ChemicalBook > CAS DataBase List > 2-CHLORO-3-FLUOROBENZOIC ACID

2-CHLORO-3-FLUOROBENZOIC ACID

Product Name
2-CHLORO-3-FLUOROBENZOIC ACID
CAS No.
102940-86-3
Chemical Name
2-CHLORO-3-FLUOROBENZOIC ACID
Synonyms
CAS:102940-86-3;BUTTPARK 19\01-64;2-Chloro-3-Fluorobenzoic;2-CHLORO-3-FLUOROBENZOIC ACID;Benzoic acid,2-chloro-3-fluoro-;2-Chloro-3-fluorobenzoic Acid >
CBNumber
CB8194727
Molecular Formula
C7H4ClFO2
Formula Weight
174.56
MOL File
102940-86-3.mol
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2-CHLORO-3-FLUOROBENZOIC ACID Property

Melting point:
171 °C
Boiling point:
279.5±20.0 °C(Predicted)
Density 
1.477±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
2.56±0.25(Predicted)
color 
White to Almost white
CAS DataBase Reference
102940-86-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39-37
HazardClass 
IRRITANT
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2128
Product name
2-Chloro-3-fluorobenzoic Acid
Purity
>97.0%(GC)(T)
Packaging
1g
Price
$27
Updated
2025/07/31
TCI Chemical
Product number
C2128
Product name
2-Chloro-3-fluorobenzoic Acid
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$80
Updated
2025/07/31
TRC
Product number
C364830
Product name
2-Chloro-3-fluorobenzoic Acid
Packaging
25g
Price
$385
Updated
2021/12/16
Matrix Scientific
Product number
002345
Product name
2-Chloro-3-fluorobenzoic acid
Purity
95%
Packaging
1g
Price
$9
Updated
2021/12/16
Oakwood
Product number
005185
Product name
2-Chloro-3-fluorobenzoic Acid
Purity
98%
Packaging
1g
Price
$10
Updated
2021/12/16
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2-CHLORO-3-FLUOROBENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

2-Chloro-3-fluorobenzoic Acid is a useful synthetic intermediate. It can be used to synthesize aminobenzhydrol derivatives containing pendant cyclic amines as inhibitors of squalene synthase and cholesterol synthase. It can also be used to prepare aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists.

Synthesis

455-38-9

102940-86-3

General procedure for the synthesis of 2-chloro-3-fluorobenzoic acid from m-fluorobenzoic acid: 1. 3-Fluorobenzoic acid (4.02 g, 28.71 mmol) was dissolved in 20 mL of tetrahydrofuran (THF) to prepare a solution. 2. the above solution was slowly added dropwise to a suspension containing tetramethylene diamine (TMEDA) (10.00 mL, 66.3 mmol) and 1.3 M sec-butyllithium (sec-BuLi) (48 mL, 62.4 mmol) at -90 °C. the solution was then dissolved in 20 mL of tetrahydrofuran (THF) to form a solution. 3. 50 mL of THF was added to dilute the reaction mixture, maintaining the temperature at -90°C with continuous stirring for 35 minutes. 4. The reaction mixture was slowly warmed to -78°C followed by the addition of a solution of hexachloroethane (27.0 g, 113.9 mmol) in 50 mL of THF. 5. After the reaction had proceeded for 20 h, the reaction was quenched with water and the reaction mixture was diluted with ether. 6. The pH of the reaction mixture was adjusted to 1-2 using concentrated hydrochloric acid (HCl) to promote stratification. 7. The organic layer was separated, washed sequentially with water and brine, then dried and concentrated to give 30.4 g of crude product (tan solid). 8. The crude product was washed with hexane to yield 3.728 g (74% yield) of the target product 2-chloro-3-fluorobenzoic acid (1a) as a light tan solid. Mass spectrometry (MS) analysis showed m/z 175.2 (M + H).

References

[1] Patent: WO2004/39775, 2004, A2. Location in patent: Page 12
[2] Patent: WO2009/39091, 2009, A1. Location in patent: Page/Page column 13
[3] Patent: WO2007/150015, 2007, A2. Location in patent: Page/Page column 5
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995, # 10, p. 1265 - 1272
[5] Bulletin de la Societe Chimique de France, 1996, vol. 133, # 2, p. 133 - 141

2-CHLORO-3-FLUOROBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-3-FLUOROBENZOIC ACID Suppliers

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View Lastest Price from 2-CHLORO-3-FLUOROBENZOIC ACID manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-CHLORO-3-FLUOROBENZOIC ACID 102940-86-3
Price
US $10.00-8.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-06
Speranza Chemical Co., Ltd.
Product
2-Chloro-3-fluorobenzoic acid 102940-86-3
Price
US $410.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
300MT/year
Release date
2019-12-24
Shaanxi Dideu Medichem Co. Ltd
Product
2-CHLORO-3-FLUOROBENZOIC ACID 102940-86-3
Price
US $0.10/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
2000TONS
Release date
2019-12-24

102940-86-3, 2-CHLORO-3-FLUOROBENZOIC ACIDRelated Search:

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  • 2-CHLORO-3-FLUOROBENZOIC ACID
  • BUTTPARK 19\01-64
  • 2-Chloro-3-Fluorobenzoic
  • Benzoic acid,2-chloro-3-fluoro-
  • 2-Chloro-3-fluorobenzoic Acid &gt
  • CAS:102940-86-3
  • 102940-86-3
  • Fluorine series
  • FINE Chemical & INTERMEDIATES
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts