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tert-Butyl (4-methylpiperidin-4-yl)carbamate

Product Name
tert-Butyl (4-methylpiperidin-4-yl)carbamate
CAS No.
163271-08-7
Chemical Name
tert-Butyl (4-methylpiperidin-4-yl)carbamate
Synonyms
4-(Boc-amino)-4-methylpip...;4-Methylpiperidin-4-yl)carbami;4-(Boc-aMino)-4-Methylpiperidine;tert-Butyl (4-methylpiperidin-4-yl);4-Amino-4-methylpiperidine, 4-BOC protected;tert-Butyl N-(4-Methyl-4-piperidyl)carbaMate;tert-Butyl (4-methylpiperidin-4-yl)carbamate;tert-Butyl (4-methyl-4-piperidinyl)carbamate;tert-butyl N-(4-methylpiperidin-4-yl)carbamate;N-(4-Methylpiperidin-1-yl)(tert-butoxy)forMaMide
CBNumber
CB81501982
Molecular Formula
C11H22N2O2
Formula Weight
214.3
MOL File
163271-08-7.mol
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tert-Butyl (4-methylpiperidin-4-yl)carbamate Property

Boiling point:
308 °C
Density 
1.01
Flash point:
140 °C
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
12.75±0.20(Predicted)
form 
powder
color 
Gray
InChI
InChI=1S/C11H22N2O2/c1-10(2,3)15-9(14)13-11(4)5-7-12-8-6-11/h12H,5-8H2,1-4H3,(H,13,14)
InChIKey
MVUNGZMGWJXPIM-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)NC1(C)CCNCC1
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
T206020
Product name
tert-Butyl(4-Methylpiperidin-4-yl)carbamate
Packaging
250mg
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
4H51-1-39
Product name
4-Amino-4-methylpiperidine, 4-Boc protected
Packaging
1g
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB144287
Product name
tert-Butyl (4-methylpiperidin-4-yl)carbamate
Packaging
1g
Price
$100
Updated
2021/12/16
AK Scientific
Product number
W3558
Product name
(4-Methylpiperidin-4-yl)carbamicacidtert-butylester
Packaging
1g
Price
$112
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB144287
Product name
tert-Butyl (4-methylpiperidin-4-yl)carbamate
Packaging
2g
Price
$160
Updated
2021/12/16
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tert-Butyl (4-methylpiperidin-4-yl)carbamate Chemical Properties,Usage,Production

Uses

tert-Butyl (4-methylpiperidin-4-yl)carbamate is versatile intermediates in organic synthesis, particularly in the pharmaceutical industry. They are used in the synthesis of various compounds, including natural products and potential therapeutic agents. 

Synthesis

1262787-56-3

163271-08-7

General procedure for the synthesis of tert-butyl (4-methylpiperidin-4-yl)carbamate from (1-benzoyl-4-methylpiperidin-4-yl)carbamate: 1. tert-Butyl (1-benzoyl-4-methylpiperidin-4-yl)carbamate (318 mg, 1.0 mmol) was dissolved in ethanol (3 mL). 2. 6 N aqueous sodium hydroxide (1.0 mL, 6.0 mmol) was added to the above solution. 3. The reaction mixture was heated at reflux for 8 hours. 4. 4. Upon completion of the reaction, the mixture was concentrated under reduced pressure. 5. Ethyl acetate (30 mL) was added to the concentrated mixture. 6. The organic layer was separated and washed twice with distilled water. 7. Dry the organic layer with anhydrous magnesium sulfate. 8. Concentrate the dried organic layer under reduced pressure and dry under reduced pressure to afford the target product tert-butyl (4-methylpiperidin-4-yl)carbamate (145 mg, 0.67 mmol, 67% yield). Characterization data: Mass spectrum (EI, m/z): 214 [M]+. 1H-NMR (CDCl3) δ: 4.37 (1H, br s), 2.84-2.80 (4H, m), 1.91 (2H, dt, J = 13.3, 3.9 Hz), 1.51 (2H, td, J = 12.9, 6.2 Hz), 1.44 (9H, s), 1.34 (3H, s).

References

[1] Patent: US2012/149902, 2012, A1. Location in patent: Page/Page column 24

tert-Butyl (4-methylpiperidin-4-yl)carbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl (4-methylpiperidin-4-yl)carbamate Suppliers

China 144 India 3 United Kingdom 2 United States 11 Global 160
Accela ChemBio Inc.
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View Lastest Price from tert-Butyl (4-methylpiperidin-4-yl)carbamate manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
tert-Butyl (4-methylpiperidin-4-yl)carbamate 163271-08-7
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2021-09-14
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
tert-Butyl (4-methylpiperidin-4-yl)carbamate 163271-08-7
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10KG
Release date
2021-09-16
Career Henan Chemical Co
Product
tert-Butyl (4-methylpiperidin-4-yl)carbamate 163271-08-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-13

163271-08-7, tert-Butyl (4-methylpiperidin-4-yl)carbamateRelated Search:

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  • tert-Butyl N-(4-Methyl-4-piperidyl)carbaMate
  • N-(4-Methylpiperidin-1-yl)(tert-butoxy)forMaMide
  • 4-Amino-4-methylpiperidine, 4-BOC protected
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  • CarbaMic acid, N-(4-Methyl-4-piperidinyl)-, 1,1-diMethylethyl ester
  • tert-butyl N-(4-methylpiperidin-4-yl)carbamate
  • tert-Butyl (4-methylpiperidin-4-yl)
  • 1,1-Dimethylethyl N-(4-methyl-4-piperidinyl)carbamate
  • 163271-08-7
  • API intermediates