Bromfenac Sodium
- Product Name
- Bromfenac Sodium
- CAS No.
- 120638-55-3
- Chemical Name
- Bromfenac Sodium
- Synonyms
- Duract;Unii-8ecv571Y37;Bromfenac sodiu;Bromfenac sodium;Bromfenac ophthalmic;acetate hydrate(2:2:3);Bromfenac sodium hydrate;BroMfenac sodiuM 1.5H2O;Sodium bromfenate hydrate;Sodium bromofenac 15 hydrate
- CBNumber
- CB82130312
- Molecular Formula
- C15H11BrNNaO3
- Formula Weight
- 356.15
- MOL File
- 120638-55-3.mol
Bromfenac Sodium Property
- Melting point:
- 268-270°C (dec.)
- storage temp.
- Refrigerator
- solubility
- DMSO: ≥ 100 mg/mL (260.98 mM); Water: ≥ 100 mg/mL (260.98 mM)
- form
- Solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- B678550
- Product name
- BromfenacSodiumSesquihydrate
- Packaging
- 50mg
- Price
- $235
- Updated
- 2021/12/16
- Product number
- 098118
- Product name
- Sodium 2-(2-amino-3-(4-bromobenzoyl)-phenyl)acetate trihydrate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $315
- Updated
- 2021/12/16
- Product number
- CS-5737
- Product name
- Bromfenacsodiumhydrate
- Purity
- 99.70%
- Packaging
- 200mg
- Price
- $336
- Updated
- 2021/12/16
- Product number
- R722
- Product name
- Bromfenacmonosodiumsaltsesquihydrate
- Packaging
- 50mg
- Price
- $380
- Updated
- 2021/12/16
- Product number
- API0000432
- Product name
- BROMFENAC SODIUM
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $704.55
- Updated
- 2021/12/16
Bromfenac Sodium Chemical Properties,Usage,Production
Description
Duract was launched in the US as a potent, orally-active, long lasting peripheral analgesic with antiinflammatory properties. It is structurally similar to ketoprofen and diclofenac and can be prepared in three steps from 2-amino-4’-bromophenone using Gassman’s oxindole synthesis. Duract’s biological effects are a result of its ability to reduce prostaglandin production through inhibition of cyclooxygenase. As a 4-bromo derivative of Amfenac, this modification increased the duration of analgesic activity and antiinflammatory potency. It was also free of any CNS, cardiovascular or autonomic effects. In comparison, 5 mg of Duract was equipotent to 650 mg of ASA and 25 mg was slightly more potent than 400 mg of Ibuprofen.
Chemical Properties
Yellow Solid
Originator
American Home Products (US)
Uses
Bromfenac (Xibrom, ISTA Pharmaceuticals, Irvine, USA; Bronuck, Senju Pharmaceutical, Osaka, Japan) is indicated for the treatment of postoperative inflammation and the reduction of ocular pain in patients after undergoing cataract extraction. For this task, one drop of Xibrom may be applied to the affected eye twice daily beginning 24 hours after cataract surgery and continuing for the first 2 weeks of the postoperative period. The clinical safety and efficacy of bromfenac have been extensively studied in diverse comparative investigations, including the treatment of external or anterior ocular inflammatory diseases, allergic conjunctivitis, scleritis, and postoperative inflammation.The results of two phase III multicenter, randomized double-masked placebo-controlled clinical trials showed that bromfenac ophthalmic solution 0.09% was effective in the rapid resolution of ocular pain after cataract surgery, and there was a statistically significant difference between the bromfenac and placebo groups demonstrated in these phase III clinical trials.
Uses
Bromfenac is a non-steroidal anti-inflammatory agent.
Definition
ChEBI: The sesquihydrate of the sodium salt of bromfenac. It is used for the management of ocular pain and treatment of postoperative inflammation in patients who have undergone cataract extraction.
brand name
Xibrom (Ista).
Bromfenac Sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Bromfenac Sodium Suppliers
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View Lastest Price from Bromfenac Sodium manufacturers
- Product
- Bromfenac Sodium Sesquihydrate 120638-55-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-28
- Product
- Bromfenac Sodium 120638-55-3
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10
- Release date
- 2023-07-11
- Product
- Bromfenac Sodium 120638-55-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-01