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Sodium dihydrogen phosphate dihydrate

Description References
Product Name
Sodium dihydrogen phosphate dihydrate
CAS No.
13472-35-0
Chemical Name
Sodium dihydrogen phosphate dihydrate
Synonyms
Sodium dihydrogen orthophosphate;SODIUM BIPHOSPHATE;SODIUM PHOSPHATE, MONOBASIC, DIHYDRATE;SODIUM PHOSPHATE DIHYDRATE;SAMARIUM 1,000PPM;99.0 ~ 101.0%，ACS;Sodium dihydrogen ph;Natriumdihydrogenphosphat;SODIUM PHOSPHATE 1BAS 2HYD;MONO-SODIUM ORTHOPHOSPHATE
CBNumber
CB8203308
Molecular Formula
NaH2PO4·2H2O
Formula Weight
140.01
MOL File
13472-35-0.mol
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Sodium dihydrogen phosphate dihydrate Property

Melting point:
60 °C
Density 
1,915 g/cm3
storage temp. 
Store at +5°C to +30°C.
solubility 
H2O: 1 M at 20 °C, clear, colorless
form 
Solid
color 
White
PH
4.0-4.5 (25℃, 50mg/mL in H2O)
Odor
Odorless
PH Range
4.2 - 4.5
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
λmax
λ: 260 nm Amax: 0.085
λ: 280 nm Amax: 0.070
Merck 
14,8660
Stability:
Stable.
InChIKey
VBJGJHBYWREJQD-UHFFFAOYSA-M
CAS DataBase Reference
13472-35-0(CAS DataBase Reference)
EPA Substance Registry System
Phosphoric acid, monosodium salt (13472-35-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36-36/37/38
Safety Statements 
39-26-24/25-36
WGK Germany 
1
RTECS 
WA1900500
TSCA 
Yes
HS Code 
2835 22 00
Toxicity
LD50 orally in Rabbit: 8290 mg/kg LD50 dermal Rabbit > 7940 mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1.37018
Product name
Sodium dihydrogen phosphate dihydrate
Purity
EMPROVE? EXPERT, Ph. Eur., BP, JPE, USP
Packaging
1KG
Price
$69
Updated
2024/03/01
Sigma-Aldrich
Product number
1.37018
Product name
Sodium dihydrogen phosphate dihydrate
Purity
EMPROVE? EXPERT, Ph. Eur., BP, JPE, USP
Packaging
5KG
Price
$132
Updated
2024/03/01
Sigma-Aldrich
Product number
1.37018
Product name
Sodium dihydrogen phosphate dihydrate
Purity
EMPROVE? EXPERT Ph Eur,BP,USP,JPE
Packaging
12kg
Price
$435
Updated
2024/03/01
Sigma-Aldrich
Product number
1.37018
Product name
Sodium dihydrogen phosphate dihydrate
Purity
EMPROVE? EXPERT Ph Eur,BP,USP,JPE
Packaging
25kg
Price
$556
Updated
2024/03/01
Sigma-Aldrich
Product number
1.06345
Product name
Sodium dihydrogen phosphate dihydrate
Purity
EMPROVE? ESSENTIAL Ph Eur,BP,USP,JPE,E 339
Packaging
1kg
Price
$37
Updated
2024/03/01
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Sodium dihydrogen phosphate dihydrate Chemical Properties,Usage,Production

Description

Sodium Dihydrogen Phosphate occurs as two forms: the crystal form (dihydrate) called Sodium Dihydrogen Phosphate (crystal) and anhydrous form called Sodium Dihydrogen Phosphate (anhydrous)
It is used as an acidity regulator and sequestrant in foods. It is used as a pH buffer (baking powders, fleet enema solution, electroplating baths, and acid cleaners), emulsifier, laboratory reagent, metal phosphating reagent, and textile dyeing/printing auxiliary. It is also used to treat boiled water and waste waster and to remove halogen from waste gases. Furthermore, it is used as a cattle feed supplement, as nutritional supplement in food, in dentrifice formulations, in vitreous enamel frits, for the synthesis of pharmaceuticals, and as a phosphate source for micro-organisms in effluent treatment.

References

[1] http://sydney.edu.au
[2] https://hazmap.nlm.nih.gov
[3] https://www.chemsupply.com.au

Chemical Properties

white crystalline solid

Chemical Properties

The USP 32 states that monobasic sodium phosphate contains one or two molecules of water of hydration or is anhydrous.
The hydrated forms of monobasic sodium phosphate occur as odorless, colorless or white, slightly deliquescent crystals. The anhydrous form occurs as a white crystalline powder or granules.

