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tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate

Product Name
tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate
CAS No.
414910-15-9
Chemical Name
tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate
Synonyms
Olapali impurity 9;Olaparib Impurity Z;Olapali impurity 21;Artemether Impurity 13;tert-Butyl 4-(cyclopropanecarbonyl);(4-Boc-1-piperazinyl)(cyclopropyl)methanone;ert-butyl4-(cyclopropanecarbonyl)piperazine-1-carboxylate;tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate;tert-butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate;4-Cyclopropanoylpiperazine-1-carboxylic acid tert-butyl ester
CBNumber
CB82122010
Molecular Formula
C13H22N2O3
Formula Weight
254.33
MOL File
414910-15-9.mol
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tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate Property

Boiling point:
388.4±35.0 °C(Predicted)
Density 
1.175±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
-0.25±0.70(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C991524
Product name
4-Cyclopropanoylpiperazine-1-carboxylicAcidtert-ButylEster
Packaging
100mg
Price
$70
Updated
2021/12/16
TRC
Product number
C991524
Product name
4-Cyclopropanoylpiperazine-1-carboxylicAcidtert-ButylEster
Packaging
250mg
Price
$140
Updated
2021/12/16
TRC
Product number
C991524
Product name
4-Cyclopropanoylpiperazine-1-carboxylicAcidtert-ButylEster
Packaging
500mg
Price
$235
Updated
2021/12/16
ChemScene
Product number
CS-M1240
Product name
tert-Butyl4-(cyclopropanecarbonyl)piperazine-1-carboxylate
Purity
99.23%
Packaging
10g
Price
$279
Updated
2021/12/16
AK Scientific
Product number
5714AB
Product name
tert-Butyl4-(cyclopropanecarbonyl)piperazine-1-carboxylate
Packaging
5g
Price
$788
Updated
2021/12/16
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tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate Chemical Properties,Usage,Production

Uses

4-Cyclopropanoylpiperazine-1-carboxylic Acid tert-Butyl Ester is a useful reagent for organic synthesis and other chemical processes. It is used as a reagent in the preparation of propanoyl-quinazolinone scaffold-based novel PARP1 inhibitors.

Synthesis

4023-34-1

57260-71-6

414910-15-9

S1: In a 20L four-necked flask equipped with a mechanical stirrer and a thermometer, N-Boc-piperazine (1.82 kg, 9.77 mol), triethylamine (1.48 kg, 14.66 mol), and dichloromethane (5.46 kg) were added, and the mixture was cooled to 0 °C. Cyclopropanecarbonyl chloride (1.12 kg, 10.75 mol) was slowly added dropwise while maintaining the temperature from 0 °C to 10 °C. After the dropwise addition was completed, the reaction mixture was stirred at 10°C to 20°C for 3 hours. After completion of the reaction, 5 kg of water was added and the pH was adjusted to 8-9 with sodium carbonate. the organic and aqueous phases were separated and the organic phase was collected. Extract again with 1.50kg of aqueous phase and combine all dichloromethane phases. The combined organic phases were washed sequentially with 2 kg of 0.05 M dilute hydrochloric acid and 2 kg of water. The dichloromethane phase was concentrated to give tert-butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate (2.43 kg, 98% yield). The NMR spectrum was consistent with the standard spectrum.

References

[1] Patent: CN108341792, 2018, A. Location in patent: Paragraph 0028; 0033
[2] Patent: US2010/35883, 2010, A1. Location in patent: Page/Page column 56
[3] Patent: WO2011/130661, 2011, A1. Location in patent: Page/Page column 102
[4] Patent: US2004/14770, 2004, A1. Location in patent: Page/Page column 11

tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate Suppliers

China 95 India 3 Russia 1 United States 6 Global 105
Aronis
Tel
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Fax
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Email
aronis@aronis.ru
Country
Russia
ProdList
6592
Advantage
60
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View Lastest Price from tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate manufacturers

Career Henan Chemical Co
Product
tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate 414910-15-9
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-20

414910-15-9, tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylateRelated Search:

tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate 2,2'-Oxybis(nitrobenzene) Olaparib Impurity 30 Olaparib Impurity 31 2-Propanone, 1-[4,5-dihydro-2-(4-methyl-1-piperazinyl)-4-thioxo-3H-1,5-benzodiazepin-3-ylidene]- Cyclopropanecarbonyl Chloride Olaparib Impurity 14 1-Hydroxybenzotriazole 1,1,3,3-Tetramethylurea 3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid Cyclopropanecarboxylic acid tert-Butyl 1-piperazinecarboxylate tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoyl)piperazine-1-carboxylate 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile 5-Bromo-2-fluorobenzonitrile 3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid 2-Bromopropane PIPERAZINE DIHYDROCHLORIDE

  • tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate
  • tert-butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate
  • 4-(cyclopropylcarbonyl)-1-Piperazinecarboxylic acid 1,1-dimethylethyl ester
  • 4-Cyclopropanoylpiperazine-1-carboxylic acid tert-butyl ester
  • tert-Butyl 4-(cyclopropanecarbonyl)
  • (4-Boc-1-piperazinyl)(cyclopropyl)methanone
  • 1-Piperazinecarboxylic acid, 4-(cyclopropylcarbonyl)-, 1,1-dimethylethyl ester
  • Olaparib Impurity Z
  • ert-butyl4-(cyclopropanecarbonyl)piperazine-1-carboxylate
  • Olapali impurity 9
  • 1,1-Dimethylethyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate
  • Artemether Impurity 13
  • tert-Butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate (Olaparib Impurity)
  • Olapali impurity 21
  • 414910-15-9