Methyl 2-amino-4,5-dimethoxybenzoate
- Product Name
- Methyl 2-amino-4,5-dimethoxybenzoate
- CAS No.
- 26759-46-6
- Chemical Name
- Methyl 2-amino-4,5-dimethoxybenzoate
- Synonyms
- METHYL 6-AMINOVERATRATE;Methyl 2-aMino-4;TIMTEC-BB SBB008554;5-diMethoxy benzoate;LABOTEST-BB LT00454153;Gefitinib interMediate I;METHYL 4,5-DIMETHOXYANTHRANILATE;6-AMINOVERATRIC ACID METHYL ESTER;Methyl4,5-Dimethoxyanthranilate>2-amino-4,5-dimethoxy-benzate ester
- CBNumber
- CB8153869
- Molecular Formula
- C10H13NO4
- Formula Weight
- 211.21
- MOL File
- 26759-46-6.mol
Methyl 2-amino-4,5-dimethoxybenzoate Property
- Melting point:
- 128-133 °C
- Boiling point:
- 343.1±37.0 °C(Predicted)
- Density
- 1.189±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 2.68±0.10(Predicted)
- color
- White to Light yellow to Light orange
- BRN
- 2724754
- InChI
- InChI=1S/C10H13NO4/c1-13-8-4-6(10(12)15-3)7(11)5-9(8)14-2/h4-5H,11H2,1-3H3
- InChIKey
- QQFHCCQSCQBKBG-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC(OC)=C(OC)C=C1N
- CAS DataBase Reference
- 26759-46-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25-22
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29225090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 07725
- Product name
- Methyl 2-amino-4,5-dimethoxybenzoate
- Purity
- ≥98.0% (HPLC/NT)
- Packaging
- 25g
- Price
- $61.3
- Updated
- 2023/06/20
- Product number
- D2749
- Product name
- Methyl 4,5-Dimethoxyanthranilate
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- 454818
- Product name
- Methyl 2-amino-4,5-dimethoxybenzoate
- Packaging
- 500mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 454789
- Product name
- Methyl 2-amino-4-
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 454796
- Product name
- Methyl 2-amino-4-
- Packaging
- 100mg
- Price
- $319
- Updated
- 2021/12/16
Methyl 2-amino-4,5-dimethoxybenzoate Chemical Properties,Usage,Production
Chemical Properties
Brown crystalline powder
Uses
3-Acetamido-2-hydroxyacetophenone is used in the preparation fo Antitumor Agents in Breast Cancer.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
26791-93-5
26759-46-6
General procedure for the synthesis of methyl 2-amino-4,5-dimethoxybenzoate from methyl 4,5-dimethoxy-2-nitrobenzoate: 1.9 g (7.2 mmol) of methyl 4,5-dimethoxy-2-nitrobenzoate and 0.2 g of palladium-carbon catalyst were added to a 100 mL round-bottomed flask and dissolved in 50 mL of methanol. Hydrogen was passed into the reaction system and the reaction mixture was stirred at room temperature for 24 hours. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the brown solid catalyst was removed by filtration. The product was separated and purified by column chromatography (eluent ratio: petroleum ether:ethyl acetate = 10:1, V/V) to afford 1.51 g of the white solid target compound in 88.7% yield with a melting point of 91-93°C. The product was purified by column chromatography (eluent ratio: petroleum ether:ethyl acetate = 10:1, V/V).
References
[1] Patent: CN105037279, 2017, B. Location in patent: Paragraph 0047; 0048
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 18, p. 4455 - 4459
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995, vol. 34, # 10, p. 911 - 913
[4] Justus Liebigs Annalen der Chemie, 1896, vol. 293, p. 190
[5] Journal of the American Chemical Society, 1919, vol. 41, p. 2147
Methyl 2-amino-4,5-dimethoxybenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 2-amino-4,5-dimethoxybenzoate Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
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- Advantage
- 80
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View Lastest Price from Methyl 2-amino-4,5-dimethoxybenzoate manufacturers
- Product
- Methyl 2-amino-4,5-dimethoxybenzoate 26759-46-6
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 99.8%
- Supply Ability
- 2000KG/th
- Release date
- 2023-02-09
- Product
- Methyl 2-amino-4,5-dimethoxybenzoate 26759-46-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- Methyl 2-amino-4,5-dimethoxybenzoate 26759-46-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09