4-Bromo-2-fluorobiphenyl

Product Name: 4-Bromo-2-fluorobiphenyl
CAS No.: 41604-19-7
Chemical Name: 4-Bromo-2-fluorobiphenyl
Synonyms: BFBP;C12HgBrF;cas no.:41604-19-7;Bromo-2-fluorobiphenyl;Flurbiprofen impurityⅠ;Flurbiprofen impurityⅠ;Flurbiprofen Impurity 9;4-BROMO-2-FLUORODIPHENYL;4-BROMO-2-FLUOROBIPHENYL;2-FLUORO-4-BROMO BIPHENYL
CBNumber: CB8158970
Molecular Formula: C12H8BrF
Formula Weight: 251.09
MOL File: 41604-19-7.mol

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4-Bromo-2-fluorobiphenyl Property

Melting point:: 39-41 °C(lit.)
Boiling point:: 175°C 2mm
Density: 1.40
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in DMSO, Methanol
form: Crystalline Powder or Chunks
color: Off-white to pale yellow
Water Solubility: insoluble
BRN: 2208913
InChI: InChI=1S/C12H8BrF/c13-10-6-7-11(12(14)8-10)9-4-2-1-3-5-9/h1-8H
InChIKey: HTRNHWBOBYFTQF-UHFFFAOYSA-N
SMILES: C1(C2=CC=CC=C2)=CC=C(Br)C=C1F
CAS DataBase Reference: 41604-19-7(CAS DataBase Reference)
NIST Chemistry Reference: 4-Bromo-2-fluorobiphenyl(41604-19-7)

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Safety

Hazard Codes: Xi,Xn,N
Risk Statements: 22-36/37/38-20/21/22-50/53-36/38
Safety Statements: 36/37/39-36-26-61-60
RIDADR: UN 3152 9/PG 2
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 9
PackingGroup: II
HS Code: 29036990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 367583
Product name: 4-Bromo-2-fluorobiphenyl
Purity: 99%
Packaging: 10g
Price: $51
Updated: 2023/01/07

TCI Chemical

Product number: B2028
Product name: 4-Bromo-2-fluorobiphenyl
Purity: >99.0%(GC)
Packaging: 5g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: B2028
Product name: 4-Bromo-2-fluorobiphenyl
Purity: >99.0%(GC)
Packaging: 25g
Price: $154
Updated: 2025/07/31

TCI Chemical

Product number: B2028
Product name: 4-Bromo-2-fluorobiphenyl
Purity: >99.0%(GC)
Packaging: 250g
Price: $572
Updated: 2023/06/20

TRC

Product number: B684405
Product name: 4-Bromo-2-fluoro-1,1''-biphenyl
Packaging: 10g
Price: $60
Updated: 2021/12/16

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4-Bromo-2-fluorobiphenyl Chemical Properties,Usage,Production

Chemical Properties

Pale yellow crystalline

Uses

An intermediate in the preparation of non-steroidal anti-inflammatory drugs as well as other bio-active compounds.

Synthesis

367-24-8

7439-89-6

41604-19-7

General procedure for the synthesis of 4-bromo-2-fluorobiphenyl from 4-bromo-2-fluoroaniline and iron powder: (1) A solution of 96 g (0.50 mol) of crude 4-bromo-2-fluoroaniline and 60.0 g (1.0 mol) of glacial acetic acid in 100 ml of benzene was added dropwise over a period of 7 hours to a mixture of 69.0 g (1.0 mol) of sodium nitrite, 69 ml of water and 700 ml of benzene. The temperature was maintained at 65°C. Subsequently, the reaction mixture was stirred at 65°C for 12 hours under nitrogen protection. Upon completion of the reaction, the cooled mixture was washed twice with 400 mL of 1N hydrochloric acid. Next, 20 g (0.36 mol) of iron powder, 250 mL of methanol and 150 mL (1.8 mol) of concentrated hydrochloric acid were added and heated at reflux for 13 hours. After the reaction solution was cooled, the benzene layer was washed with 490 ml of water and the solvent was evaporated under reduced pressure at 40 °C/40 mmHg. Finally, the dark-colored oily material obtained was distilled at a pressure of 10 mmHg and the fractions with boiling points of 132-141 °C/8 mmHg were collected to give 64.6 g (51.5% yield) of 4-bromo-2-fluorobiphenyl. The product crystallized after inoculation with crystal seed. A variant of the sodium nitrite method was used to synthesize 4-bromo-2-fluorobiphenyl IV1 and the corresponding results were obtained as shown in Table I.

References

[1] Patent: US4443631, 1984, A
[2] Patent: US4518799, 1985, A

4-Bromo-2-fluorobiphenyl Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-2-fluorobiphenyl Suppliers

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View Lastest Price from 4-Bromo-2-fluorobiphenyl manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 4-Bromo-2-fluorobiphenyl 41604-19-7
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-21

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Bromo-2-fluorobiphenyl 41604-19-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-11

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Bromo-2-fluorobiphenyl 41604-19-7
Price: US $100.60/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000kg
Release date: 2024-08-20

41604-19-7, 4-Bromo-2-fluorobiphenylRelated Search:

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4-BROMO-2-FLUOROBIPHENYL

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4-BROMO-2-FLUOROBIPHENYL FOR SYNTHESIS

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cas no.:41604-19-7

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best offer 4-Bromo-2-fluorobiphenyl

4-Bromo-2-Fluorobiphenyl pure, 98%

4-bromo-2-fluoro biphenyl (Campaign Base)

C12HgBrF

4-Bromo-2-fluoro-1,1'-biphenyl

Flurbiprofen impurityⅠ

41604-19-7

1604-19-7

416064-19-7

C12H8BrF

C6H5C6H3BrF

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