Rosmanol

ChemicalBook > CAS DataBase List > Rosmanol

Product Name: Rosmanol
CAS No.: 80225-53-2
Chemical Name: Rosmanol
Synonyms: Rosmano;Rosmanol-RM;20-Deoxocarnosol;rat tail oxalic acid;rosemary antioxidant;Rosmanol,Inhibitor,inhibit;Keywords honeysuckle extract;6β,7α,11,12-Tetrahydroxyabieta-8,11,13-trien-20-oic acid 20,6-lactone;(4bR,8aS,9R,10S)-3,4,10-trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one;(4bR,8aS,9S,10S)-3,4,10-Trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one
CBNumber: CB82131157
Molecular Formula: C20H26O5
Formula Weight: 346.42
MOL File: 80225-53-2.mol

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Rosmanol Property

Melting point:: 212-213 °C(Solv: ethyl ether (60-29-7))
Boiling point:: 574.2±50.0 °C(Predicted)
Density: 1.33
storage temp.: 2-8°C
solubility: DMSO: soluble
form: A solid
pka: 9.07±0.60(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: R2999-90
Product name: Rosmarinic Acid
Packaging: 50mg
Price: $276
Updated: 2021/12/16

Usbiological

Product number: 300896
Product name: Rosmarinic acid
Packaging: 20mg
Price: $277
Updated: 2021/12/16

Usbiological

Product number: 256499
Product name: Rosmarinic acid
Packaging: 50mg
Price: $403
Updated: 2021/12/16

Usbiological

Product number: 020735
Product name: Rosmarinic Acid
Packaging: 5g
Price: $496
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FR167087
Product name: Rosmanol
Packaging: 1mg
Price: $60
Updated: 2021/12/16

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Rosmanol Chemical Properties,Usage,Production

Anticancer Research

This is a polyphenol and an ester of caffeic acid and 3,4-dihydroxyphylllique acid.This is commonly found in Boraginaceae species and Nepettoideae, a Lamiaceaesubfamily. It plays an important role in anti-inflammatory, antitumor, andantiproliferation activities. It shows a dose-dependent inhibition of invasion,migration, and adhesion of LS-174-T human colon carcinoma cells. It inhibits thebone metastasis from breast cancer via NF-κB and its downward IL-8 pathway(Wang et al. 2012). It reduces ERK and COX-2 phosphorylation in colon carcinoma.It reduces the activity of DNA methyltransferase and interferes with RANKL/RANK/OPG networks in breast cancer cells. It targets NF-kB pathway in U938cells and PKA/CREB/MITF pathways in melanoma cells (Singh et al. 2016b). InU938 human leukemic cells, it sensitizes TNF-α-induced apoptosis by affectingNF-kB and ROS and inhibits the activation of NF-kB by inhibiting IκBαphosphorylation and degradation. It also reduces the levels of promoter activity ofCOX-2 protein induced by TPA in HT-29 colon cancer cells and antagonizes TPAstimulating effects on COX-2 expression (Petersen and Simmonds 2003).

Cytotoxicity

IC50 (μg/mL): 1.71 (A2780), 6.96(SW1573), 10.13 (WiDr), 10.13 (T-47D),1.46 (HBL-100) (Guerrero et al. 2006;Zhang et al. 2017)

Rosmanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Rosmanol manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Bacopa monnieri 2023-92-5
Price: US $0.00/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 1ton
Release date: 2023-02-09

Career Henan Chemical Co

Product: Rosmanol 80225-53-2
Price: US $8.00/KG
Min. Order: 1g
Purity: ＞98% HPLC
Supply Ability: kg--ton
Release date: 2020-02-20

80225-53-2, RosmanolRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate Glycine Citric acid Rosemary oil Rosmarinic acid Cryptotanshinone Rosemary Herb Extract Luteolin Salidroside Baicalin DL-Limonene SAGE OIL, SPANISH Caffeine Folic acid Ascoric Acid Rosemary Rosmanol phosphoric acid

[4aR-(4aa,9b,10a,10ab)]-1,3,4,9,10,10a-Hexahydro-5,6,9-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-2H-10,4a-(epoxymethano)phenanthren-12-one

(4aR,10aα)-1,3,4,9,10,10a-Hexahydro-5,6,9α-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-2H-10β,4aβ-(epoxymethano)phenanthren-12-one

20-Deoxocarnosol

6β,7α,11,12-Tetrahydroxyabieta-8,11,13-trien-20-oic acid 20,6-lactone

(4bR,8aS,9S,10S)-3,4,10-Trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one

(4bR,8aS,9R,10S)-3,4,10-trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one

Keywords honeysuckle extract

rat tail oxalic acid

2H-10,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6,9-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9S,10S,10aS)-

Rosmanol,Inhibitor,inhibit

Rosmano

rosemary antioxidant

Rosmanol-RM

80225-53-2

2023-92-5