5-Bromo-2,3-dihydro-1-benzofuran
- Product Name
- 5-Bromo-2,3-dihydro-1-benzofuran
- CAS No.
- 66826-78-6
- Chemical Name
- 5-Bromo-2,3-dihydro-1-benzofuran
- Synonyms
- 5-BROMO-2,3-DIHYDROBENZOFURAN;5-BROMO-2,3-DIHYDROBENZO[B]FURAN;5-Bromocoumaran;BUTTPARK 36\18-16;2,3-Dihydro-5-broMobenzofuran;5-BROMO-2,3-DIHYDRO-1-BENZOFURAN;Benzofuran, 5-bromo-2,3-dihydro-;5-Bromo-2,3-dihydrobenzofuran >6-bromo-5-methyl-2,3-dihydrobenzofuran
- CBNumber
- CB8176538
- Molecular Formula
- C8H7BrO
- Formula Weight
- 199.04
- MOL File
- 66826-78-6.mol
5-Bromo-2,3-dihydro-1-benzofuran Property
- Melting point:
- 49 °C
- Boiling point:
- 251.7±29.0 °C(Predicted)
- Density
- 1.582±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Light yellow
- CAS DataBase Reference
- 66826-78-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-52-22
- Safety Statements
- 26-36/37/39-37/39
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B4318
- Product name
- 5-Bromo-2,3-dihydrobenzofuran
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $73
- Updated
- 2025/07/31
- Product number
- B683495
- Product name
- 5-Bromo-2,3-dihydrobenzofuran
- Packaging
- 10g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- OR22995
- Product name
- 5-Bromo-2,3-dihydrobenzo[b]furan
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 2H10-9-X6
- Product name
- 5-Bromo-2,3-dihydrobenzo[b]furan
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
- Product number
- OR22995
- Product name
- 5-Bromo-2,3-dihydrobenzo[b]furan
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
5-Bromo-2,3-dihydro-1-benzofuran Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Uses
5-Bromo-2,3-dihydrobenzofuran, is an organic building block that can be used in the synthesis of Darifenacin (D193400), a drug used to treat urinary incontinence.
Synthesis
496-16-2
66826-78-6
General procedure for the synthesis of 5-bromo-2,3-dihydrobenzofuran from 2,3-dihydrobenzofuran: Liquid bromine (2.66 g) was added slowly and dropwise to dioxane (30 mL) under cooling conditions in an ice bath and stirred for 30 min at this temperature. Subsequently, 2,3-dihydrobenzofuran (2 g) was added dropwise to the reaction mixture and stirring was continued for 3 hours at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (50 mL), washed sequentially with saturated aqueous sodium bicarbonate and brine, and dried over anhydrous magnesium sulfate. The solvent was removed by evaporation to give an orange oily crude product. The crude product was purified by silica gel column chromatography (eluent: hexane-ethyl acetate, 20:1) to afford 2.33 g of 5-bromo-2,3-dihydrobenzofuran white crystals in 70.3% yield. The product was characterized by 1H-NMR (300 MHz, CDCl3, δ): 3.11 (2H, t, J = 11 Hz), 4.57 (2H, t, J = 11 Hz), 6.66 (1H, d, J = 8 Hz), 7.20 (1H, d, J = 8 Hz), 7.30 (1H, s).
References
[1] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 16, p. 4313 - 4336
[2] Chemistry - A European Journal, 2017, vol. 23, # 5, p. 1044 - 1047
[3] Synthesis, 1988, # 12, p. 950 - 952
[4] Patent: US6333324, 2001, B1
[5] Patent: WO2003/82787, 2003, A1. Location in patent: Page/Page column 137-138
5-Bromo-2,3-dihydro-1-benzofuran Preparation Products And Raw materials
Raw materials
Preparation Products
5-Bromo-2,3-dihydro-1-benzofuran Suppliers
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- 021-31261262/ 49 (0)17662837245
- Fax
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- Germany
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- ProdList
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View Lastest Price from 5-Bromo-2,3-dihydro-1-benzofuran manufacturers
- Product
- 5-Bromo-2,3-dihydro-1-benzofuran 66826-78-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98.0%min
- Supply Ability
- 100kg
- Release date
- 2023-03-19
- Product
- 5-Bromo-2,3-dihydro-1-benzofuran 66826-78-6
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09