1-(2-Hydroxyethyl)-4-methylpiperazine

Product Name: 1-(2-Hydroxyethyl)-4-methylpiperazine
CAS No.: 5464-12-0
Chemical Name: 1-(2-Hydroxyethyl)-4-methylpiperazine
Synonyms: 4-Methylpiperazine-1-ethanol;4-Methyl-1-piperazineethanol;1-[N-Methylpiperazine]ethanol;2-(4-methylpiperazinyl)ethanol;1-piperazineethanol, 4-methyl-;4-Methylpiperazine-1-ethanol>2-(4-Methyl-1-piperazinyl)ethanol;2-(4-METHYLPIPERAZIN-1-YL)ETHANOL;1-hydroxyethyl-4-methylpiperazine;1-(2-Hydroxyethyl)-4-methyl-piper
CBNumber: CB8187583
Molecular Formula: C7H16N2O
Formula Weight: 144.21
MOL File: 5464-12-0.mol

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1-(2-Hydroxyethyl)-4-methylpiperazine Property

Melting point:: 39-41°C
Boiling point:: 54-55°C/0.5mbar
Density: 1.003±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
pka: 14.96±0.10(Predicted)
form: Low Melting Solid
color: Slightly yellow
InChI: InChI=1S/C7H16N2O/c1-8-2-4-9(5-3-8)6-7-10/h10H,2-7H2,1H3
InChIKey: QHTUMQYGZQYEOZ-UHFFFAOYSA-N
SMILES: N1(CCO)CCN(C)CC1
CAS DataBase Reference: 5464-12-0(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36/37/39-24/25-23
Hazard Note: Harmful
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2499
Product name: 4-Methylpiperazine-1-ethanol
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: M2499
Product name: 4-Methylpiperazine-1-ethanol
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $117
Updated: 2025/07/31

TRC

Product number: H949523
Product name: 1-(2-Hydroxyethyl)-4-methylpiperazine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: H949523
Product name: 1-(2-Hydroxyethyl)-4-methylpiperazine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Oakwood

Product number: 021290
Product name: 1-(2-Hydroxyethyl)-4-methylpiperazine
Packaging: 1g
Price: $10
Updated: 2021/12/16

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1-(2-Hydroxyethyl)-4-methylpiperazine Chemical Properties,Usage,Production

Chemical Properties

slightly yellow low melting solid

Synthesis

109-01-3

540-51-2

5464-12-0

The general procedure for the synthesis of 1-(2-hydroxyethyl)-4-methylpiperazine from N-methylpiperazine and 2-bromoethanol was as follows: 2-bromoethanol (2.36 g, 19 mmol) was added slowly and dropwise to a reaction flask containing a mixture of anhydrous ethanol (150 μL) with 1-methylpiperazine (1.26 g, 13 mmol) and potassium carbonate (5.0 g, 36 mmol). The reaction mixture was heated under reflux conditions for 18 hours. Upon completion of the reaction, the mixture was allowed to cool to room temperature and filtered to remove the insoluble precipitate. Subsequently, the solvent was removed by rotary evaporation. The residue was treated with a solvent mixture of acetone/dichloromethane (v/v ratio not specified), filtered again to remove the insoluble material, and finally the solvent was removed by rotary evaporation to afford 1-(2-hydroxyethyl)-4-methylpiperazine (870 mg, 48% yield) as a light brown oil. The product was confirmed by 1H NMR (CDCl3): δ 2.18 (s, 3H); 2.3-2.7 (br m, 8H); 2.56 (t, 2H); 3.61 (t, 2H).MS-ESI showed a molecular ion peak of 145 [MH]+.

References

[1] Patent: WO2004/7498, 2004, A2. Location in patent: Page 29
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 7, p. 622 - 626
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 14, p. 6305 - 6320
[4] Patent: US6291455, 2001, B1
[5] Patent: US2003/225111, 2003, A1. Location in patent: Page 41

1-(2-Hydroxyethyl)-4-methylpiperazine Preparation Products And Raw materials

Raw materials

Formaldehyde Formic acid 1-(2-Hydroxyethyl)piperazine

Preparation Products

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1-(2-Hydroxyethyl)-4-methylpiperazine Suppliers

Americas 1 Belgium 1 China 157 Europe 1 France 1 Germany 4 India 2 Japan 1 Switzerland 1 United Kingdom 11 United States 30 Global 210

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View Lastest Price from 1-(2-Hydroxyethyl)-4-methylpiperazine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-(2-Hydroxyethyl)-4-methylpiperazine 5464-12-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 1-(2-Hydroxyethyl)-4-methylpiperazine 5464-12-0
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-07

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5464-12-0

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