ChemicalBook > CAS DataBase List > 3-CHLORO-2-FLUOROPHENYLBORONIC ACID

3-CHLORO-2-FLUOROPHENYLBORONIC ACID

Product Name
3-CHLORO-2-FLUOROPHENYLBORONIC ACID
CAS No.
352535-82-1
Chemical Name
3-CHLORO-2-FLUOROPHENYLBORONIC ACID
Synonyms
Te4052;3-Chloro-2-fluorophenylboronic aci;2-Fluoro-3-chlorophenylboronic acid;3-CHLORO-2-FLUOROPHENYLBORONIC ACID;3-CHLORO-2-FLUOROBENZENEBORONIC ACID;Boronic acid, B-(3-chloro-2-fluorophenyl)-;3-CHLORO-2-FLUOROBENZENEBORONIC ACID; 3-CHLORO-2-FLUOROPHENYLBORONIC ACID;3-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride);3-Chloro-2-fluorobenzeneboronic Acid (contains varying amounts of Anhydride)
CBNumber
CB8189017
Molecular Formula
C6H5BClFO2
Formula Weight
174.37
MOL File
352535-82-1.mol
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3-CHLORO-2-FLUOROPHENYLBORONIC ACID Property

Melting point:
223 °C (dec.)(lit.)
Boiling point:
315.1±52.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
pka
7.35±0.58(Predicted)
form 
powder to crystal
color 
White to Almost white
Water Solubility 
Insoluble in water. Soluble in organic solvents.
CAS DataBase Reference
352535-82-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
WGK Germany 
3
Hazard Note 
Irritant/Keep Cold
HS Code 
2931900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2946
Product name
3-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
1g
Price
$41
Updated
2025/07/31
TCI Chemical
Product number
C2946
Product name
3-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$135
Updated
2025/07/31
TRC
Product number
C584615
Product name
3-Chloro-2-fluorophenylboronic acid
Packaging
100mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
PC9594
Product name
3-Chloro-2-fluorobenzeneboronicacid
Packaging
1g
Price
$10
Updated
2021/12/16
Oakwood
Product number
024874
Product name
3-Chloro-2-fluorobenzeneboronicacid
Purity
97%
Packaging
1g
Price
$10
Updated
2021/12/16
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3-CHLORO-2-FLUOROPHENYLBORONIC ACID Chemical Properties,Usage,Production

Uses

3-Chloro-2-fluorobenzeneboronic acid, Is used inorganic synthesis, catalysis, analytical chemistry and biological systems.

Synthesis

144584-65-6

352535-82-1

The general procedure for the synthesis of 3-chloro-2-fluorophenylboronic acid from 3-chloro-2-fluorobromobenzene was as follows: 16 g (72 mmol) of 1-bromo-3-chloro-2-fluorobenzene was added to a 500 mL three-necked flask and the air in the flask was displaced with nitrogen. Subsequently, 200 mL of tetrahydrofuran was added and the solution was cooled to -80 °C under a stream of nitrogen. 48 mL (76 mmol) of n-butyllithium (1.6 mol/L hexane solution) was slowly added dropwise with a syringe to this cooled solution, and after the dropwise addition was completed, the reaction mixture was continued to be stirred at the same temperature for 1.5 hours. After that, 9.0 mL (80 mmol) of trimethyl borate was added to the reaction mixture and gradually warmed up to room temperature (20 °C), where stirring was continued for about 19 hours. Upon completion of the reaction, about 100 mL of 1 mol/L hydrochloric acid was added to the resulting solution and the mixture was stirred. The organic layer was separated, washed with water, and the aqueous layer was extracted twice with toluene. The organic layer and the toluene extract were combined and washed with saturated aqueous sodium chloride solution. The combined organic layers were dried with anhydrous magnesium sulfate followed by gravity filtration. The filtrate was concentrated to give 4.5 g of the light yellow solid product 3-chloro-2-fluorophenylboronic acid in 35% yield.

References

[1] Patent: WO2014/69613, 2014, A1. Location in patent: Paragraph 0274; 0275; 0276
[2] Patent: WO2015/29796, 2015, A1

3-CHLORO-2-FLUOROPHENYLBORONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-CHLORO-2-FLUOROPHENYLBORONIC ACID manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
(3-Chloro-2-fluorophenyl)boronic acid 352535-82-1
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%min
Supply Ability
1000kg
Release date
2025-06-13
Career Henan Chemical Co
Product
3-CHLORO-2-FLUOROPHENYLBORONIC ACID 352535-82-1
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-20

352535-82-1, 3-CHLORO-2-FLUOROPHENYLBORONIC ACIDRelated Search:

3-CHLORO-4-FLUOROPHENYLBORONIC ACID,3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) 3-CHLORO-5-FLUOROPHENYLBORONIC ACID 4-CHLORO-2-FLUOROPHENYLBORONIC ACID 2-CHLORO-6-FLUOROPHENYLBORONIC ACID 3-(Benzyloxy)-2-chloro-6-fluorophenylboronic acid,3-Benzyloxy-2-chloro-6-fluorophenylboronic acid 5-CHLORO-2-FLUOROPHENYLBORONIC ACID 2-CHLORO-4-FLUOROPHENYLBORONIC ACID 2-CHLORO-5-FLUOROPHENYLBORONIC ACID 2-CHLORO-3-FLUOROPHENYLBORONIC ACID 4-CHLORO-3-FLUOROPHENYLBORONIC ACID,4-CHLORO-3-FLUOROPHENYLBORONIC ACID 98% 5-Bromo-3-chloro-2-fluorophenylboronic acid 3-CHLORO-2-FLUOROPHENYLBORONIC ACID 2-(3-Chloro-2-fluorophenyl)-4,4,6-trimethyl-1,3,2-dioxaborinane 2-(3-Chloro-2-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane 3-CHLORO-2,6-DIFLUOROPHENYLBORONIC ACID 6-Bromo-3-chloro-2-fluorophenylboronic acid

  • 3-CHLORO-2-FLUOROBENZENEBORONIC ACID
  • 3-CHLORO-2-FLUOROPHENYLBORONIC ACID
  • 2-Fluoro-3-chlorophenylboronic acid
  • 3-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)
  • 3-Chloro-2-fluorobenzeneboronic Acid (contains varying amounts of Anhydride)
  • Te4052
  • 3-Chloro-2-fluorophenylboronic aci
  • 3-CHLORO-2-FLUOROBENZENEBORONIC ACID; 3-CHLORO-2-FLUOROPHENYLBORONIC ACID
  • Boronic acid, B-(3-chloro-2-fluorophenyl)-
  • 352535-82-1
  • Organometallic Reagents
  • Aryl
  • Boronic Acids and Derivatives
  • Boronic Acids
  • Aryl
  • Boronic Acids
  • Boronic Acids and Derivatives
  • blocks
  • BoronicAcids
  • FluoroCompounds