ChemicalBook > CAS DataBase List > Methyl 2-amino-4,5-dimethoxybenzoate

Methyl 2-amino-4,5-dimethoxybenzoate

Product Name
Methyl 2-amino-4,5-dimethoxybenzoate
CAS No.
26759-46-6
Chemical Name
Methyl 2-amino-4,5-dimethoxybenzoate
Synonyms
METHYL 6-AMINOVERATRATE;Methyl 2-aMino-4;TIMTEC-BB SBB008554;5-diMethoxy benzoate;LABOTEST-BB LT00454153;Gefitinib interMediate I;METHYL 4,5-DIMETHOXYANTHRANILATE;6-AMINOVERATRIC ACID METHYL ESTER;Methyl4,5-Dimethoxyanthranilate>2-amino-4,5-dimethoxy-benzate ester
CBNumber
CB8153869
Molecular Formula
C10H13NO4
Formula Weight
211.21
MOL File
26759-46-6.mol
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Methyl 2-amino-4,5-dimethoxybenzoate Property

Melting point:
128-133 °C
Boiling point:
343.1±37.0 °C(Predicted)
Density 
1.189±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
2.68±0.10(Predicted)
color 
White to Light yellow to Light orange
BRN 
2724754
InChI
InChI=1S/C10H13NO4/c1-13-8-4-6(10(12)15-3)7(11)5-9(8)14-2/h4-5H,11H2,1-3H3
InChIKey
QQFHCCQSCQBKBG-UHFFFAOYSA-N
SMILES
C(OC)(=O)C1=CC(OC)=C(OC)C=C1N
CAS DataBase Reference
26759-46-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25-22
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29225090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
07725
Product name
Methyl 2-amino-4,5-dimethoxybenzoate
Purity
≥98.0% (HPLC/NT)
Packaging
25g
Price
$61.3
Updated
2023/06/20
TCI Chemical
Product number
D2749
Product name
Methyl 4,5-Dimethoxyanthranilate
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$45
Updated
2025/07/31
Usbiological
Product number
454818
Product name
Methyl 2-amino-4,5-dimethoxybenzoate
Packaging
500mg
Price
$305
Updated
2021/12/16
Usbiological
Product number
454789
Product name
Methyl 2-amino-4-
Packaging
100mg
Price
$305
Updated
2021/12/16
Usbiological
Product number
454796
Product name
Methyl 2-amino-4-
Packaging
100mg
Price
$319
Updated
2021/12/16
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Methyl 2-amino-4,5-dimethoxybenzoate Chemical Properties,Usage,Production

Chemical Properties

Brown crystalline powder

Uses

3-Acetamido-2-hydroxyacetophenone is used in the preparation fo Antitumor Agents in Breast Cancer.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

26791-93-5

26759-46-6

General procedure for the synthesis of methyl 2-amino-4,5-dimethoxybenzoate from methyl 4,5-dimethoxy-2-nitrobenzoate: 1.9 g (7.2 mmol) of methyl 4,5-dimethoxy-2-nitrobenzoate and 0.2 g of palladium-carbon catalyst were added to a 100 mL round-bottomed flask and dissolved in 50 mL of methanol. Hydrogen was passed into the reaction system and the reaction mixture was stirred at room temperature for 24 hours. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the brown solid catalyst was removed by filtration. The product was separated and purified by column chromatography (eluent ratio: petroleum ether:ethyl acetate = 10:1, V/V) to afford 1.51 g of the white solid target compound in 88.7% yield with a melting point of 91-93°C. The product was purified by column chromatography (eluent ratio: petroleum ether:ethyl acetate = 10:1, V/V).

References

[1] Patent: CN105037279, 2017, B. Location in patent: Paragraph 0047; 0048
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 18, p. 4455 - 4459
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995, vol. 34, # 10, p. 911 - 913
[4] Justus Liebigs Annalen der Chemie, 1896, vol. 293, p. 190
[5] Journal of the American Chemical Society, 1919, vol. 41, p. 2147

Methyl 2-amino-4,5-dimethoxybenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl 2-amino-4,5-dimethoxybenzoate manufacturers

Zibo Shiji Zhonglian Medical Technology Co., Ltd.
Product
Methyl 2-amino-4,5-dimethoxybenzoate 26759-46-6
Price
US $0.00/KG
Min. Order
25KG
Purity
99.8%
Supply Ability
2000KG/th
Release date
2023-02-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
Methyl 2-amino-4,5-dimethoxybenzoate 26759-46-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Methyl 2-amino-4,5-dimethoxybenzoate 26759-46-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

26759-46-6, Methyl 2-amino-4,5-dimethoxybenzoateRelated Search:

Methyl acrylate Acetonitrile 3,5-Dimethoxybenzoic acid 4-Methoxybenzoic acid Kresoxim-methyl Methylparaben Methyl anthranilate Basic Violet 1 4-Dimethylaminobenzoic acid Methyl benzoate 4-Aminobenzoic acid Paraquat dichloride Methanol Methyl acetate Glycine Methyl Anthranilic acid ETHYL 4,5-DIMETHOXY-2-NITROBENZOATE

  • 2-AMINO-4,5-DIMETHOXYBENZOIC ACID METHYL ESTER
  • 2-AMINO-4,5-DIMETHOXY METHYL BENZOATE
  • 4,5-DIMETHOXYANTHRANILIC ACID METHYL
  • 4,5-DIMETHOXYANTHRANILIC ACID METHYL ESTER
  • 6-AMINOVERATRIC ACID METHYL ESTER
  • METHYL 6-AMINO-3,4-DIMETHOXYBENZOATE
  • METHYL 6-AMINOVERATRATE
  • METHYL 4,5-DIMETHOXYANTHRANILATE
  • 2-Amino-4,5-Dimethoxy Benzoate de methyl
  • 3,4-Dimethoxy-6-Aminomethyl Benzoate
  • METHYL 2-AMINO-4,5-DIMETHOXYBENZOATE
  • LABOTEST-BB LT00454153
  • TIMTEC-BB SBB008554
  • 2-amino-4,5-dimethoxy-benzate ester
  • 6-AMINO-3,4-DIMETHOXYBENZOIC ACID METHYL ESTER
  • 4,5-DIMETHOXY-2-AMINOBENZOIC ACID METHYL ESTER
  • 3,4-DIMETHOXY-6-AMINOBENZOICACIDMETHYLESTER
  • Benzoicacid,2-amino-4,5-dimethoxy-methylester
  • Methyl 4,5-dimethoxyanthranilate, Methyl 6-aminoveratrate
  • 5-diMethoxy benzoate
  • Methyl 2-aMino-4
  • Gefitinib interMediate I
  • 2-Amino-4,5-dimethoxybenzoic Acid Methyl Ester 6-Aminoveratric Acid Methyl Ester 4,5-Dimethoxyanthranilic Acid Methyl Ester Methyl 2-Amino-4,5-dimethoxybenzoate Methyl 6-Aminoveratrate
  • 3'-AcetaMido-2'-hydroxyacetophenone
  • Methyl4,5-Dimethoxyanthranilate&gt
  • Benzoic acid, 2-amino-4,5-dimethoxy-, methyl ester (9CI, ACI)
  • 2-amino-4,5-dimethoxy-Benzoic acid methyl ester (9CI ACI)
  • 26759-46-6
  • C10H13NO4
  • Unnatural Amino Acid Derivatives
  • Peptide Synthesis
  • Specialty Synthesis
  • Aromatic Amino Acids
  • FINE Chemical & INTERMEDIATES
  • Aromatic Esters
  • Organic acids