ChemicalBook > CAS DataBase List > PENTAFLUOROPHENYL TRIFLUOROACETATE

PENTAFLUOROPHENYL TRIFLUOROACETATE

Product Name: PENTAFLUOROPHENYL TRIFLUOROACETATE
CAS No.: 14533-84-7
Chemical Name: PENTAFLUOROPHENYL TRIFLUOROACETATE
Synonyms: perfluorophenyl 2,2,2-trifluoroacetate;TFA-OPFP;PFP-O-TFA;PENTAFLUORPHENYL TRIFLUORACETATE;pentafluorophenyl trifloroacetate;PENTAFLUOROPHENYL TRIFLUOROACETATE;Pentafluoropfenyl Trifluoroacetate;PentafluorophenylTrifluoroacetate>Pentafluorophenyl trifluoroacetate 98%;Pentafluorophenyl trifluoroacetate, 98+%
CBNumber: CB8151946
Molecular Formula: C8F8O2
Formula Weight: 280.07
MOL File: 14533-84-7.mol

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PENTAFLUOROPHENYL TRIFLUOROACETATE Property

Melting point:: 4°C(lit.)
Boiling point:: 122-123 °C (lit.)
Density: 1.63 g/mL at 25 °C (lit.)
refractive index: n20/D 1.368(lit.)
Flash point:: 126 °F
storage temp.: Keep in dark place,Sealed in dry,2-8°C
form: Oil
color: Clear colorless
Specific Gravity: 1.630
Water Solubility: Soluble in water at 122.5°Cat760mmHg.
Sensitive: Moisture Sensitive
BRN: 2003848
InChI: InChI=1S/C8F8O2/c9-1-2(10)4(12)6(5(13)3(1)11)18-7(17)8(14,15)16
InChIKey: VCQURUZYYSOUHP-UHFFFAOYSA-N
SMILES: C(OC1=C(F)C(F)=C(F)C(F)=C1F)(=O)C(F)(F)F
CAS DataBase Reference: 14533-84-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,F
Risk Statements: 10-36/37/38
Safety Statements: 16-26-36
RIDADR: UN 3272 3/PG 3
WGK Germany: 3
HazardClass: 3.2
PackingGroup: III
HS Code: 29159000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 377074
Product name: Pentafluorophenyl trifluoroacetate
Purity: 98%
Packaging: 5g
Price: $77
Updated: 2025/07/31

Sigma-Aldrich

Product number: 377074
Product name: Pentafluorophenyl trifluoroacetate
Purity: 98%
Packaging: 25g
Price: $205
Updated: 2025/07/31

TCI Chemical

Product number: P1894
Product name: Pentafluorophenyl Trifluoroacetate
Purity: >95.0%(GC)
Packaging: 5g
Price: $61
Updated: 2025/07/31

TCI Chemical

Product number: P1894
Product name: Pentafluorophenyl Trifluoroacetate
Purity: >95.0%(GC)
Packaging: 25g
Price: $206
Updated: 2025/07/31

TRC

Product number: P227320
Product name: Pentafluorophenyl trifluoroacetate
Packaging: 25g
Price: $305
Updated: 2021/12/16

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PENTAFLUOROPHENYL TRIFLUOROACETATE Chemical Properties,Usage,Production

Chemical Properties

Clear colorless liquid

Uses

It is used as a pharmaceutical intermediate.

Uses

Pentafluorophenyl trifluoroacetate can be used:

In the esterification of 2′-carboxyrhodamine dye to form pentafluorophenyl ester as a single isomer.
As an acylating agent and a coupling agent for the peptide-type coupling of N-substituted glycine oligomers.
In the synthesis of pentafluorophenyl thiophene-3-acetate (PFPTA) by reacting with 3-thiopheneacetic acid.

