2,3-Dichlorobenzoyl cyanide
- Product Name
- 2,3-Dichlorobenzoyl cyanide
- CAS No.
- 77668-42-9
- Chemical Name
- 2,3-Dichlorobenzoyl cyanide
- Synonyms
- 2,3-Dichlorobenzoylc;Lamotrigine Impurity 5;Lamotrigine Impurity 10;Lamotrigine Impurity 25;2,3-DichloroBenzoylNitrile;2,3-dichlorobenozyl cyanide;2,3-DICHLOROBENZOYL CYANIDE;Dichlorobenzoyl Lamotrigine;2,3-Dichlorobenzoyl cyanide, 98%;(2,3-dichlorophenyl)oxoacetonitrile
- CBNumber
- CB8147167
- Molecular Formula
- C8H3Cl2NO
- Formula Weight
- 200.02
- MOL File
- 77668-42-9.mol
2,3-Dichlorobenzoyl cyanide Property
- Melting point:
- 52-53 °C(Solv: ligroine (8032-32-4))
- Boiling point:
- 309°C
- Density
- 1.446
- Flash point:
- 141°C
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- color
- Cream
- InChI
- InChI=1S/C8H3Cl2NO/c9-6-3-1-2-5(8(6)10)7(12)4-11/h1-3H
- InChIKey
- FIBBFBXFASKAON-UHFFFAOYSA-N
- SMILES
- C1(C(=O)C#N)=CC=CC(Cl)=C1Cl
- CAS DataBase Reference
- 77668-42-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- RIDADR
- UN3439
- Hazard Note
- Irritant
- HazardClass
- 6.1
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D432250
- Product name
- 2,3-DichlorobenzoylNitrile
- Packaging
- 50g
- Price
- $1185
- Updated
- 2021/12/16
- Product number
- 56831
- Product name
- 2,3-DichlorobenzoylNitrile
- Packaging
- 100g
- Price
- $2450
- Updated
- 2021/12/16
- Product number
- 084725
- Product name
- 2,3-Dichlorobenzoyl cyanide
- Purity
- 97%
- Packaging
- 500g
- Price
- $405
- Updated
- 2021/12/16
- Product number
- FD33387
- Product name
- 2,3-Dichlorobenzoyl cyanide
- Packaging
- 100g
- Price
- $480
- Updated
- 2021/12/16
- Product number
- J50793
- Product name
- 2,3-Dichlorobenzoylcyanide
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
2,3-Dichlorobenzoyl cyanide Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
2,3-Dichlorobenzoyl cyanide is an impurity of Lamotrigine (L173250), an anticonvulsant that is used in the treatment of bipolar and depression.
Synthesis
2905-60-4
143-33-9
77668-42-9
1. Synthesis of 2,3-dichlorobenzoyl cyanide 2,3-Dichlorobenzoyl chloride (20.0 g, 100 mmol) and cuprous iodide (I) (0.90 g, 4.7 mmol) were suspended in acetonitrile (50 mL) and stirred at room temperature until a yellow homogeneous solution was formed. Solid sodium cyanide (5.15 g, 110 mmol) was added slowly with a controlled addition time of 5-8 hours. After addition, stirring of the reaction mixture was continued for 1 h. The reaction progress was monitored by HPLC. The resulting inorganic salt (mainly NaCl) was removed by filtration and the filter cake was washed with acetonitrile (15 mL). Acetonitrile was removed by distillation under reduced pressure (~150 mbar). Sodium metabisulfite (Na2S2O3, 0-4 g, 3 mmol) was added to remove trace iodine. Finally, the product was purified by vacuum distillation (jacket temperature 140°C, boiling point 115°C/2 mbar) to give 2,3-dichlorobenzoyl cyanide in >80% yield and 100% purity (as determined by analytical HPLC) with a melting point of 60°C.
References
[1] Patent: WO2008/19798, 2008, A1. Location in patent: Page/Page column 12
2,3-Dichlorobenzoyl cyanide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-Dichlorobenzoyl cyanide manufacturers
- Product
- 2,3-Dichlorobenzoyl cyanide 77668-42-9
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 1 ton
- Release date
- 2025-08-22
- Product
- 2,3-Dichlorobenzoyl cyanide 77668-42-9
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-25
- Product
- 2,3-Dichlorobenzoyl cyanide 77668-42-9
- Price
- US $980.00-750.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-15