BOC-D-TIC-OH
Uses- Product Name
- BOC-D-TIC-OH
- CAS No.
- 115962-35-1
- Chemical Name
- BOC-D-TIC-OH
- Synonyms
- BOC-D-TIC;BOC-(3R)-1;(R)-N-BOC-1;BOC-D-TIC-OH;Boc-D-Tic-Ooh;RARECHEM BK PT 0080;Boc-
D -Tic-OH;BOC-D-TIC-OH USP/EP/BP;N-t-Butyloxycarbonyl-D-1;(Tert-Butoxy)Carbonyl D-Tic-OH - CBNumber
- CB8191993
- Molecular Formula
- C15H19NO4
- Formula Weight
- 277.32
- MOL File
- 115962-35-1.mol
BOC-D-TIC-OH Property
- Melting point:
- 122-123℃
- Boiling point:
- 420.18°C (rough estimate)
- Density
- 1.1311 (rough estimate)
- refractive index
- 1.5080 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 3.88±0.20(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 115962-35-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 15046
- Product name
- Boc-D-Tic-OH
- Purity
- ≥97%
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- B658953
- Product name
- BOC-D-TIC-OH
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- J94578
- Product name
- Boc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylicacid
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 02600
- Product name
- Boc-(3)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
- Purity
- ≥ 98% (HPLC)
- Packaging
- 1G
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 041824
- Product name
- Boc-(R)-1,2,3,4-tetrahydroisoquino-line-3-carboxylic acid
- Packaging
- 1g
- Price
- $37
- Updated
- 2021/12/16
BOC-D-TIC-OH Chemical Properties,Usage,Production
Uses
BOC-D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid can be used as an organic synthesis intermediate. It can be obtained by protecting (3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride with Boc, or by reacting L-Phe with aqueous formaldehyde solution and tert-butoxyanhydride.
Chemical Properties
white to light beige powder
Synthesis
24424-99-5
74163-81-8
115962-35-1
The general procedure for the synthesis of (R)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid from di-tert-butyl dicarbonate and (S)-(-)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid was as follows: (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (50.0 g, 282 mmol) was suspended in 1,4-dioxane ( 1000 mL) and water (500 mL) in a solvent mixture with vigorous stirring. Subsequently, sodium bicarbonate (47.4 g, 564 mmol) and di-tert-butyl dicarbonate (67.7 g, 310 mmol) were added and the reaction mixture was stirred continuously at room temperature for 6 days. After completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The concentrated residue was dissolved in water (2000 mL) and acidified by adding 30% w/v aqueous sodium bisulfate monohydrate (300 mL). The acidified aqueous phase was extracted with chloroform (3 x 1000 mL) and the organic phases were combined. The organic phases were sequentially washed with saturated saline, dried over anhydrous sodium sulfate, and subsequently concentrated under reduced pressure to afford the target product (R)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (90.0 g, quantitative yield) as a thick slurry. The product was confirmed by LCMS analysis: retention time (RT) 3.64 min; mass spectral data: m/z 178.1 [M-Boc + 2H]+; m/z 276.1 [M-H]-.
References
[1] Patent: WO2017/153513, 2017, A1. Location in patent: Page/Page column 78
[2] Patent: WO2017/153515, 2017, A1. Location in patent: Page/Page column 62
[3] Patent: WO2017/153520, 2017, A1. Location in patent: Page/Page column 44; 47
[4] Patent: WO2017/153519, 2017, A1. Location in patent: Page/Page column 56; 59
[5] Tetrahedron Letters, 2001, vol. 42, # 43, p. 7559 - 7561
BOC-D-TIC-OH Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BOC-D-TIC-OH manufacturers
- Product
- BOC-D-TIC-OH 115962-35-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12
- Product
- BOC-D-TIC-OH 115962-35-1
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- >98%
- Supply Ability
- g/kg/Ton
- Release date
- 2020-01-14