3-Amino-5-cyclobutyl-1H-pyrazole

Product Name: 3-Amino-5-cyclobutyl-1H-pyrazole
CAS No.: 326827-21-8
Chemical Name: 3-Amino-5-cyclobutyl-1H-pyrazole
Synonyms: 5-Amino-3-cyclobutylpyrazole;3-AMino-5-cyclobutyl-1H-p...;5-Cyclobutyl-1H-pyrazol-3-aMine;3-AMino-5-cyclobutyl-2H-pyrazole;3-Amino-5-cyclobutyl-1H-pyrazole;1H-Pyrazol-3-amine, 5-cyclobutyl-
CBNumber: CB81475997
Molecular Formula: C7H11N3
Formula Weight: 137.18
MOL File: 326827-21-8.mol

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3-Amino-5-cyclobutyl-1H-pyrazole Property

Boiling point:: 368.1±30.0 °C(Predicted)
Density: 1.258±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 15.68±0.10(Predicted)
Appearance: White to light yellow Solid-liquid mixture
Water Solubility: Slightly soluble in water.
Sensitive: Air Sensitive

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Safety

HazardClass: IRRITANT
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A578168
Product name: 3-Amino-5-cyclobutyl-1H-pyrazole
Packaging: 500mg
Price: $220
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-1-C1
Product name: 3-Amino-5-cyclobutyl-1H-pyrazole
Packaging: 1g
Price: $225
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-1-C1
Product name: 3-Amino-5-cyclobutyl-1H-pyrazole
Packaging: 250mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: 3669AB
Product name: 3-Amino-5-cyclobutyl-1H-pyrazole
Packaging: 1g
Price: $238
Updated: 2021/12/16

Matrix Scientific

Product number: 057832
Product name: 3-Cyclobutyl-1H-pyrazol-5-amine
Purity: 95%
Packaging: 1g
Price: $285
Updated: 2021/12/16

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3-Amino-5-cyclobutyl-1H-pyrazole Chemical Properties,Usage,Production

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

118431-89-3

326827-21-8

General procedure for the synthesis of 3-amino-5-cyclobutyl-1H-pyrazole from 3-cyclobutyl-3-oxopropanenitrile: Crude 3-cyclobutyl-3-oxopropanenitrile (10.0 g, 81.3 mmol) was dissolved in ethanol (300 mL), followed by addition of hydrazine in equimolar amounts. The reaction mixture was heated to 75 °C in an oil bath for 14 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The concentrated oily product was dissolved in ethyl acetate and washed with saturated aqueous sodium bicarbonate. After separating the organic and aqueous layers, the aqueous layer was then extracted with ethyl acetate. All organic layers were combined, dried with anhydrous magnesium sulfate, filtered to remove the desiccant and the filtrate was concentrated under reduced pressure. The crude product was purified by rapid column chromatography on a Biotage 75S MPLC system (Dynax Corp., Charlottesville, VA), eluting sequentially with pure ethyl acetate (2 L) and 10% methanol/dichloromethane (2 L). The fraction containing the target product was collected and concentrated under reduced pressure to afford 3-amino-5-cyclobutyl-1H-pyrazole (10.0 g, 91% yield) as a brown oil. Its structure was confirmed by 400 MHz 1H NMR (CDCl3) and LRMS (APCI+): 1H NMR δ 5.47 (s, 1H), 5.25 (bs, 3H), 3.40 (dddd, J = 8.3,8.3,8.3,8.3, 8.3Hz, 1H), 2.34-2.27 (m, 2H), 2.16-1.88 (m. 4H); LRMS m/z (APCI+) 138 (M + 1).

References

[1] Patent: US2004/266815, 2004, A1. Location in patent: Page 11-12
[2] Bioorganic and Medicinal Chemistry Letters, 2018,

3-Amino-5-cyclobutyl-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Amino-5-cyclobutyl-1H-pyrazole Suppliers

China 73 Germany 1 India 2 Ukraine 1 United Kingdom 2 United States 9 Global 88

Alchem Pharmtech,Inc.

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View Lastest Price from 3-Amino-5-cyclobutyl-1H-pyrazole manufacturers

Career Henan Chemical Co

Product: 3-Amino-5-cyclobutyl-1H-pyrazole 326827-21-8
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

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