Synthesis

771-61-9

407-25-0

14533-84-7

1. Pentafluorophenol (50.0 g, 271 mmol) was mixed with trifluoroacetic anhydride (85.0 g, 404 mmol) and the reaction was stirred at 40 °C for 18 hours. 2. The reaction mixture was fractionally distilled and the fractions with boiling points of 122-125 °C were collected to afford trifluoroacetate of pentafluorophenol (75.2 g, 99% yield) as a colorless liquid. 3. in another reaction vessel, oleic acid (30.0 g, 106 mmol) was dissolved in anhydrous DMF (100 mL), and then anhydrous DMF (100 mL) solution of pentafluorophenol trifluoroacetate (32.7 g, 116 mmol) was added. 4. Pyridine (9.16 g, 116 mmol) was slowly added to the above mixture and the reaction was stirred at room temperature for 18 hours. 5. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (200 mL) and washed sequentially with 0.1N hydrochloric acid (100 mL), saturated sodium bicarbonate solution (100 mL) and brine (50 mL). 6. The organic layer was separated, dried with anhydrous magnesium sulfate and concentrated in vacuum to afford oleate pentafluoroacetate (45.0 g, 95% yield) as a colorless viscous liquid.

References

[1] Patent: WO2006/136460, 2006, A2. Location in patent: Page/Page column 32
[2] Tetrahedron Letters, 1990, vol. 31, # 41, p. 5851 - 5852

PENTAFLUOROPHENYL TRIFLUOROACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PENTAFLUOROPHENYL TRIFLUOROACETATE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: PENTAFLUOROPHENYL TRIFLUOROACETATE 14533-84-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: PENTAFLUOROPHENYL TRIFLUOROACETATE 14533-84-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: PENTAFLUOROPHENYL TRIFLUOROACETATE 14533-84-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

14533-84-7, PENTAFLUOROPHENYL TRIFLUOROACETATERelated Search:

α-Bromo-2,3,4,5,6-pentafluorotoluene O-(2,2,2-Trifluoroethyl)hydroxylamine hydrochloride TRIFLUOROACETALDEHYDE HYDRATE PENTAFLUOROPHENYLHYDRAZINE TRIFLUOROMETHANESULFONIC ACID TRIFLUOROMETHYL ESTER Tetramethylammonium trifluoromethanethiolate Phthalates Lithium hydroxide Pentafluorophenol Methyl trifluoroacetate PENTAFLUOROPHENYL TRIFLUOROACETATE 2,3,4,5,6-PENTAFLUOROANISOLE PHENYL TRIFLUOROACETATE 2,3,5,6-Tetrafluorophenol Trifluoroacetic acid 2,3,5,6-TETRAFLUOROANISOLE 2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE PENTAFLUORO-(2,2,2-TRIFLUOROETHOXY)BENZENE

PFP-O-TFA

PENTAFLUOROPHENYL TRIFLUOROACETATE

PENTAFLUORPHENYL TRIFLUORACETATE

TRIFLUORO ACETIC ACID PENTAFLUORO PHENYL ESTER

TFA-OPFP

Pentafluoropfenyl Trifluoroacetate

Pentafluorophenyl trifluoroacetate,Trifluoroacetic acid pentafluorophenyl ester

Pentafluorophenyl trifluoroacetate, 98+%

perfluorophenyl 2,2,2-trifluoroacetate

Acetic acid,2,2,2-trifluoro-, 2,3,4,5,6-pentafluorophenyl ester

Pentafluorophenyl trifluoroacetate 98%

Perfluoro(phenyl acetate), Trifluoroacetic acid pentafluorophenyl ester

pentafluorophenyl trifloroacetate

2,2,2-Trifluoro-acetic Acid 2,3,4,5,6-Pentafluorophenyl Ester

PentafluorophenylTrifluoroacetate&gt

(2,3,4,5,6-pentafluorophenyl) 2,2,2-trifluoroacetate

PENTAFLUOROPHENYL 2,2,2-TRIFLUOROACETATE

14533-84-7

C8F8O2

CF3CO2C6F5

Active Esters/Additives

Coupling

Synthetic Reagents