3-CHLORO-2-FLUOROPHENYLBORONIC ACID
- Product Name
- 3-CHLORO-2-FLUOROPHENYLBORONIC ACID
- CAS No.
- 352535-82-1
- Chemical Name
- 3-CHLORO-2-FLUOROPHENYLBORONIC ACID
- Synonyms
- Te4052;3-Chloro-2-fluorophenylboronic aci;2-Fluoro-3-chlorophenylboronic acid;3-CHLORO-2-FLUOROPHENYLBORONIC ACID;3-CHLORO-2-FLUOROBENZENEBORONIC ACID;Boronic acid, B-(3-chloro-2-fluorophenyl)-;3-CHLORO-2-FLUOROBENZENEBORONIC ACID; 3-CHLORO-2-FLUOROPHENYLBORONIC ACID;3-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride);3-Chloro-2-fluorobenzeneboronic Acid (contains varying amounts of Anhydride)
- CBNumber
- CB8189017
- Molecular Formula
- C6H5BClFO2
- Formula Weight
- 174.37
- MOL File
- 352535-82-1.mol
3-CHLORO-2-FLUOROPHENYLBORONIC ACID Property
- Melting point:
- 223 °C (dec.)(lit.)
- Boiling point:
- 315.1±52.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- pka
- 7.35±0.58(Predicted)
- form
- powder to crystal
- color
- White to Almost white
- Water Solubility
- Insoluble in water. Soluble in organic solvents.
- CAS DataBase Reference
- 352535-82-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- WGK Germany
- 3
- Hazard Note
- Irritant/Keep Cold
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C2946
- Product name
- 3-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $41
- Updated
- 2025/07/31
- Product number
- C2946
- Product name
- 3-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $135
- Updated
- 2025/07/31
- Product number
- C584615
- Product name
- 3-Chloro-2-fluorophenylboronic acid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC9594
- Product name
- 3-Chloro-2-fluorobenzeneboronicacid
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 024874
- Product name
- 3-Chloro-2-fluorobenzeneboronicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
3-CHLORO-2-FLUOROPHENYLBORONIC ACID Chemical Properties,Usage,Production
Uses
3-Chloro-2-fluorobenzeneboronic acid, Is used inorganic synthesis, catalysis, analytical chemistry and biological systems.
Synthesis
144584-65-6
352535-82-1
The general procedure for the synthesis of 3-chloro-2-fluorophenylboronic acid from 3-chloro-2-fluorobromobenzene was as follows: 16 g (72 mmol) of 1-bromo-3-chloro-2-fluorobenzene was added to a 500 mL three-necked flask and the air in the flask was displaced with nitrogen. Subsequently, 200 mL of tetrahydrofuran was added and the solution was cooled to -80 °C under a stream of nitrogen. 48 mL (76 mmol) of n-butyllithium (1.6 mol/L hexane solution) was slowly added dropwise with a syringe to this cooled solution, and after the dropwise addition was completed, the reaction mixture was continued to be stirred at the same temperature for 1.5 hours. After that, 9.0 mL (80 mmol) of trimethyl borate was added to the reaction mixture and gradually warmed up to room temperature (20 °C), where stirring was continued for about 19 hours. Upon completion of the reaction, about 100 mL of 1 mol/L hydrochloric acid was added to the resulting solution and the mixture was stirred. The organic layer was separated, washed with water, and the aqueous layer was extracted twice with toluene. The organic layer and the toluene extract were combined and washed with saturated aqueous sodium chloride solution. The combined organic layers were dried with anhydrous magnesium sulfate followed by gravity filtration. The filtrate was concentrated to give 4.5 g of the light yellow solid product 3-chloro-2-fluorophenylboronic acid in 35% yield.
References
[1] Patent: WO2014/69613, 2014, A1. Location in patent: Paragraph 0274; 0275; 0276
[2] Patent: WO2015/29796, 2015, A1
3-CHLORO-2-FLUOROPHENYLBORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
3-CHLORO-2-FLUOROPHENYLBORONIC ACID Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from 3-CHLORO-2-FLUOROPHENYLBORONIC ACID manufacturers
- Product
- (3-Chloro-2-fluorophenyl)boronic acid 352535-82-1
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 1000kg
- Release date
- 2025-06-13
- Product
- 3-CHLORO-2-FLUOROPHENYLBORONIC ACID 352535-82-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-20