCIN IIA
Purity: 95.00%
Packaging: 5MG
Price: $499.84
Updated: 2021/12/16

AvaChem

Product number: 2396
Product name: Escin IIa
Packaging: 5mg
Price: $390
Updated: 2021/12/16

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escin IIa Chemical Properties,Usage,Production

Uses

Escin IIa, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals. Escin IIa has gastroprotections on ethanol-induced gastric mucosal lesions in rats[1][2].

in vivo

Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibits the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest^[1].
Escin IIa (10-50 mg/kg;p.o.;) potently inhibits ethanol-induced gastric mucosal lesions^[2].

Animal Model:	Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats)^[1]
Dosage:	10-50 mg/kg
Administration:	p.o.
Result:	Showed a potent protective effect against ethanol-induced gastric lesions in rats.

References

[1] Matsuda H, et al. Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals. Biol Pharm Bull. 1997;20(10):1092-1095. DOI:10.1248/bpb.20.1092
[2] Matsuda H, et al. Gastroprotections of escins Ia, Ib, IIa, and IIb on ethanol-induced gastric mucosal lesions in rats. Eur J Pharmacol. 1999;373(1):63-70. DOI:10.1016/s0014-2999(99)00249-6

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View Lastest Price from escin IIa manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Aescin IIA 158732-55-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-23

Career Henan Chemical Co

Product: 82XHO27XQ8 158732-55-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 1000kg
Release date: 2018-12-25

158732-55-9, escin IIaRelated Search:

AESCIN IA(SH) ESCIN IIB AESCIN IB(SH) Isoescin IB (3beta,4beta,16alpha,21beta,22alpha)-28-(Acetyloxy)-16,22,23-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-beta-D-glucopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-4)]-beta-D-glucopyranosiduronic acid Escin Ie Protoaescigenin Escin, monosodium salt Escin

escin IIa

82XHO27XQ8

AESCIN IIA

b-D-Glucopyranosiduronic acid, (3b,4b,16a,21b,22a)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-ylO-b-D-glucopyranosyl-(14)-O-[b-D-xylopyranosyl-(12)]-

β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→4)-O-[β-D-xylopyranosyl-(1→2)]-

EscinIC

158732-55-9

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract