ChemicalBook > CAS DataBase List > 5-Bromo-2,3-dihydro-1-benzofuran

5-Bromo-2,3-dihydro-1-benzofuran

Product Name: 5-Bromo-2,3-dihydro-1-benzofuran
CAS No.: 66826-78-6
Chemical Name: 5-Bromo-2,3-dihydro-1-benzofuran
Synonyms: 5-BROMO-2,3-DIHYDROBENZOFURAN;5-BROMO-2,3-DIHYDROBENZO[B]FURAN;5-Bromocoumaran;BUTTPARK 36\18-16;2,3-Dihydro-5-broMobenzofuran;5-BROMO-2,3-DIHYDRO-1-BENZOFURAN;Benzofuran, 5-bromo-2,3-dihydro-;5-Bromo-2,3-dihydrobenzofuran >6-bromo-5-methyl-2,3-dihydrobenzofuran
CBNumber: CB8176538
Molecular Formula: C8H7BrO
Formula Weight: 199.04
MOL File: 66826-78-6.mol

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5-Bromo-2,3-dihydro-1-benzofuran Property

Melting point:: 49 °C
Boiling point:: 251.7±29.0 °C(Predicted)
Density: 1.582±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
color: White to Light yellow
CAS DataBase Reference: 66826-78-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-52-22
Safety Statements: 26-36/37/39-37/39
HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4318
Product name: 5-Bromo-2,3-dihydrobenzofuran
Purity: >98.0%(GC)
Packaging: 5g
Price: $73
Updated: 2025/07/31

TRC

Product number: B683495
Product name: 5-Bromo-2,3-dihydrobenzofuran
Packaging: 10g
Price: $140
Updated: 2021/12/16

Apolloscientific

Product number: OR22995
Product name: 5-Bromo-2,3-dihydrobenzo[b]furan
Packaging: 5g
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB11160
Product name: 5-Bromo-2,3-dihydrobenzo[b]furan
Packaging: 10g
Price: $150
Updated: 2021/12/16

Apolloscientific

Product number: OR22995
Product name: 5-Bromo-2,3-dihydrobenzo[b]furan
Packaging: 25g
Price: $169
Updated: 2021/12/16

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5-Bromo-2,3-dihydro-1-benzofuran Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

5-Bromo-2,3-dihydrobenzofuran, is an organic building block that can be used in the synthesis of Darifenacin (D193400), a drug used to treat urinary incontinence.

Synthesis

496-16-2

66826-78-6

General procedure for the synthesis of 5-bromo-2,3-dihydrobenzofuran from 2,3-dihydrobenzofuran: Liquid bromine (2.66 g) was added slowly and dropwise to dioxane (30 mL) under cooling conditions in an ice bath and stirred for 30 min at this temperature. Subsequently, 2,3-dihydrobenzofuran (2 g) was added dropwise to the reaction mixture and stirring was continued for 3 hours at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (50 mL), washed sequentially with saturated aqueous sodium bicarbonate and brine, and dried over anhydrous magnesium sulfate. The solvent was removed by evaporation to give an orange oily crude product. The crude product was purified by silica gel column chromatography (eluent: hexane-ethyl acetate, 20:1) to afford 2.33 g of 5-bromo-2,3-dihydrobenzofuran white crystals in 70.3% yield. The product was characterized by 1H-NMR (300 MHz, CDCl3, δ): 3.11 (2H, t, J = 11 Hz), 4.57 (2H, t, J = 11 Hz), 6.66 (1H, d, J = 8 Hz), 7.20 (1H, d, J = 8 Hz), 7.30 (1H, s).

References

[1] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 16, p. 4313 - 4336
[2] Chemistry - A European Journal, 2017, vol. 23, # 5, p. 1044 - 1047
[3] Synthesis, 1988, # 12, p. 950 - 952
[4] Patent: US6333324, 2001, B1
[5] Patent: WO2003/82787, 2003, A1. Location in patent: Page/Page column 137-138

5-Bromo-2,3-dihydro-1-benzofuran Preparation Products And Raw materials

Raw materials

Preparation Products

2,3-DIHYDROBENZOFURAN-5-BORONIC ACID

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View Lastest Price from 5-Bromo-2,3-dihydro-1-benzofuran manufacturers

LY Global chemicals co.,ltd .

Product: 5-Bromo-2,3-dihydro-1-benzofuran 66826-78-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98.0%min
Supply Ability: 100kg
Release date: 2023-03-19

Career Henan Chemical Co

Product: 5-Bromo-2,3-dihydro-1-benzofuran 66826-78-6
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-09

66826-78-6, 5-Bromo-2,3-dihydro-1-benzofuranRelated Search:

Potassium hydrogen phthalate Tetrahydrofuran 5-Bromo-1-benzofuran 2,3-Dihydrobenzofuran Decabromodiphenyl Ethane Dihydromyrcenol Benzofuran 5-BROMO-3-IODO (1H)INDAZOLE 6-chloro-2,3-dimethylpyridine(SALTDATA: FREE) 5-Bromo-3(2H)-benzofuranone 5-BROMO-2,3-DIHYDROBENZO[B]FURAN-7-CARBONYL CHLORIDE 5-BROMO-2,3-DIHYDROBENZO[B]FURAN-7-SULFONYL CHLORIDE 5-BROMO-2,3-DIHYDROBENZOFURAN-7-CARBOXYLIC ACID Bromine POLY(TETRAHYDROFURAN) STANDARD 15000 5-BROMO-2,3-DIHYDROBENZO[B]FURAN-7-CARBALDEHYDE 5,7-DIBROMO-2,3-DIHYDROBENZOFURAN 5-BROMO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE

5-BROMO-2,3-DIHYDRO-1-BENZOFURAN

5-BROMO-2,3-DIHYDROBENZOFURAN

5-BROMO-2,3-DIHYDROBENZO[B]FURAN

BUTTPARK 36\18-16

2,3-Dihydro-5-broMobenzofuran

Benzofuran, 5-bromo-2,3-dihydro-

6-bromo-5-methyl-2,3-dihydrobenzofuran

5-Bromo-2,3-dihydrobenzofuran &gt

5-Bromocoumaran

66826-78-6

ARYL HALIDE

Heterocyclic Compounds

blocks

Bromides

BuildingBlocks

Furan&Benzofuran