ChemicalBook > CAS DataBase List > Triethylenetetramine

Triethylenetetramine

Product Name
Triethylenetetramine
CAS No.
112-24-3
Chemical Name
Triethylenetetramine
Synonyms
TETA;Trientine;TRIEN;triethylentetramine;TRIETHYLENETETRAMINE (TETA);3,6-Diazaoctanethylenediamin;N1-[2-(2-Amino-ethylamino)-ethyl]-ethane-1,2-diamine;TECZA;hy951;deh24
CBNumber
CB8183772
Molecular Formula
C6H18N4
Formula Weight
146.23
MOL File
112-24-3.mol
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Triethylenetetramine Property

Melting point:
12 °C(lit.)
Boiling point:
266-267 °C(lit.)
Density 
0.982 g/mL at 25 °C(lit.)
vapor density 
~5 (vs air)
vapor pressure 
<0.01 mm Hg ( 20 °C)
refractive index 
n20/D 1.496(lit.)
Flash point:
290 °F
storage temp. 
Store below +30°C.
solubility 
alcohol: soluble
pka
pK1:3.32(+4);pK2:6.67(+3);pK3:9.20(+2);pK4:9.92(+1) (20°C)
form 
Slightly viscous yellow liquid; commercially available form is 95–98% pure, and impurities include linear, branched, and cyclic isomers.
color 
Yellowish liquid or oil
PH
10-11 (10g/l, H2O, 20℃)
explosive limit
0.7-7.2%(V)
Water Solubility 
SOLUBLE
FreezingPoint 
12℃
Sensitive 
Moisture Sensitive
Merck 
14,9663
BRN 
605448
Exposure limits
ACGIH: TWA 1 ppm (Skin)
NIOSH: TWA 1 ppm(4 mg/m3)
Stability:
Incompatible with strong oxidizing agents, strong acids.
LogP
-2.65 at 20℃
CAS DataBase Reference
112-24-3(CAS DataBase Reference)
NIST Chemistry Reference
Triethylenetetramine(112-24-3)
EPA Substance Registry System
Triethylenetetramine (112-24-3)
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Safety

Hazard Codes 
C
Risk Statements 
21-34-43-52/53
Safety Statements 
26-36/37/39-45-61
RIDADR 
UN 2259 8/PG 2
WGK Germany 
2
RTECS 
YE6650000
Autoignition Temperature
335 °C
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29212900
Hazardous Substances Data
112-24-3(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 2.5 g/kg (Spitz)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.14392
Product name
Triethylenetetramine
Purity
(mixture of isomers) for synthesis
Packaging
100mL
Price
$35.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14392
Product name
Triethylenetetramine
Purity
(mixture of isomers) for synthesis
Packaging
500mL
Price
$61.9
Updated
2024/03/01
Sigma-Aldrich
Product number
132098
Product name
Triethylenetetramine
Purity
technical grade, 60%
Packaging
1kg
Price
$78.4
Updated
2024/03/01
Sigma-Aldrich
Product number
132098
Product name
Triethylenetetramine
Purity
technical grade, 60%
Packaging
2kg
Price
$135
Updated
2024/03/01
TCI Chemical
Product number
T0429
Product name
Triethylenetetramine
Purity
>60.0%(GC)
Packaging
25mL
Price
$22
Updated
2024/03/01
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Triethylenetetramine Chemical Properties,Usage,Production

Description

Cross sensitivity is possible with diethylenetriamine and diethylenediamine.

Chemical Properties

Triethylenetetramine is a corrosive liquid.

Uses

Triethylenetetramine is used in synthesis of detergents, softeners, and dyestuffs; manufacture of pharmaceuticals; vulcanization accelerator of rubber; thermo setting resin; epoxy curing agent; lubricating-oil additive; analytical reagent for Cu, Ni; chelating agent; treatment of Wilson's disease.

Uses

Triethylenetetramine is a selective CuII-chelator; crosslinking agent. Triethylenetetramine is undergoing trials for the treatment of heart failure in patients with diabetes.

Uses

Triethylenetetramine is used as an amine hardener in epoxy resin of the bisphenol A type.

Production Methods

TETA is manufactured by reacting ethylene dichloride and ammonia under controlled conditions.

Definition

ChEBI: 2,2,2-tetramine is a polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens. It has a role as a copper chelator. It is a tetramine and a polyazaalkane.

brand name

Syprine (Merck).

General Description

A yellowish liquid. Less dense than water. Combustible, though may be difficult to ignite. Corrosive to metals and tissue. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used in detergents and in the synthesis of dyes, pharmaceuticals and other chemicals.

Chemical Properties

Triethylenetetramine (TETA) is hygroscopic, corrosive, and has a strong ammoniacal odor. With water a crystalline hydrate is formed. Like DETA, it is completely miscible with water and many polar organic solvents, but less so with lipids; with CCl4 a violent reaction occurs. Its four pKa values are 3.32, 6.67, 9.20, and 9.92. Technical-grade TETA is sometimes available as a distillation cut that also contains branched isomers and cyclic compounds.

Reactivity Profile

Triethylenetetramine is a strong base; reacts violently with strong oxidants; attacks aluminum, zinc, copper and its alloys. Handling Chemicals Safely 198. p. 934).

