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3-Amino-5-cyclobutyl-1H-pyrazole

Product Name
3-Amino-5-cyclobutyl-1H-pyrazole
CAS No.
326827-21-8
Chemical Name
3-Amino-5-cyclobutyl-1H-pyrazole
Synonyms
5-Amino-3-cyclobutylpyrazole;3-AMino-5-cyclobutyl-1H-p...;5-Cyclobutyl-1H-pyrazol-3-aMine;3-AMino-5-cyclobutyl-2H-pyrazole;3-Amino-5-cyclobutyl-1H-pyrazole;1H-Pyrazol-3-amine, 5-cyclobutyl-
CBNumber
CB81475997
Molecular Formula
C7H11N3
Formula Weight
137.18
MOL File
326827-21-8.mol
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3-Amino-5-cyclobutyl-1H-pyrazole Property

Boiling point:
368.1±30.0 °C(Predicted)
Density 
1.258±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
15.68±0.10(Predicted)
Appearance
White to light yellow Solid-liquid mixture
Water Solubility 
Slightly soluble in water.
Sensitive 
Air Sensitive
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Safety

HazardClass 
IRRITANT
HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A578168
Product name
3-Amino-5-cyclobutyl-1H-pyrazole
Packaging
500mg
Price
$220
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-1-C1
Product name
3-Amino-5-cyclobutyl-1H-pyrazole
Packaging
1g
Price
$225
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-1-C1
Product name
3-Amino-5-cyclobutyl-1H-pyrazole
Packaging
250mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
3669AB
Product name
3-Amino-5-cyclobutyl-1H-pyrazole
Packaging
1g
Price
$238
Updated
2021/12/16
Matrix Scientific
Product number
057832
Product name
3-Cyclobutyl-1H-pyrazol-5-amine
Purity
95%
Packaging
1g
Price
$285
Updated
2021/12/16
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3-Amino-5-cyclobutyl-1H-pyrazole Chemical Properties,Usage,Production

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

118431-89-3

326827-21-8

General procedure for the synthesis of 3-amino-5-cyclobutyl-1H-pyrazole from 3-cyclobutyl-3-oxopropanenitrile: Crude 3-cyclobutyl-3-oxopropanenitrile (10.0 g, 81.3 mmol) was dissolved in ethanol (300 mL), followed by addition of hydrazine in equimolar amounts. The reaction mixture was heated to 75 °C in an oil bath for 14 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The concentrated oily product was dissolved in ethyl acetate and washed with saturated aqueous sodium bicarbonate. After separating the organic and aqueous layers, the aqueous layer was then extracted with ethyl acetate. All organic layers were combined, dried with anhydrous magnesium sulfate, filtered to remove the desiccant and the filtrate was concentrated under reduced pressure. The crude product was purified by rapid column chromatography on a Biotage 75S MPLC system (Dynax Corp., Charlottesville, VA), eluting sequentially with pure ethyl acetate (2 L) and 10% methanol/dichloromethane (2 L). The fraction containing the target product was collected and concentrated under reduced pressure to afford 3-amino-5-cyclobutyl-1H-pyrazole (10.0 g, 91% yield) as a brown oil. Its structure was confirmed by 400 MHz 1H NMR (CDCl3) and LRMS (APCI+): 1H NMR δ 5.47 (s, 1H), 5.25 (bs, 3H), 3.40 (dddd, J = 8.3,8.3,8.3,8.3, 8.3Hz, 1H), 2.34-2.27 (m, 2H), 2.16-1.88 (m. 4H); LRMS m/z (APCI+) 138 (M + 1).

References

[1] Patent: US2004/266815, 2004, A1. Location in patent: Page 11-12
[2] Bioorganic and Medicinal Chemistry Letters, 2018,

3-Amino-5-cyclobutyl-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Amino-5-cyclobutyl-1H-pyrazole Suppliers

China 73 Germany 1 India 2 Ukraine 1 United Kingdom 2 United States 9 Global 88
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
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View Lastest Price from 3-Amino-5-cyclobutyl-1H-pyrazole manufacturers

Career Henan Chemical Co
Product
3-Amino-5-cyclobutyl-1H-pyrazole 326827-21-8
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2020-01-12

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