Uses

Sodium dihydrogen phosphate dihydrate acts as buffering capacity reagent in molecular biology, biochemistry and chromatography. It is used in the preparation of biological buffers. It is also used in the purification of antibodies, as a laxative and, in combination with other sodium phosphates.
Sodium phosphate monobasic dihydrate is a reagent with very high buffering capacity widely used in molecular biology, biochemistry and chromatography. Sodium phosphate dibasic is highly hygroscopic and water soluble.
Recommended chemicals for the preparation of phosphate buffers are sodium dihydrogen phosphate dihydrate，NaH2PO4.2H2O(mol. wt.156.0)，disodium hydrogen phosphate dihydrate，Na2HPO4.2H2O (mol. wt.178.0), and sodium hydroxide pellets.

Uses

Sodium dihydrogen phosphate dihydrate is typically used as a phosphate buffer system component for downstream biomolecule chromatography steps or final liquid formulation.
Due to its low microbial and endotoxin limits, Sodium dihydrogen phosphate dihydrate Emprove? Expert is especially suitable for high-risk applications.

Production Methods

Monobasic sodium phosphate is prepared by adding phosphoric acid to a hot, concentrated solution of disodium phosphate until the liquid ceases to form a precipitate with barium chloride. This solution is then concentrated and the monobasic sodium phosphate is crystallized.

Pharmaceutical Applications

Monobasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, monobasic sodium phosphate is used as a mild saline laxative and in the treatment of hypophosphatemia.
Monobasic sodium phosphate is also used in food products, for example, in baking powders, and as a dry acidulant and sequestrant.

Biochem/physiol Actions

Sodium phosphate monobasic also referred to as sodium dihydrogen phosphate is a chemical reagent possesses high buffering capacity and is used for preparing biological buffers. It was used as a phosphate supplement for determining whether phosphate supplementation can prevent rickets in very low birth weight infants with prenatal deficiency of phosphate.

Safety

Monobasic sodium phosphate is widely used as an excipient in parenteral, oral, and topical pharmaceutical formulations.
Phosphate occurs extensively in the body and is involved in many physiological processes since it is the principal anion of intracellular fluid. Most foods contain adequate amounts of phosphate, making hypophosphatemia virtually unknown except in certain disease states or in patients receiving total parenteral nutrition. Treatment is usually by the oral administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces. Excessive administration of phosphate, particularly intravenously, rectally, or in patients with renal failure, can cause hyperphosphatemia that may lead to hypocalcemia or other severe electrolyte imbalances. Adverse effects occur less frequently following oral consumption, although phosphates act as mild saline laxatives when administered orally or rectally (2–4 g of monobasic sodium phosphate in an aqueous solution is used as a laxative). Consequently, gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of monobasic sodium phosphate as an excipient in oral formulations. However, the level of monobasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.
LD50 (rat, IM): 0.25 g/kg(10)
LD50 (rat, oral): 8.29 g/kg

storage

Monobasic sodium phosphate is chemically stable, although it is slightly deliquescent. On heating at 100°C, the dihydrate loses all of its water of crystallization. On further heating, it melts with decomposition at 205℃, forming sodium hydrogen pyrophosphate, Na2H2P2O7. At 250℃ it leaves a final residue of sodium metaphosphate, NaPO3.
Aqueous solutions are stable and may be sterilized by autoclaving.
Monobasic sodium phosphate should be stored in an airtight container in a cool, dry place.

Incompatibilities

Monobasic sodium phosphate is an acid salt and is therefore generally incompatible with alkaline materials and carbonates; aqueous solutions of monobasic sodium phosphate are acidic and will cause carbonates to effervesce.
Monobasic sodium phosphate should not be administered concomitantly with aluminum, calcium, or magnesium salts since they bind phosphate and could impair its absorption from the gastrointestinal tract. Interaction between calcium and phosphate, leading to the formation of insoluble calcium phosphate precipitates, is possible in parenteral admixtures.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections; infusions; ophthalmic, oral, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Sodium dihydrogen phosphate dihydrate Preparation Products And Raw materials

Raw materials

Sodium carbonate

Preparation Products

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View Lastest Price from Sodium dihydrogen phosphate dihydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Sodium dihydrogen phosphate dihydrate 13472-35-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-16
Hebei Andu Technology Com.,Ltd
Product
Sodium Dihydrogen Phosphate 13472-35-0
Price
US $3.60/kg
Min. Order
1kg
Purity
≥99%
Supply Ability
3000tons/month
Release date
2024-08-18
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
MONOSODIUM PHOSPHATE DIHYDRATE 13472-35-0
Price
US $70.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-05-23

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