ChemicalBook > CAS DataBase List > Fmoc-Gly-Gly-OH

Fmoc-Gly-Gly-OH

Product Name
Fmoc-Gly-Gly-OH
CAS No.
35665-38-4
Chemical Name
Fmoc-Gly-Gly-OH
Synonyms
Fmoc-G-G;FMoc-Gly4;FMoc-Gly-Gly;FMOC-GLY-GLY-OH;FMOC-GLYCYL-GLYCINE;N-Fmoc-glycylglycine;N-Fmoc-L-glycylglycine;REF DUPL: Fmoc-Gly-Gly-OH;Fmoc-Gly-Gly-OH USP/EP/BP;N-Fmoc-L-glycylglycine，98%
CBNumber
CB8211408
Molecular Formula
C19H18N2O5
Formula Weight
354.36
MOL File
35665-38-4.mol
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Fmoc-Gly-Gly-OH Property

Melting point:
176-177 °C
Boiling point:
684.1±45.0 °C(Predicted)
Density 
1.338±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
pka
3.39±0.10(Predicted)
form 
Powder
color 
White
InChI
InChI=1S/C19H18N2O5/c22-17(20-10-18(23)24)9-21-19(25)26-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,20,22)(H,21,25)(H,23,24)
InChIKey
FBKUOPULLUJMOC-UHFFFAOYSA-N
SMILES
C(O)(=O)CNC(=O)CNC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
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Safety

HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

TCI Chemical
Product number
F1234
Product name
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycylglycine
Packaging
5G
Price
$42
Updated
2025/07/31
TCI Chemical
Product number
F1234
Product name
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycylglycine
Packaging
25G
Price
$164
Updated
2025/07/31
TRC
Product number
F620170
Product name
Fmoc-Gly-Gly-OH
Packaging
500mg
Price
$65
Updated
2021/12/16
Usbiological
Product number
277234
Product name
Fmoc-Gly-Gly-OH
Packaging
1g
Price
$372
Updated
2021/12/16
BroadPharm
Product number
BP-25472
Product name
Mal-Cyclohexyl-PEG3-Biotin
Purity
98%
Packaging
25g
Price
$380
Updated
2021/12/16
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Fmoc-Gly-Gly-OH Chemical Properties,Usage,Production

Description

Fmoc-Gly-Gly-OH is a peptide linker. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations.

Chemical Properties

White powder

Uses

Fmoc-Gly-Gly-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Synthesis

556-50-3

28920-43-6

35665-38-4

General procedure for the synthesis of N-fluorenylmethoxycarbonyl-glycyl-glycine from bisglycopeptide and chloroformic acid-9-fluorenylmethyl ester: 15 mL of dioxane was added to a mixture of bisglycopeptide (1 mmol) and chloroformic acid-9-fluorenylmethyl ester (1.2 mmol), cooled to 0 °C and then an equal volume of a 1N Na2CO3 solution was slowly added. The reaction mixture was stirred at room temperature for 12 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction solution was acidified to pH 4-5 with 1 M HCl. The reaction mixture was extracted with ethyl acetate (3 x 70 mL) at 0 °C. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford pure N-fluorenylmethoxycarbonyl-glycyl-glycine in 89% yield.

IC 50

Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Fmoc-Gly-Gly-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-Gly-Gly-OH Suppliers

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View Lastest Price from Fmoc-Gly-Gly-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-Gly-Gly-OH 35665-38-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-02-04
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Fmoc-Gly-Gly-OH 35665-38-4
Price
US $80.00-800.00/KG
Min. Order
10KG
Purity
0.99
Supply Ability
20tons
Release date
2023-10-27
Xian confluore Biological Technology Co., Ltd.
Product
Fmoc-Gly-Gly-OH 35665-38-4
Price
US $0.00/g
Min. Order
500g
Purity
>95.00%
Supply Ability
500g
Release date
2024-04-01

35665-38-4, Fmoc-Gly-Gly-OHRelated Search:

4-Hydroxy-D-(-)-2-phenylglycine Fmoc-Aib-OH 4-Aminophenylacetic acid Glycine N-Carbobenzyloxyglycine Glycylglycine 9-Fluorenylmethyl chloroformate METHOXYFENOZIDE Fmoc-Gly-OH Fmoc-OSu Fmoc FMOC-ALA-ALA-OH Fmoc-Pro-Pro-OH FMOC-LYS(BOC)-LEU-OH FMOC-ALA-PRO-OH FMOC-NLE-NLE-OH FMOC-SER(TBU)-THR(TBU)-OH FMOC-PHE-ARG-OH

  • N-9-Fluorenylmethoxycarbonylglycylglycine
  • FMOC-GLYCYL-GLYCINE
  • FMOC-GLY-GLY-OH
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycyl-glycine
  • 2-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)acetamido)acetic acid
  • REF DUPL: Fmoc-Gly-Gly-OH
  • FMoc-Gly-Gly
  • FMoc-Gly4
  • Fmoc-Gly-Gly-OH≥ 99% (HPLC)
  • N-Fmoc-L-glycylglycine
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Gly-Gly-OH
  • N-Fmoc-glycylglycine
  • (((9H-Fluoren-9-yl)methoxy)carbonyl)glycylglycine
  • [({[(9H-fluoren-9-ylmethoxy)carbonyl]amino}acetyl)amino]acetic acid
  • Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-
  • 2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetic acid
  • 2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]aceticaci
  • Fmoc-Gly-Gly-OH USP/EP/BP
  • N-Fluorene methoxycarbonyl-glycyl-glycine
  • N-Fmoc-L-glycylglycine, 97%
  • N-Fmoc-L-glycylglycine，98%
  • Fmoc-G-G
  • 35665-38-4
  • Amino Acid Derivatives
  • ADCs