Health Hazard

Vapors from hot liquid can irritate eyes and upper respiratory system. Liquid burns eyes and skin. May cause sensitization of skin.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Flammability and Explosibility

Non flammable

Contact allergens

Triethylenetetramine is used as an amine hardener in epoxy resins of the bisphenol A type. Cross-sensitivity is possible with diethylenetriamine and diethylenediamine.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and skin contact. An experimental teratogen. Experimental reproductive effects. Mutation data reported. A corrosive irritant to skin, eyes, and mucous membranes. Causes skin sensitization. Combustible when exposed to heat or flame. Ignites on contact with cellulose nitrate of high surface area. Can react with oxidizing materials. To fight fire, use CO2, dry chemical, alcohol foam. When heated to decomposition it emits toxic fumes of NOx.

Toxicology

Triethylenetetramine may induce lung edema on inhalation of its vapors. The compound is also an effective skin sensitizer. Following repeated dosing (ca. 50 mg each, 17 – 55 times) onto the skin of pregnant and nonpregnant guinea pigs, significant amounts were absorbed by the strongly irritated skin, leading to toxic effects in the kidneys, liver, brain, and placenta and causing abortion. Triethylenetetramine proved to be a mutagen in vitro but not in vivo.

Carcinogenicity

TETA was mutagenic in bacterial assays and was positive in sister chromatid exchanges and unscheduled DNA synthesis tests in vitro.8 It was not clastogenic in the mouse micronucleus test in vivo after oral or intraperitoneal administration.

Purification Methods

Dry the amine with sodium, then distil it under a vacuum. Further purification has been via the nitrate or the chloride salts. For example, Jonassen and Strickland [J Am Chem Soc 80 312 1958] separated TRIEN from admixture with TREN (38%) by solution in EtOH, cooling to approximately 5o in an ice-bath and adding conc HCl dropwise from a burette, keeping the temperature below 10o, until all of the white crystalline precipitate of TREN.HCl (see p 191) had formed and was removed. Further addition of HCl then precipitated thick, creamy white TRIEN.HCl (see below) which was crystallised several times from hot water by adding an excess of cold EtOH. The crystals were finally washed with Me2CO, then Et2O and dried in a vacuum desiccator. [Beilstein 4 H 255, 4 II 695, 4 III 542, 4 IV 1242.]

Triethylenetetramine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Ethylenediamine Diethylenetriamine 1,2-Dichloroethane Polyethylene-polyamines Dichloroethane 1,4,7,10,13-Pentaazatridecane

Preparation Products

1,1,4,7,10,10-HEXAMETHYLTRIETHYLENETETRAMINE Triethylenetetramine Dihydrochloride Diethylenetriamine triethylene tetraamine hexamethylene phosphoric acid TRIETHYLENETETRAMINE TETRAHYDROCHLORIDE Triethylenediamine
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View Lastest Price from Triethylenetetramine manufacturers

Sinoway Industrial co., ltd.
Product
Trientine 112-24-3
Min. Order
10Kg/Bag
Purity
0.99
Supply Ability
10 tons
Release date
2023-12-01
Hebei Weibang Biotechnology Co., Ltd
Product
Triethylenetetramine 112-24-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-31
Qingdao RENAS Polymer Material Co., Ltd.
Product
Triethylenetetramine 112-24-3
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2024-08-29

112-24-3, TriethylenetetramineRelated Search:

2-(2-Aminoethylamino)ethanol N-(1-Naphthyl)ethylenediamine dihydrochloride Polyamine N7 Tetraethylammonium bromide Diethylenetriaminepentaacetic acid Isophorondiamine Ethylenediamine dihydrochloride Diethylenetriamine Benzyltriethylammonium chloride HYDRAZINE Triethoxyvinylsilane ETHYLENE N,N-Diisopropylethylamine Tetraethylammonium hydroxide Styrene N,N,N',N'-Tetramethylethylenediamine Ethylenediamine Triethylenediamine

  • N,N'-DI(2-AMINOETHYL)ETHYLENEDIAMINE
  • N,N'-BIS(2-AMINOETHYL)ETHYLENEDIAMINE
  • Ethylenediamine, N,N'-bis(2-aminoethyl)-
  • hy951
  • n,n’-bis(2-aminoethyl)-2-ethanediamine
  • N,N’-bis-(2-amino-ethyl)-ethane-1,2-diamine
  • n,n’-bis(2-aminoethyl)-ethylenediamin
  • N,N'-Bis(2-aminoethyl)-1,2-diaminoethane
  • n,n-bis(2-aminoethyl)-1,2-diaminoethane
  • N1-[2-(2-Amino-ethylamino)-ethyl]-ethane-1,2-diamine
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  • triethylentetramine
  • n,n'-bis(2-aminoethyl)-1,2-ethanediamine
  • 3,6-DIAZAOCTANE-1,8-DIAMINE
  • 1,8-diamino-3,6-diazaoctane
  • 1,4,7,10-TETRAAZADECANE
  • Trientine
  • TRIEN
  • TRIETHYLENETETRAMINE
  • 1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-
  • 1,2-Ethanediamine,N,N’-bis(2-aminoethyl)-
  • 2-Ethanediamine,N,N’-bis(2-aminoethyl)-1
  • 3,6-Diazaoctanethylenediamin
  • Araldite Hardener HY 951
  • Araldite HY 951
  • aralditehardenerhy951
  • aralditehy951
  • DEH 24
  • deh24
  • Ethanediamine, N,N'-bis(2-aminoethyl)-
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  • TriethyleneTetramineForSynthesis
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  • Triethylentetramin
  • TRIETHYLENETETRAMINE: TECH., 60%, BALANCE BRANCHED AND CYCLIC TRIETHYLENETETRAMINES
  • LABOTEST-BB LTBB000434
  • N，N′-Bis(2-aminoethyl)thylenediamine
  • TRIETHYLENETETRAMINE (TETA)
  • Triethylenetetramine,95%