Rosmanol

Product Name: Rosmanol
CAS No.: 80225-53-2
Chemical Name: Rosmanol
Synonyms: Rosmano;20-Deoxocarnosol;rat tail oxalic acid;rosemary antioxidant;Rosmanol,Inhibitor,inhibit;Keywords honeysuckle extract;6β,7α,11,12-Tetrahydroxyabieta-8,11,13-trien-20-oic acid 20,6-lactone;(4bR,8aS,9R,10S)-3,4,10-trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one;(4bR,8aS,9S,10S)-3,4,10-Trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one;(4aR,10aα)-1,3,4,9,10,10a-Hexahydro-5,6,9α-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-2H-10β,4aβ-(epoxymethano)phenanthren-12-one
CBNumber: CB82131157
Molecular Formula: C20H26O5
Formula Weight: 346.42
MOL File: 80225-53-2.mol

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Rosmanol Property

Melting point:: 212-213 °C(Solv: ethyl ether (60-29-7))
Boiling point:: 574.2±50.0 °C(Predicted)
Density: 1.33
storage temp.: 2-8°C
solubility: DMSO: soluble
form: A solid
pka: 9.07±0.60(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: R2999-90
Product name: Rosmarinic Acid
Packaging: 50mg
Price: $276
Updated: 2021/12/16

Usbiological

Product number: 300896
Product name: Rosmarinic acid
Packaging: 20mg
Price: $277
Updated: 2021/12/16

Usbiological

Product number: 020735
Product name: Rosmarinic Acid
Packaging: 5g
Price: $496
Updated: 2021/12/16

Usbiological

Product number: 256499
Product name: Rosmarinic acid
Packaging: 50mg
Price: $403
Updated: 2021/12/16

ChemScene

Product number: CS-0032078
Product name: Rosmanol
Purity: 97.02%
Packaging: 10mg
Price: $280
Updated: 2021/12/16

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Rosmanol Chemical Properties,Usage,Production

Anticancer Research

This is a polyphenol and an ester of caffeic acid and 3,4-dihydroxyphylllique acid.This is commonly found in Boraginaceae species and Nepettoideae, a Lamiaceaesubfamily. It plays an important role in anti-inflammatory, antitumor, andantiproliferation activities. It shows a dose-dependent inhibition of invasion,migration, and adhesion of LS-174-T human colon carcinoma cells. It inhibits thebone metastasis from breast cancer via NF-κB and its downward IL-8 pathway(Wang et al. 2012). It reduces ERK and COX-2 phosphorylation in colon carcinoma.It reduces the activity of DNA methyltransferase and interferes with RANKL/RANK/OPG networks in breast cancer cells. It targets NF-kB pathway in U938cells and PKA/CREB/MITF pathways in melanoma cells (Singh et al. 2016b). InU938 human leukemic cells, it sensitizes TNF-α-induced apoptosis by affectingNF-kB and ROS and inhibits the activation of NF-kB by inhibiting IκBαphosphorylation and degradation. It also reduces the levels of promoter activity ofCOX-2 protein induced by TPA in HT-29 colon cancer cells and antagonizes TPAstimulating effects on COX-2 expression (Petersen and Simmonds 2003).

Cytotoxicity

IC50 (μg/mL): 1.71 (A2780), 6.96(SW1573), 10.13 (WiDr), 10.13 (T-47D),1.46 (HBL-100) (Guerrero et al. 2006;Zhang et al. 2017)

Rosmanol Preparation Products And Raw materials

Raw materials

Preparation Products

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Rosmanol Suppliers

China 96 United Kingdom 1 United States 10 Global 107

Changsha Staherb Natural Ingredients Co., Ltd.

Tel: 0731-84213302 18374838656
Email: sales06@staherb.cn
Country: China
ProdList: 285
Advantage: 58

ChengDu YiRui Bio-Technology CO., LTD

Tel: 17345243906 18224028459
Fax: QQ137193152
Email: tangcongxin2020@163.com
Country: China
ProdList: 1203
Advantage: 58

Shandong Xiya Chemical Co., Ltd

Tel: 13355009207 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18739
Advantage: 57

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14059
Advantage: 65

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

Chengdu Herbpurify Co.Ltd.

Tel: 18302802153 18981717076
Fax: 086-28-85377358
Email: 2355253619@qq.com
Country: China
ProdList: 1104
Advantage: 58

Shanghai Zhanshu Chemical Technology Co., Ltd

Tel: +86-21-58589556
Fax: +86-21-58589557
Country: China
ProdList: 413
Advantage: 55

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15185
Advantage: 58

Microherb Inc.

Tel: +86 (744) 832-8128
Fax: QQ:2236179442; Skype:donviez
Email: sales@microherb.cn
Country: China
ProdList: 48
Advantage: 50

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View Lastest Price from Rosmanol manufacturers

Career Henan Chemical Co

Product: Rosmanol 80225-53-2
Price: US $8.00/KG
Min. Order: 1g
Purity: ＞98% HPLC
Supply Ability: kg--ton
Release date: 2020-02-20

80225-53-2, RosmanolRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate Glycine Citric acid Rosemary oil Rosmarinic acid Cryptotanshinone Rosemary Herb Extract Luteolin Salidroside Baicalin DL-Limonene SAGE OIL, SPANISH Caffeine Folic acid Ascoric Acid Rosemary Rosmanol phosphoric acid

[4aR-(4aa,9b,10a,10ab)]-1,3,4,9,10,10a-Hexahydro-5,6,9-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-2H-10,4a-(epoxymethano)phenanthren-12-one

(4aR,10aα)-1,3,4,9,10,10a-Hexahydro-5,6,9α-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-2H-10β,4aβ-(epoxymethano)phenanthren-12-one

20-Deoxocarnosol

6β,7α,11,12-Tetrahydroxyabieta-8,11,13-trien-20-oic acid 20,6-lactone

(4bR,8aS,9S,10S)-3,4,10-Trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one

(4bR,8aS,9R,10S)-3,4,10-trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one

Keywords honeysuckle extract

rat tail oxalic acid

2H-10,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6,9-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9S,10S,10aS)-

Rosmanol,Inhibitor,inhibit

Rosmano

rosemary antioxidant

80225-53-2

2023-92-5