PENTAFLUOROPHENYL TRIFLUOROACETATE
- Product Name
- PENTAFLUOROPHENYL TRIFLUOROACETATE
- CAS No.
- 14533-84-7
- Chemical Name
- PENTAFLUOROPHENYL TRIFLUOROACETATE
- Synonyms
- perfluorophenyl 2,2,2-trifluoroacetate;TFA-OPFP;PFP-O-TFA;PENTAFLUORPHENYL TRIFLUORACETATE;pentafluorophenyl trifloroacetate;PENTAFLUOROPHENYL TRIFLUOROACETATE;Pentafluoropfenyl Trifluoroacetate;PentafluorophenylTrifluoroacetate>Pentafluorophenyl trifluoroacetate 98%;Pentafluorophenyl trifluoroacetate, 98+%
- CBNumber
- CB8151946
- Molecular Formula
- C8F8O2
- Formula Weight
- 280.07
- MOL File
- 14533-84-7.mol
PENTAFLUOROPHENYL TRIFLUOROACETATE Property
- Melting point:
- 4°C(lit.)
- Boiling point:
- 122-123 °C (lit.)
- Density
- 1.63 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.368(lit.)
- Flash point:
- 126 °F
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- form
- Oil
- color
- Clear colorless
- Specific Gravity
- 1.630
- Water Solubility
- Soluble in water at 122.5°Cat760mmHg.
- Sensitive
- Moisture Sensitive
- BRN
- 2003848
- InChI
- InChI=1S/C8F8O2/c9-1-2(10)4(12)6(5(13)3(1)11)18-7(17)8(14,15)16
- InChIKey
- VCQURUZYYSOUHP-UHFFFAOYSA-N
- SMILES
- C(OC1=C(F)C(F)=C(F)C(F)=C1F)(=O)C(F)(F)F
- CAS DataBase Reference
- 14533-84-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,F
- Risk Statements
- 10-36/37/38
- Safety Statements
- 16-26-36
- RIDADR
- UN 3272 3/PG 3
- WGK Germany
- 3
- HazardClass
- 3.2
- PackingGroup
- III
- HS Code
- 29159000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 377074
- Product name
- Pentafluorophenyl trifluoroacetate
- Purity
- 98%
- Packaging
- 5g
- Price
- $77
- Updated
- 2025/07/31
- Product number
- 377074
- Product name
- Pentafluorophenyl trifluoroacetate
- Purity
- 98%
- Packaging
- 25g
- Price
- $205
- Updated
- 2025/07/31
- Product number
- P1894
- Product name
- Pentafluorophenyl Trifluoroacetate
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $61
- Updated
- 2025/07/31
- Product number
- P1894
- Product name
- Pentafluorophenyl Trifluoroacetate
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $206
- Updated
- 2025/07/31
- Product number
- P227320
- Product name
- Pentafluorophenyl trifluoroacetate
- Packaging
- 25g
- Price
- $305
- Updated
- 2021/12/16
PENTAFLUOROPHENYL TRIFLUOROACETATE Chemical Properties,Usage,Production
Chemical Properties
Clear colorless liquid
Uses
It is used as a pharmaceutical intermediate.
Uses
Pentafluorophenyl trifluoroacetate can be used:
- In the esterification of 2′-carboxyrhodamine dye to form pentafluorophenyl ester as a single isomer.
- As an acylating agent and a coupling agent for the peptide-type coupling of N-substituted glycine oligomers.
- In the synthesis of pentafluorophenyl thiophene-3-acetate (PFPTA) by reacting with 3-thiopheneacetic acid.
Synthesis
771-61-9
407-25-0
14533-84-7
1. Pentafluorophenol (50.0 g, 271 mmol) was mixed with trifluoroacetic anhydride (85.0 g, 404 mmol) and the reaction was stirred at 40 °C for 18 hours. 2. The reaction mixture was fractionally distilled and the fractions with boiling points of 122-125 °C were collected to afford trifluoroacetate of pentafluorophenol (75.2 g, 99% yield) as a colorless liquid. 3. in another reaction vessel, oleic acid (30.0 g, 106 mmol) was dissolved in anhydrous DMF (100 mL), and then anhydrous DMF (100 mL) solution of pentafluorophenol trifluoroacetate (32.7 g, 116 mmol) was added. 4. Pyridine (9.16 g, 116 mmol) was slowly added to the above mixture and the reaction was stirred at room temperature for 18 hours. 5. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (200 mL) and washed sequentially with 0.1N hydrochloric acid (100 mL), saturated sodium bicarbonate solution (100 mL) and brine (50 mL). 6. The organic layer was separated, dried with anhydrous magnesium sulfate and concentrated in vacuum to afford oleate pentafluoroacetate (45.0 g, 95% yield) as a colorless viscous liquid.
References
[1] Patent: WO2006/136460, 2006, A2. Location in patent: Page/Page column 32
[2] Tetrahedron Letters, 1990, vol. 31, # 41, p. 5851 - 5852
PENTAFLUOROPHENYL TRIFLUOROACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PENTAFLUOROPHENYL TRIFLUOROACETATE manufacturers
- Product
- PENTAFLUOROPHENYL TRIFLUOROACETATE 14533-84-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-26
- Product
- PENTAFLUOROPHENYL TRIFLUOROACETATE 14533-84-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- PENTAFLUOROPHENYL TRIFLUOROACETATE 14533-84-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08